Demencia

What is dementia? ^{1 2}

Dementia is a syndrome caused by a number of brain disorders which cause memory loss, decline in some other aspect of cognition, and difficulties with activities of daily living.

The symptoms fall into three groups:

• Cognitive impairment: causing difficulties with memory, language, attention, thinking, orientation, calculation, and problem-solving.

• Psychiatric or behavioural disturbances: changes in personality, emotional control, and social behaviour; depression, agitation, hallucinations, and delusions.

• Difficulties with activities of daily living: driving, shopping, eating, and dressing.

Deterioration must represent a progressive decline from a previous higher level of functioning, and consciousness should not be clouded (compare with acute confusional state or delirium). Memory loss is typically for recent events and long-term memory can be remarkably intact.

Mild cognitive impairment (MCI) is a decline in cognitive function greater than expected, taking account of the subject's age and education, which is not interfering with activities of daily living.³ This is often clinically a pre-dementia state although there is great variability in progression rates of MCI to dementia. Studies report annual conversion rates from <5%-12-20% but 40-70% of patients with MCI may not progress to dementia for over a decade.³

How common is dementia? (Epidemiology)¹

• The total age-standardised population prevalence of dementia in people 65 years of age and older in the UK is 7.1%.

• Prevalence rises with age:
  

  • 0.9% for those aged 60-64 years.

  • 1.7% for those aged 65-69 years.

  • 3.0% for those aged 70-74 years.

  • 6.0% for those aged 75-79 years.

  • 11.1% for those aged 80-84 years.

  • 18.3% for those aged 85-89 years.

  • 29.9% for those aged 90-94 years.

  • 41.1% for those aged 95 years and over.

Although the age-specific dementia incidence appears to be declining, the number of people with dementia in England and Wales is likely to increase by 57% from 2016 to 2040. This increase is mainly driven by improved life expectancy.⁴

Causes of dementia (aetiology)^{1 5}

Some of the more common causes of dementia are:

• Alzheimer's disease (about 50%). Degeneration of the cerebral cortex, with cortical atrophy, neurofibrillary tangles, amyloid plaque formation and reduction in acetylcholine production from affected neurons.

• Vascular dementia (about 25%). Brain damage due to cerebrovascular disease: either major stroke, multiple smaller unrecognised strokes (multi-infarct) or chronic changes in smaller vessels (subcortical dementia).

• Dementia with Lewy bodies (DLB) (about 15%). Deposition of abnormal protein within neurons in the brain stem and neocortex.

• Frontotemporal dementia (less than 5%). Specific degeneration/atrophy of the frontal and temporal lobes of the brain. One type of frontotemporal dementia is Pick's disease, where protein tangles (Pick's bodies) are seen histologically.

• Demencia mixta.

• Enfermedad de Parkinson.

• Posterior cortical atrophy. Rare - considered a variant of Alzheimer's disease with earlier onset.⁶

• Potentially treatable dementias (fewer than 5%):
  

  • Abuso de sustancias.

  • Hipotiroidismo.

  • Space-occupying intracranial lesions.

  • Hidrocefalia normotensiva.

  • Sífilis.

  • Vitamin B12 deficiency.

  • Deficiencia de folato.

  • Pellagra.

• Genetic causes of dementia such as familial autosomal dominant Alzheimer's disease.

Symptoms of dementia (presentation)^{2 5}

There are subtle differences in the presentation of different types of dementia. These are covered in detail in their specific articles.

Alzheimer's disease tends to have an insidious onset, whereas vascular dementia typically has a series of stepwise increases in symptom severity. DLB may present with fluctuating levels of consciousness, hallucinations, sleep disorders, falls and Parkinsonian features.

In Parkinson's disease dementia, the Parkinsonian features predate the dementia by a significant amount of time. In frontotemporal dementia, behavioural changes (such as disinhibition or apathy) and language disturbances are often presenting features. It may be important to determine the type of dementia - in DLB, for example, making this diagnosis will have important implications for treatment (use of neuroleptics is avoided, as motor and mental impairment is worsened and mortality may be increased).⁷ Treatment guidelines vary slightly for some of the different types of dementia.

Dementia presents in contrast to acute confusional state, which is usually of recent onset and may have a reversible cause; the history should go back at least several months and usually several years.

For objective evidence, carry out a test of cognitive functioning (see 'Diagnosis', below).

Diagnosis of dementia^{1 7}

The diagnosis of dementia should only be made after:

• Comprehensive history and physical examination. The key to diagnosis is a good history of progressive impairment of memory and other cognitive functioning (usually requiring the help of a spouse, relative or friend).
  
  Make specific notes on the following:
  

  • Attention and concentration ability.

  • Orientation - time, place, person.

  • Memory - both short- and long-term.

  • Praxis - whether they can get dressed, lay a table, etc.

  • Language function (usually evident during questioning).

  • Executive function - problem-solving, etc.

  • Psychiatric features - depression, anxiety, psychotic symptoms.

• Medication review to exclude a cause which may be contributing to symptoms.

• A formal screen for cognitive impairment - see the separate Screening for Cognitive Impairment article. Tools include the Mini Mental State Examination (MMSE), the Six-item Cognitive Impairment Test (6CIT), the General Practitioner Assessment of Cognition (GPCOG) and the 7 Minute Screen (7MS).⁸

• Other reversible organic causes have been excluded.

NB: it is important to identify depression and treat it appropriately. Sometimes it is difficult to distinguish between depression and dementia and depression is quite common in dementia. If in doubt, treat.

Diagnostic criteria for all types of dementia

There are cognitive or behavioural symptoms which:¹

• Affect ability to function in normal activities.

• Represent a decline from a previous level of function.

• Cannot be explained by delirium or other major psychiatric disorder.

• Have been established by history-taking from patient and informant, and formal cognitive assessment.

• Involve impairment of at least two of the following domains:
  

  • Ability to acquire and remember new information.

  • Judgement, ability to reason or handle complex tasks.

  • Visuospatial ability.

  • Language functions.

  • Personality and behaviour.

Diagnosing dementia (Investigations)^{1 7}

• Ensure no treatable cause has been missed, by arranging FBC, ESR or CRP, MSU, U&E, LFT, glucose, Ca²⁺, TFT, B12 (serum cobalamin) and red cell folate.

  • The clinically normal level for cobalamin is unclear, although it is thought that serum cobalamin of less than 200 nanograms/L (148 picomol/L) is sensitive enough to diagnose 97% of people with vitamin B12 deficiency.⁹

  • Cobalamin levels are not easily correlated with clinical symptoms, although people with cobalamin levels of less than 100 nanograms/L (75 picomol/L) usually have clinical or metabolic evidence of vitamin B12 deficiency.

  • In the elderly, low serum cobalamin concentrations usually in the range 100–160 nanograms/L may occur in the absence of anaemia or macrocytosis, and clinically significant vitamin B12 deficiency may be present even with cobalamin levels in the normal range.

• VDRL/TPHA should not be performed routinely - only if risk factors are present.

• Consider blood cultures, CXR and MRI scan, and psychometric testing as appropriate to confirm diagnosis.

• Specialist assessment is required to determine the subtype of dementia. If this cannot be done on clinical grounds, perfusion hexamethylpropyleneamine oxime (HMPAO) single-photon emission computerised tomography (SPECT) may be used to distinguish between Alzheimer's disease, vascular dementia and frontotemporal dementia. This is not useful in the presence of Down's syndrome.

• CSF examination may occasionally be helpful if Creutzfeldt-Jakob disease or other forms of rapidly progressive dementia are suspected.

• Genetic clinical genotype analysis should only be requested where an inherited cause is suspected.

Management: general principles⁷

The 'Well pathway for dementia' document produced by NHS England summarises the content of the Implementation guide and resource pack for dementia care.¹⁰ This sets out what good-quality assessment, diagnosis, and care look like in relation to formal guidance. It also considers the views and expectations of people living with dementia and those of their carers. The guide has two clear requirements to enhance dementia care:

• Increasing the number of people diagnosed with dementia and beginning treatment within six weeks of referral.

• Improving post-diagnostic treatment and support quality for people with dementia and their carers.

Las personas con demencia se benefician de una atención centrada en la persona. Esto significa no solo respetar a la persona y a su cuidador, y tener en cuenta su perspectiva y sus interacciones, sino adaptar la gestión a ellos como individuos.

• Las personas con demencia no deben ser discriminadas a la hora de considerar opciones de tratamiento para otras enfermedades. Deben beneficiarse de un apoyo adecuado a sus necesidades y no deben ser discriminadas por motivos de raza, lengua, religión o sexualidad.

• Deben celebrarse conversaciones tempranas para permitir la planificación anticipada. Esto implica hablar sobre declaraciones o decisiones anticipadas, poderes notariales duraderos y planes sobre el lugar preferido de asistencia. Esta es una de las razones más importantes para el diagnóstico precoz y la derivación.

• A memory assessment service should act as the single point of referral for all patients with a suspected diagnosis of dementia. 50% of those diagnosed with mild cognitive impairment go on to develop dementia, according to National Institute for Health and Care Excellence (NICE) guidelines; so primary care professionals should consider referring at this stage.

• Valid consent should be sought for treatment, wherever possible. This may mean making information available to them in an appropriate form. The use by patients and carers of advocacy services and voluntary organisations should be encouraged. If patients are not competent to make a decision, the requirements of the Mental Capacity Act 2005 should be followed (see 'Mental capacity to make decisions',below).

• Los cuidadores deben recibir una evaluación de sus necesidades, tal como exigen la Ley de cuidadores y niños discapacitados de 2004 y la Ley de cuidadores (igualdad de oportunidades) de 2004. Debe ofrecerse a los cuidadores psicoeducación y terapia psicológica individual o de grupo, grupos de apoyo entre iguales, información en diversos medios y cursos de formación. También deben tenerse en cuenta cuestiones como el transporte, el cuidado nocturno y la atención de relevo. Véase el artículo independiente Apoyo a la familia de personas con demencia.

• Los gestores de la asistencia sanitaria y social deben adoptar un enfoque conjunto de la gestión, que incluya políticas y procedimientos escritos conjuntos y una planificación conjunta de los servicios que tenga en cuenta las opiniones de los usuarios y cuidadores locales. Los gestores y coordinadores de la asistencia deben garantizar que se revise periódicamente un plan de asistencia combinado, que tenga en cuenta las necesidades cambiantes del paciente y de los cuidadores, y que reciba la aprobación del paciente y de los cuidadores. Deberá asignarse personal sanitario y/o social específico para la aplicación del plan.

• Tras el diagnóstico, el paciente y sus cuidadores deben recibir información escrita sobre:
  

  • Los síntomas y signos de la demencia.

  • Evolución y pronóstico.

  • Tratamientos.

  • Servicios locales de asistencia y apoyo.

  • Grupos de apoyo.

  • Fuentes de asesoramiento financiero y jurídico, y defensa.

  • Cuestiones médico-legales, incluida la conducción.

  • Fuentes de información locales, como bibliotecas y organizaciones de voluntariado.

• El personal sanitario y de asistencia social debe tratar de fomentar la independencia en la medida de lo posible, incluida la movilidad. Deben fomentarse las estrategias para hacer frente a las discapacidades, como las modificaciones del entorno vital y la simplificación de las actividades cotidianas.

• Los jóvenes con demencia y las personas con dificultades de aprendizaje tienen necesidades especiales y requieren asesoramiento especializado y apoyo específico.

NICE Quality Statements

NICE has produced Quality Standards for dementia, and supporting people to live well with dementia. ¹¹ These link into the NICE pathway on dementia, and provide a number of quality statements, advising on principles of care and good standards of care.

Mental capacity to make decisions

If the patient does not have capacity to make decisions, National Institute for Health and Care Excellence (NICE) and General Medical Council (GMC) guidance should all be followed.^{12 13} The Mental Capacity Act 2005 has the following principles:¹⁴

• Adults must be assumed to have capacity to make decisions about their care unless proved otherwise.

• Individuals should be given all available support to help them come to a decision.

• Individuals should retain the right to make what others might consider eccentric or unwise decisions.

• Anything done on behalf of an individual without capacity must be in that person's best interests.

• The rights and basic freedoms of an individual without capacity should be restricted as little as possible.

• With the patient's consent, relatives and carers should be involved in management decisions. Relatives and carers should also have their own needs assessed.

Conducir

People who have been diagnosed with dementia are legally obliged to inform the Driver and Vehicle Licensing Agency (DVLA).¹⁵ For HGV or passenger-carrying vehicles, a licence would be revoked at this point, but some people may be able to continue driving an ordinary car, subject to medical reports or assessment, and annual review.

Management: non-pharmacological⁷

Non-pharmacological interventions should be tailored to the individual person's preferences and abilities as well as to local resources, and adapted depending on response. These include:

• Cognitive stimulation programmes.

• Multisensory stimulation.

• Music therapy.

• Art therapy.

• Bailando.

• Masaje.

• Aromaterapia.

• Structured exercise programmes.

• Terapia asistida con animales.

Community and hospital care

Patients should be cared for in the community as much as possible. However, if they become severely disturbed and need to be contained for their own safety or the safety of others, inpatient care should be considered (this might include those liable to be detained under the Mental Health Act 1983). Inpatient admission would also be justified for patients with complex physical and psychiatric problems who could not be properly assessed in the community.

Non-pharmacological management of behaviour that challenges⁷

People with dementia who develop non-cognitive symptoms that cause them significant distress, or who develop behaviour that challenges, should have an assessment at an early opportunity to establish generating and aggravating factors. Interventions to improve such behaviour or distress should be recorded in their care plan. Factors which may exacerbate violent or aggressive behaviour, or increase the risk of harm to self or others include:

• Hacinamiento.

• Lack of privacy.

• Boredom or lack of activity.

• Poor communication.

• Conflict.

• Weak clinical leadership in care home settings.

Staff should identify, monitor and address factors such as these, and be trained in managing aggression or agitation.

Management: pharmacological treatment of dementia⁷

Acetylcholinesterase (AChE) inhibitors

NICE has reviewed its guidance on the use of these drugs (donepezil, galantamine or rivastigmine) in mild and moderate Alzheimer's disease, and updated the 2006 dementia guidance in the relevant sections to incorporate it.¹⁶

• AChE inhibitor treatment (donepezil, galantamine or rivastigmine) should be considered in patients with mild or moderate Alzheimer's disease. It should only be started by dementia specialists (psychiatrists, neurologists, and physicians specialising in the care of older people), after appropriate discussion with family and carers. These drugs have cholinergic side-effects and should be started at a low dose, and then be titrated according to response.

• The drug with the lowest cost should be used as first choice. They should not be prescribed for mild cognitive impairment.

• It should be continued for only as long as it is having a worthwhile effect on cognitive, global, functional or behavioural symptoms.

• Patients on treatment should be reviewed regularly by an appropriate specialist team, or by shared care with GPs where such an agreement exists. This should include cognitive, global, functional and behavioural assessments and discussion with carers.

• The MMSE should be part of a full assessment of a patient, including quality of life changes and social interaction. Clinicians should be free to treat patients after this assessment, and should not be precluded from doing so on the basis of the MMSE score. The MMSE is not sensitive enough to differentiate between patients who would benefit from treatment and those who would not, and was not designed for this use.

• Evidence from clinical studies and Cochrane reviews suggests that there is benefit from AChE inhibitors in mild-to-moderate Alzheimer's disease and in vascular cognitive impairment, but that the benefits are small.^{17 18} There is evidence that continuing use in moderate-to-severe disease confers some benefit.¹⁹

• AChE inhibitors can be used in dementia with Lewy bodies and mixed dementia (vascular/Alzheimer's/Parkinson's) but should not be used for frontotemporal dementia or cognitive impairment associated with multiple sclerosis according to NICE guidelines.⁷

N-methyl-D-aspartate (NMDA) antagonists²⁰

Memantine (an NMDA antagonist) is recommended by NICE as a second-line option for managing patients with moderate Alzheimer's disease where AChE inhibitors are not tolerated or are contra-indicated, or in the treatment of severe Alzheimer's disease.⁷ Memantine can be used in addition to an AChE inhibitor for moderate or severe dementia.

Pharmacological treatment of associated non-cognitive problems

• Where antidepressants are needed, avoid tricyclic antidepressants and other anticholinergics, as they may have an adverse effect on cognition.

• Antipsychotics should be avoided where possible in Alzheimer's disease, vascular dementia or mixed dementias. Where needed for psychotic features or agitation:
  

  • Discutir los riesgos (sedación, riesgo de ictus, empeoramiento de la cognición) y considerar otros factores de riesgo cerebrovascular.

  • Lo ideal es tratarlo bajo consejo de un especialista.

  • Controlar los efectos con regularidad.

  • Utilice la dosis más baja posible y auméntela lentamente cuando sea necesario.

  • Treatment should be time-limited.

  • Consider risperidone as first choice.¹

• In those with Parkinson's dementia or DLB, antipsychotics are more likely to cause severe sensitivity reactions, and should be avoided where possible.

• Occasionally aggression, violence or agitation pose a threat to safety, and where non-pharmacological measures have failed, benzodiazepines or antipsychotics may be required urgently.
  

  • La medicación oral debe utilizarse siempre que sea posible; la vía intramuscular (IM) es más segura que la intravenosa (IV) cuando no es posible.

  • El lorazepam, el haloperidol o la olanzapina deben utilizarse cuando se requiera la administración IM. No se recomienda la administración IM de diazepam y clorpromazina.

  • Los efectos deben vigilarse estrechamente.

Gestión: cuidados paliativos y al final de la vida

Physical, psychological, social and spiritual support should be offered, and dementia patients should have the same access to palliative care services as any other patient. Oral nutrition should be encouraged for as long as possible. Percutaneous endoscopic gastrostomy (PEG) feeding may be appropriate in patients with transient dysphagia but is not recommended in patients with severe dementia, as there is no evidence of increased survival or reduced complications.^{21 22} Decisions to withhold nutritional support should be taken within a legal and ethical framework. Fever may be managed with antipyretics and mechanical cooling. Palliative antibiotics should be given after an individual assessment of the patient. Resuscitation is unlikely to succeed in patients with severe dementia. If no advanced decision has been taken by the patient, the decision to resuscitate should take into account the views of the carers and the multidisciplinary team, the Resuscitation Council UK 's guidance, and the Mental Capacity Act 2005.²³ The decisions should be recorded in the notes and care plan.

Detección y prevención

Patients and relatives with a suspected genetic cause for dementia should be offered genetic counselling by the regional genetic services.

The focus for prevention should be the modification of behaviour in middle-aged and older people (reducing smoking, alcohol consumption, and obesity, and treating other cerebrovascular disease risk factors such as hypertension and hypercholesterolaemia).⁷

Pronóstico

Dementia usually continues to worsen over time. Average life expectancy for a person age 65 years or older diagnosed with most dementia types is about 4 to 8 years but some individuals with Alzheimer's disease may live up to 20 years after the first signs of disease.⁵ The most common cause of death in Alzheimer's disease is pneumonia.