vacuna contra el VPH
Human papillomavirus immunisation
Revisado por pares por Dr Krishna Vakharia, MRCGPÚltima actualización por Dr Colin Tidy, MRCGPLast updated 19 de mayo de 2023
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Human papillomavirus (HPV) is a tiny germ that almost everyone gets at some point in their life. Usually it is fairly harmless, but infection with some types of HPV can cause cancer of the neck of the womb (cervix), anus and penis. These cancers take many years to develop after the infection with HPV. Genital warts are also caused by HPV.
The HPV vaccine should dramatically reduce cervical, anal and penis cancer cases in the future and lead to fewer cases of genital warts. It may also reduce other cancers thought to be sometimes due to HPV.
HPV vaccines were introduced in the UK for girls in 2008 and for boys in 2018. Men who have sex with men (MSM) can also access the HPV vaccine until the age of 45. Women are still advised to attend for cervical screening tests, even if they have been immunised against HPV.
At a glance
The HPV vaccine prevents HPV infection, which can cause certain cancers and genital warts.
It is offered to both boys and girls, and to MSM, as part of the NHS vaccination programme.
Most people need two doses of the vaccine, but some may require three.
The vaccine significantly reduces the risk of cervical cancer and other HPV-related cancers.
Regular cervical screening is still important, even after vaccination.
Side effects are usually mild, such as soreness at the injection site.
Condoms do not fully protect against HPV infection.
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What is the HPV vaccine?
The HPV vaccine prevents you from getting HPV. It is now offered to both boys and girls, and to MSM, as part of the NHS vaccination programme.
The HPV vaccine used for the NHS HPV immunisation programme is called Gardasil® or GARDASIL® 9 and you only need two injections of it (three if you have your first dose over the age of 15). It is really effective, stopping 99% of HPV infections.
There are many different strains or types of HPV. Two - 16 and 18 - are responsible for about 70% of cervical cancers. Two others - 6 and 11 - account for over 90% of cases of genital warts. GARDASIL® 9 protects against HPV infection with the same four HPV types (6, 11, 16, 18) as Gardasil®. However, it also protects against five additional HPV types (31, 33, 45, 52, 58).
During the 2021-22 school year, the vaccine given will change from Gardasil® to GARDASIL® 9.
How effective is the HPV vaccine?
Volver al contenidoA 2021 study looked at rates of cervical cancer before and since the introduction of the HPV immunisation programme. It showed that among women vaccinated at the age of 12-13, rates of cervical cancer were reduced almost tenfold, with 87% lower rates.
Among women vaccinated at age 16-18, rates were 34% lower compared to women who had not been vaccinated.
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How many doses are there in the HPV vaccine?
Volver al contenidoThe HPV vaccine works in two doses for most people, though in some circumstances three may be required.
The first dose is in year 8 at school (school year 9 in Northern Ireland and S1 in Scotland), at age 12-13.
The second is done between 6 and 24 months later.
If you miss the first dose at age 12, you can get it at any age until 25, or until 45 for MSM.
If you are over 15 when you have the first dose, or have a weakened immune system, you will need three doses instead of two. You have one, then a second one a month later, and a third five months after that.
At what age do I get the HPV vaccine?
Volver al contenidoThrough the school vaccination programme, the first dose is given at age 12-13 and the second dose 6-12 months later.
If you miss this vaccination, you can access the vaccine through your school or through your GP up to the age of 25 years.
MSM can have the vaccine through an NHS sexual health or HIV clinic at any time up to 45 years of age.
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What are the side-effects of the HPV vaccine?
Volver al contenidoLike any injection, it is a bit painful and will be sore at the injection site for a few days.
Very rarely, some people may have an allergic reaction (anafilaxia) to the HPV vaccine, which the healthcare professional administering the vaccine will be fully trained to deal with.
In the overwhelming majority of cases, there are barely any serious side-effects.
Does the HPV vaccine offer benefits if you're already sexually active?
Volver al contenidoIt's still worth getting it done if you are under the age of 25, as long as you were invited through the NHS but missed your vaccine.
Do condoms prevent you from catching HPV?
Volver al contenidoCondoms are generally a really good idea, because they prevent you catching sexually transmitted infections like clamidia y el VIH.
Condoms don't prevent you catching HPV though, because you can catch HPV from close sexual contact without necessarily having sexual activity.
Do lesbian women still need the HPV vaccine?
Volver al contenidoYes! The HPV infection has been found in women who have sex with women: they still benefit from the vaccination.
Do gay men still need the HPV vaccine?
Volver al contenidoAbsolutely. Men who have sex with men (MSM) are at higher risk of anal cancer, and the number of men being diagnosed with anal cancer is increasing.
I thought the HPV vaccine was three doses, not two?
Volver al contenidoScientists realised that two doses were just as good as three. So from September 2014 they started giving people just two injections. That's why you might know older girls who had three doses, but you're only getting two.
Is it just the UK that gives the HPV vaccine?
Volver al contenidoNo. It's also given routinely to boys and girls in the USA, Australia, Canada and most of Europe. In fact, around 80 million people get vaccinated every year.
If I've had the HPV vaccine can I still get cervical cancer?
Volver al contenidoThe chances of you getting cervical cancer are much lower, but you can still get it: 30% of cervical cancers aren't related to the types of HPV you'll be vaccinated against.
You should still have cervical smears, which check for the warning signs of cervical cancer.
If I've had the HPV vaccine can I still get anal cancer?
Volver al contenidoAs with cervical cancer, HPV vaccination will greatly reduce your risk of getting anal cancer. However, it doesn't offer complete protection, so you should still be aware of the symptoms and get them checked out if you do develop them.
Can HPV cause cancer?
Volver al contenidoScientists began to realise that people with some types of cancer were more likely to have an HPV infection. They noticed this particularly with cáncer de cuello uterino, vulval cancer, anal cancer, oropharyngeal cancer y penile cancer.
Eventually scientists made the link: in some people, HPV isn't harmless ... it can cause cancer.
Does everyone infected with human papillomavirus get cancer?
Thankfully not. Only about 1 in 500 people infected with HPV go on to get cancer. But because we're talking about millions of people with HPV, it leads to thousands of cancers.
Why is there so much attention on cervical cancer?
Cervical cancer is the most common of the cancers that are caused by HPV. The others are all quite rare. But cervical cancer is the most common cancer in women aged under 35: there are about 3,000 new cases per year in the UK and sadly about 900 women die from it too (often older women who haven't benefited from the vaccine).
It is estimated that HPV causes 70% of cervical cancer, so if we can prevent young women getting HPV in the first place it should reduce their chances of getting cervical cancer.
How does HPV affect men?
Volver al contenidoIn men, HPV infection can lead to anal cancer, oropharyngeal cancer and penile cancer. Although these cancers aren't as common as cervical cancer, they still affect hundreds of men a year in the UK. Preventing men from getting HPV should dramatically reduce the risk of these cancers.
The risk of HPV-related cancer is higher among men who have sex with men (MSM). For this reason, along with a national HPV vaccination programme for 12- to 13-year-olds, there is another national programme for MSM.
You can access HPV immunisation, if you have not been immunised:
From sexual health or HIV clinics.
If you are aged 45 or under.
If you are MSM (assigned male at birth); or
If you are a trans man (assigned female at birth).
Trans women (women who were assigned male at birth) are also eligible for HPV immunisation on the NHS if their risk of catching HPV is similar to the risk of MSM who are eligible for the vaccine.
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Preguntas frecuentes
What is HPV and why is there a vaccine for it?
HPV stands for Human Papillomavirus. It's a common virus that, in some people, can lead to serious health issues like certain types of cancer. The vaccine prevents infection from the HPV types most commonly linked to these cancers and other conditions like genital warts.
What specifically does GARDASIL® 9 protect against?
GARDASIL® 9 protects against nine types of HPV. These include types 6, 11, 16, and 18, which were covered by the previous Gardasil® vaccine and are responsible for most cases of genital warts and a large percentage of cervical cancers. Additionally, GARDASIL® 9 offers protection against HPV types 31, 33, 45, 52, and 58.
Why is the HPV vaccine now offered to both boys and girls?
The HPV vaccine is offered to both boys and girls because HPV can cause cancers in both sexes, including anal cancer, oropharyngeal cancer, and penile cancer in men. Vaccinating boys helps protect them from these cancers and also contributes to reducing the overall spread of the virus in the population.
Who can get the HPV vaccine and up to what age if they missed it in school?
If you missed the HPV vaccine in school, you can usually still get it. Through your school or GP, you can access the vaccine up to the age of 25. Men who have sex with men (MSM) can access the vaccine through an NHS sexual health or HIV clinic up to the age of 45.
What types of cancer are linked to HPV, besides cervical cancer?
Beyond cervical cancer, HPV infection has been linked to several other cancers. These include vulval cancer, anal cancer, oropharyngeal cancer (which affects the throat), and penile cancer. While cervical cancer is the most common HPV-related cancer, these other types also affect hundreds of people annually.
Does having the HPV vaccine mean I don't need to worry about cervical or anal cancer screenings?
No, even if you've had the HPV vaccine, you should still attend regular screenings like cervical smears. While the vaccine significantly reduces your risk of cervical and anal cancers, it doesn't offer complete protection, as some cancer-causing HPV types are not covered by the vaccine. Screenings help detect any warning signs early.
Why do some people need two doses of the HPV vaccine and others three?
Most people only need two doses of the HPV vaccine. Scientific research showed that two doses were as effective as three for the majority. However, if you are over 15 years old when you receive your first dose, or if you have a weakened immune system, you will need three doses to ensure full protection.
Lecturas adicionales y referencias
- Cervical cancer - UK mortality statistics; Investigación del Cáncer Reino Unido
- Calendario completo de vacunación rutinaria del NHS; GOV.UK
- HPV vaccination guide (easy to read leaflet as PDF on HPV vaccination); Salud Pública de Inglaterra
- Declaración del Comité Conjunto de Vacunación e Inmunización (JCVI) sobre la vacunación contra el VPH en niños 2018
- Declaración provisional del Comité Conjunto de Vacunación e Inmunización (JCVI) sobre la extensión de la vacunación contra el VPH a los adolescentes varones 2017
- Cambios en la vacuna del programa de inmunización contra el VPH: Carta; Director de Comisionamiento y Operaciones de Salud Pública de NHS England y NHS Improvement y Jefe de Inmunización de Public Health England; GOV.UK, julio de 2021
- Falcaro M et al. Los efectos del programa nacional de vacunación contra el VPH en Inglaterra, Reino Unido, sobre el cáncer cervical y la incidencia de neoplasia intraepitelial cervical de grado 3: un estudio observacional basado en registros. Lancet 2021 Nov; https://doi.org/10.1016/S0140-6736(21)02178-4
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About the authorView full bio

Dr Colin Tidy, MRCGP
Médico General, Autor Médico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
About the reviewerView full bio

Dr Krishna Vakharia, MRCGP
Chief Medical Officer for Health, Optum UK
MBChB, MRCGP(2013), BMedSci (hons), DFSRH, DRCOG, PGDipDerm (Distn)
La Dra. Krishna Vakharia es una médica general del NHS. También es examinadora habitual del Diploma de Posgrado en Dermatología Práctica en la Universidad de Cardiff, además de ser la Directora Médica de salud en Optum UK.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 12 de mayo de 2028
19 de mayo de 2023 | Última versión

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