Tos crónica persistente en adultos
Revisado por pares por Dr Philippa Vincent, MRCGPÚltima actualización por Dr Colin Tidy, MRCGPLast updated 24 Jul 2025
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En esta serie:TosResfriado comúnTos viralTos y resfriados en niñosExpectoración con sangreMedicamentos para la tos
A cough is termed "chronic" when it becomes persisting and long-term. This typically means it has hung around for more than eight weeks. Other types of cough such as a shorter-term cough, lasting up to three weeks, is called "acute", and if it is somewhere in the middle, it's called "subacute". Infections (such as the common cold or a chest infection) are the most common reason for acute coughs, but these usually settle within about three weeks.
See also the leaflet on Tos.
At a glance
A persistent cough can be caused by smoking, medicines, catarrh, acid reflux, asthma, or COPD.
Less common causes include tuberculosis, bronchiectasis, whooping cough, heart failure, and pulmonary fibrosis.
Sometimes no cause for a persistent cough is found.
See your GP if a cough does not settle after three weeks.
See your GP urgently if a persistent cough occurs with weight loss, chest pain, breathing problems, or sweats.
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What are the most common causes of a persistent cough?
There are many possible causes of a persistent cough but the following are the most common.
Fumar
Cigarette smoke is irritant to the lining of the airways, so being a smoker, or being around other people smoking (being a passive smoker) is a common cause of persistent cough. Smoking-related coughs are usually dry - in other words you don't cough anything up - and tend to be worst in the mornings.
Medicamentos
A group of medicines called angiotensin-converting enzyme (ACE) inhibitors may cause a persistent cough, but this occurs in fewer than 1 in 5 people taking these medicines. Examples of commonly used ACE inhibitors are lisinopril, ramipril, trandolapril y perindopril. If these medicines cause a cough, they can usually be replaced with other treatments. Some other medicines can also occasionally cause a cough. Cough caused by ACE inhibitors also tends to be a dry cough.
Catarrh coming from the back of your nose
Any condition which gives you more gunk in your nose, such as a common cold or a sore throat, may result in that gunk dripping down the back of your throat and making you cough. Examples of conditions which could do this are allergies, persistent rhinitis y pólipos nasales. This is called postnasal drip or upper airway cough syndrome. It tends to be worse in the morning and then improve during the day, and you usually cough up some mucus, which has originally come from your nose.
Reflujo ácido
Often if you have reflujo ácido, you are aware of it and get a burning sensation in your gullet, called heartburn. However, sometimes a cough is the only symptom of acid coming back (refluxing) up from your stomach. The stomach acid irritates the upper part of the airway around the voice box (larynx) and causes a cough. This kind of cough is sometimes worse after eating, or whilst you are eating. It may also be worse when you bend over, or while you are lying flat in bed.
Asma
Usually the cough of asma comes with other symptoms, such as shortness of breath when you exercise, or having wheezy breathing. However, asthma can start with just a cough. The cough tends to be worse during the night, or when you exercise.
Enfermedad pulmonar obstructiva crónica (EPOC)
The cough of EPOC usually comes with gradually worsening breathlessness when you do anything. Colds often progress to coughs which turn into chest infections and linger. It is usually caused by many years of smoking.
Can a persistent cough be a sign of cancer?
Volver al contenidoYou and your doctor will always want to rule out cancer if you have a cough which lingers. Cáncer de pulmón is more likely if you have been a smoker, but can occur in anyone. Signs that it might be cancer include losing weight and coughing up blood. You may also have pain in your chest or shoulder. Lung cancer is not one of the most common causes of persisting cough, but it is definitely one to check out.
Other types of cancer in the lungs can also cause cough, such as:
A spread of cancer from a cancer elsewhere (secondary tumours or metastases).
Lymphoma - a cancer of the bloodstream.
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What are the less common causes of a persistent cough?
Volver al contenidoOther possible causes of a persistent cough include:
Tuberculosis (TB). This is still very common in some parts of the world, although not seen very often in the UK.
Bronquiectasias. Usually if you have this condition, you bring up a lot of phlegm when you cough.
Having something (a "foreign body") stuck in the airways.
Whooping cough (pertussis). This cough tends to linger for a long time, although it has usually gone by eight weeks. There are characteristic bouts of coughing, followed by a "whoop" as you catch your breath.
Insuficiencia cardíaca. This means your heart isn't pumping as efficiently as it should do. Usually symptoms are being short of breath, tired and having swollen ankles. Occasionally there can be a cough.
Fibrosis pulmonar. This is caused by damage and scarring of lung tissue, which causes cough and breathlessness.
For more information on these conditions, follow the links where available.
Will the cause of a persistent cough always be found?
Volver al contenidoNo, not always. All the above conditions can be ruled out in some cases, but still leaving the cough behind. Sometimes you can be left with an unexplained cough. There are various names for this, including:
Idiopathic cough. (Idiopathic means there is no cause to be found.)
Chronic refractory cough.
Cough hypersensitivity syndrome.
Neurogenic or psychogenic cough.
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Cuándo ver a un médico por una tos persistente
Volver al contenidoIf you have had a cough which is not settling after three weeks then always see your doctor. Particularly see your doctor if you have a chronic cough along with:
Pérdida de peso.
Dolor en el pecho.
Problemas respiratorios.
Sudores.
¿Qué hará el doctor?
Volver al contenidoWhen you have a lingering cough and go to see a doctor, first they will want to ask you some questions (take a history). These might include:
Do you smoke?
Does anyone in your family have any chest-related conditions?
Have you ever had asma o fiebre del heno?
Do you get acidez?
Is your nose congested or runny?
Have you travelled abroad recently?
Questions about the cough: How long have you had it? When did it start? Did it start after a bacterial or viral infection? Do you bring up any phlegm or blood when you cough?
Do you have any other symptoms? (Such as weight loss, being short of breath, night sweats or pains in your chest or shoulder.)
What is/was your job?
¿Estás tomando algún medicamento?
The doctor will then want to examine you. What is checked may depend on your answers to the questions above. Examination might include:
Looking in your throat and nose.
Listening to your chest.
Feeling your neck and upper chest for lymph nodes.
Looking at your fingernail shape (this can indicate certain lung conditions).
Checking your temperature.
Feeling your tummy.
Checking your ankles for swelling.
The doctors may then do some further tests in the surgery, including:
Checking your oxygen levels. This is done with a pulse oximeter, which attaches to your finger and measures your pulse and oxygen levels.
Checking your peak flow. You will be asked to blow into a tube (a peak flow meter) to see how well your lungs work.
Espirometría. This is a more complex test of your lung function and you would be asked to come back to have this done in another appointment.
¿Necesitaré alguna prueba?
Volver al contenidoOther than the tests described above, you may need further tests for a persistent cough, depending on what has been found so far. You will almost certainly have a radiografía de tórax. If you produce any phlegm when you cough this will be sent off for analysis to see if it contains any germs, indicating infection. Some blood tests may be helpful.
If any of these tests show abnormalities in your lungs, you may be referred to a specialist for further investigations. These might include:
A bronchoscopy. A camera is passed with a tube into your airways, so that they can be seen and samples from the inside can be taken.
Other tests may be suggested if reflux or a nasal/sinus problem is suspected, and your cough doesn't clear up on treatment. For example, this might include an endoscopia. If a heart problem is suspected, further heart investigations such as an echocardiogram may be advised.
How to get rid of persistent cough
Volver al contenidoThis will depend on the cause. Smoking irritates the airways and is one of the biggest causes of cough. If it isn't causing the cough, it certainly won't be helping it. So if you smoke, you should consider quitting.
Other than that, the treatment will be specific to the cause. For example, inhalers may be prescribed for asthma, antacid medicines may be prescribed for reflux, nasal sprays may be prescribed for catarrh coming from the nose.
What is the best treatment for a persistent cough?
Volver al contenidoThe way to treat a persistent cough will entirely depend on the cause. It is important to try to work this out first, in order to get you on the right treatment. For example, if it turns out to be an infection, such as TB, you would be put on a special antibiotic regime. If it turns out to be asthma or COPD, you will be given inhalers, and these adjusted until the cough improves. If you have reflux, you might be given anti-reflux medicines such as proton pump inhibitors (PPIs). If you have congestion in your nose, you may be given a spray nasal de esteroides. Or you may be referred to an ear, nose and throat (ENT) specialist for further examination of the inside of your nose and sinuses. If you are on a medicine which has caused the cough, this can be stopped.
If you smoke, you will be advised strongly to dejar de fumar.
What will the treatment be if no cause is found?
Volver al contenidoNota: it is essential for the cause of the cough to diagnosed. Treating a cough without a diagnosis risks delaying specific treatment for a serious underlying cause, with the possibility of a worse outcome.
This is more difficult but there are a number of options which may be tried. These include:
Dejar de fumar and avoid passive smoking.
Soothing preparations. These don't cure the cough but may help to soothe it a little. Examples include simple linctus and cough sweets available from pharmacies.
Cough suppressing treatments. There are no magical treatments for suppressing cough but there are some which might be helpful, such as pholcodine or codeine.
Medicines which may make it easier to cough up the phlegm. These cough medicines are called mucolytics. These are only useful in people who have coughs which are not dry.
Steroid inhalers. These are usually used for people with asthma or COPD, but sometimes help reduce inflammation in the airways and improve a cough. They often help if your airways have persisting irritation after an infection which has settled.
Medicines which work to make the nerves less sensitive. These include amitriptyline, gabapentina y pregabalin.
Terapia del habla.
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Pecho y pulmones
Tos viral
Most coughs are caused by viral infections and usually soon go. This leaflet gives some tips on what to do and discusses which symptoms may indicate a more serious illness. Viral infections commonly affect the throat (larynx), the main airway (trachea), or the airways going into the lungs (bronchi). These infections are sometimes called laryngitis, tracheitis, or bronchitis. Cough is often the main symptom.
por la Dra. Surangi Mendis, MRCGP

Pecho y pulmones
Expectoración con sangre
Existen varias causas de expectorar sangre (hemoptisis). Si expulsas una gran cantidad de sangre, llama a una ambulancia de inmediato. Si expulsas cantidades menores de sangre, consulta a tu médico lo antes posible si no conoces la causa. Esto se debe a que, a veces, una condición grave como el cáncer de pulmón puede ser la causa. Como regla general, cuanto antes se diagnostique un problema grave, mejor será la probabilidad de que el tratamiento pueda mejorar el pronóstico. Este folleto explica las principales causas de expectorar sangre.
by Dr Hayley Willacy, FRCGP
Preguntas frecuentes
Can certain medications other than ACE inhibitors cause a persistent cough?
While ACE inhibitors are a known cause of persistent cough in fewer than 1 in 5 people, the article mentions that 'some other medicines can also occasionally cause a cough,' though it doesn't specify which ones.
What is postnasal drip, and how does it lead to a cough?
Postnasal drip, also known as upper airway cough syndrome, occurs when excess mucus, or 'gunk,' from your nose (perhaps due to a cold, allergies, persistent rhinitis, or nasal polyps) drips down the back of your throat. This irritation can make you cough, and you might cough up some of this mucus that originated in your nose. It often feels worse in the morning.
If I only have a cough, could it still be asthma?
Yes, it's possible. While asthma usually comes with additional symptoms like shortness of breath during exercise or wheezing, it can sometimes start with just a cough. This type of cough tends to be worse at night or when you exercise.
What are the common signs that a persistent cough might be linked to cancer?
If you have a persistent cough, especially if you have a history of smoking, a doctor will consider ruling out cancer. Key signs to look out for include unexplained weight loss, coughing up blood, or pain in your chest or shoulder.
Are there any specific symptoms that suggest my persistent cough could be heart failure?
Heart failure can occasionally cause a cough, but it's typically accompanied by other more common symptoms. These usually include being short of breath, feeling tired, and having swollen ankles. The cough is generally not the sole symptom.
What does a doctor typically ask about when investigating a persistent cough?
During your appointment, a doctor will likely ask about your smoking habits, any family history of chest conditions, if you've had asthma or hay fever, whether you get heartburn, if your nose is congested or runny, recent travel, and details about the cough itself (duration, onset, phlegm or blood). They'll also inquire about other symptoms such as weight loss, shortness of breath, night sweats, or pains, as well as your job and current medications.
If no cause for my persistent cough is found, what treatment options might be tried?
If the cause remains undiagnosed, several options may be explored. These include stopping smoking (and avoiding passive smoking), using soothing preparations like simple linctus or cough sweets, or cough suppressing treatments such as pholcodine or codeine. Medicines to help you cough up phlegm (mucolytics) might be used if you have a wet cough. Steroid inhalers, or medicines that make nerves less sensitive (like amitriptyline, gabapentin, or pregabalin), and even speech therapy are also possible treatments.
Lecturas adicionales y referencias
- Tos; NICE CKS, agosto 2023 (acceso solo en el Reino Unido)
- Michaudet C, Malaty J; Tos Crónica: Evaluación y Manejo. Am Fam Physician. 1 de noviembre de 2017;96(9):575-580.
- Visca D, Beghe B, Fabbri LM, et al; Manejo de la tos crónica refractaria en adultos. Eur J Intern Med. 2020 Nov;81:15-21. doi: 10.1016/j.ejim.2020.09.008. Epub 2020 Sep 19.
- Kruger K, Holzinger F, Trauth J, et al; Chronic Cough. Dtsch Arztebl Int. 2022 Feb 4;119(5):59-65. doi: 10.3238/arztebl.m2021.0396.
- Morice A, Dicpinigaitis P, McGarvey L, et al; Tos crónica: nuevas perspectivas y futuros prospectos. Eur Respir Rev. 30 de noviembre de 2021;30(162). pii: 30/162/210127. doi: 10.1183/16000617.0127-2021. Impreso el 31 de diciembre de 2021.
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About the authorView full bio

Dr Colin Tidy, MRCGP
Médico General, Autor Médico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
About the reviewerView full bio

Dra. Philippa Vincent, MRCGP
Médico General, Autor Médico
MB BS, Bsc, MRCGP (2000), DCH, DFSRH, DRCOG
Dra Philippa Vincent is an NHS GP working in North London.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Next review due: 23 Jul 2028
24 Jul 2025 | Última versión
11 May 2017 | Publicado originalmente
Escrito por:
Dr Colin Tidy, MRCGP

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