Diamorphine for pain relief
Revisado por pares por Dr Colin Tidy, MRCGPÚltima actualización por Michael Stewart, MRPharmSLast updated 19 Ene 2023
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Diamorphine is prescribed to treat severe pain.
It will usually be given to you by a doctor or nurse as an injection. A nasal spray may sometimes be used for children in hospital.
The most common side effects of diamorphine are constipation, drowsiness, and feeling sick (nausea).
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About diamorphine
Tipo de medicamento | Analgésico opioide fuerte |
Usado para | Severe pain |
También llamado | Diacetylmorphine (in US) |
Disponible como | Injection, tablets and nasal spray |
What is diamorphine used for?
Volver al contenidoDiamorphine is a analgésico opioide fuerte used in particular to treat pain after a surgical operation and pain caused by cáncer.
It may also be used following a ataque al corazón, or for breathlessness caused by fluid in the lungs. It works on your nervous system and brain to reduce the amount of pain you feel.
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What is diamorphine available as?
Volver al contenidoDiamorphine is available as:
An injection.
Nasal spray.
Tablets.
Diamorphine is usually given by injection. Tablets are rarely prescribed because other strong opioids, such as morfina, are absorbed better when taken by mouth.
For children with severe pain, diamorphine may be given as a nasal spray in hospital emergencies. This is quicker and less distressing than an injection.
Side effects of diamorphine
Volver al contenidoCommon side effects of diamorphine are:
Feeling drowsy or sleepy.
Sentirse mareado.
Náuseas.
Estar enfermo (vómitos).
Estreñimiento.
Boca seca.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
Los efectos no deseados a menudo mejoran a medida que su cuerpo se adapta al nuevo medicamento, pero hable con su médico o farmacéutico si algún efecto secundario persiste o se vuelve problemático.
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How to manage diamorphine side effects
Volver al contenidoCommon diamorphine side effects | ¿Qué puedo hacer si experimento esto? |
Feeling dizzy, sleepy or drowsy, blurred vision | Do not drive and do not use tools or machines. Do not drink alcohol |
Sentirse enfermo o estar enfermo | Stick to simple meals - avoid rich or spicy foods. Your doctor may prescribe a medicine to ease the sickness |
Estreñimiento | Consume una dieta equilibrada y bebe mucha agua cada día. Si esto sigue siendo un problema, habla con tu médico |
Boca seca | Take frequent sips of water. Try chewing sugar-free gum or sucking sugar-free sweets |
Other side effects of diamorphine include: sweating, feeling confused, difficulties passing urine, flushing, the sensation of having a 'thumping heart' (palpitations), mood changes, reduced appetite, rash, and itching | Si alguno de estos se vuelve problemático, hable con su médico |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
Importante: if you are caring for someone who has recently been given a dose of diamorphine and you notice the following side effects, alert a doctor or nurse as soon as possible:
Very small, 'pinpoint' pupils (the black circle of the eye).
Shallow breathing or difficulty breathing.
Losing consciousness (falling asleep).
Having a fit (seizures or convulsions).
Who should not have diamorphine?
Volver al contenidoSome medicines are not suitable for people with certain conditions. Before taking diamorphine it is important that your doctor knows:
Si estás embarazada, intentando concebir o amamantando.
If you have heart, liver, or kidney problems.
Si tienes problemas de próstata o alguna dificultad para orinar.
If you have any breathing problems, such as asthma or enfermedad pulmonar obstructiva crónica (EPOC).
If you have been told you have baja presión arterial (hipotensión).
Si tienes algún problema con tu tiroides o glándulas suprarrenales.
If you have epilepsia.
Si tienes un problema con tu conducto biliar.
If you have severe diarrhoea, or have been constipated for more than a week, or have an inflammatory bowel problem.
If you have a condition causing muscle weakness, called miastenia gravis.
Si recientemente has tenido una lesión grave en la cabeza.
If you have ever had a mental health problem called psicosis.
Si alguna vez has sido dependiente de las drogas o el alcohol.
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
How diamorphine is given
Volver al contenidoDiamorphine is usually given as an injection into a muscle or directly into a vein. A doctor or nurse will give the injection, and it may be repeated every four hours to control pain.
Diamorphine can also be given as an injection just under the skin, often using a syringe driver.
A syringe driver is a small device that delivers controlled doses through a needle that stays in place. This allows pain relief to be given when needed, without repeated injections. The device limits how much diamorphine can be given over 24 hours.
In hospital, children with severe pain may be given diamorphine as a nasal spray. This provides fast pain relief and is often used in emergencies. The dose depends on the child’s weight.
Obteniendo el máximo de tu tratamiento
Volver al contenidoRead the patient information leaflet that comes with the medicine. It explains how diamorphine works and lists possible side effects.
Ask your doctor about alcohol. You may be advised not to drink alcohol while taking diamorphine, as it can increase side effects such as dizziness and drowsiness.
Driving may be affected. Diamorphine can slow your reactions and make driving unsafe. It is illegal to drive if your ability is impaired. If you do drive, carry proof that the medicine has been prescribed for you.
If you are travelling abroad and need to take diamorphine with you, carry a letter from your doctor. Diamorphine is a controlled drug and is subject to legal restrictions in many countries.
Check other medicines first. Some over-the-counter medicines can increase side effects when taken with diamorphine. Ask a pharmacist before taking any new medicine.
Tell healthcare professionals that you are taking diamorphine before having any other treatment.
Diamorphine is used for short periods only. Long-term use can lead to dependence and withdrawal symptoms such as restlessness or irritability. Speak to your doctor or pharmacist if you are concerned.
How to store diamorphine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.
Preguntas frecuentes
Volver al contenidoHow long does it take for diamorphine to work?
Diamorphine usually starts to work in 15-20 minutes when injected into a muscle, such as your thigh or bottom, and lasts for 2-4 hours.
Is it safe to have diamorphine during pregnancy?
Diamorphine is usually only used early in pregnancy. Using it for a long time can cause the baby to become dependent and have withdrawal symptoms after birth. If taken close to delivery, it can also affect the baby’s breathing
What's the difference between diamorphine and morphine?
Diamorphine is a stronger and faster-acting form of morphine. Once in the body, diamorphine is converted into morphine, but it reaches the brain more quickly, providing faster pain relief.
Is diamorphine addictive?
Yes, diamorphine can be addictive, especially with regular or long-term use. It can cause dependence, meaning you may experience withdrawal symptoms if it is stopped suddenly.

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Lecturas adicionales y referencias
- Manufacturer's PIL, Diamorphine Hydrochloride BP for Injection 5 mg, 10 mg, 30 mg, 100 mg, 250 mg and 500 mg; Wockhardt UK Ltd, The electronic Medicines Compendium. Dated April 2020.
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About the author

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
Médico General, Autor Médico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 18 Jul 2027
19 Ene 2023 | Última versión

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