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Paracetamol and metoclopramide for migraine

Paramax

Clinical author's note Michael Stewart 08/08/2023: Paramax® tablets and sachets were discontinued in the UK in 2020. At the time of review there are no branded or generic products containing the combination of paracetamol with metoclopramide available in the UK. This combination may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.

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About paracetamol and metoclopramide

Tipo de medicamento

An analgesic with an anti-emetic

Utilizado para

The treatment of migraine attacks

También llamado

Paramax® (discontinued)

Disponible como

Tablets and sachets

Paramax® is a combination medicine containing paracetamol and metoclopramide. Paracetamol belongs to a group of medicines known as analgesics (painkillers). It helps to ease the pain you feel during a migraine headache. Metoclopramide is an anti-sickness medicine, also called an anti-emetic. It helps to stop you from feeling sick. It does this in part by moving the food in your stomach through your digestive system more quickly.

Before taking paracetamol and metoclopramide

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking the tablets/sachets it is important that your doctor knows:

  • If you are under 18 years old, or over 65 years old. This is because metoclopramide can cause problems in people of these ages.

  • If you are pregnant or breastfeeding. Although paracetamol and metoclopramide are not known to be harmful to an unborn baby, you should tell your doctor if you think you could be pregnant.

  • If you have any allergies, or have asthma.

  • If you have been told you have an irregular heart rhythm.

  • Si sabe que tiene algún problema en el aparato digestivo, como una obstrucción o alguna hemorragia interna.

  • If you have any problems with your liver or kidneys, or if you regularly drink large amounts of alcohol.

  • If you have epilepsy, or have Parkinson's disease.

  • If you have a tumour on your adrenal gland, known as phaeochromocytoma.

  • Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.

  • Si alguna vez ha tenido una reacción alérgica a un medicamento.

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How to take paracetamol and metoclopramide

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about paracetamol and metoclopramide and it will provide you with a full list of the side-effects which you may experience.

  • Take Paramax® exactly as your doctor tells you to. It is usual to take two tablets or two sachets at the start of an attack, and then to take two further tablets or sachets every four hours if needed. You must not take more than a total of six tablets or six sachets in any 24-hour period.

  • The tablets can be taken with a drink of water. If you have been supplied with sachets, dissolve the powder from two sachets into quarter of a glassful of water before taking.


Aproveche al máximo su tratamiento

  • Hay varias cosas que pueden desencadenar migrañas en algunas personas. Por ejemplo, algunos alimentos (como el queso, el chocolate y el vino tinto), las preocupaciones, la luz solar intensa, dormir demasiado o demasiado poco y saltarse comidas. Si no estás seguro de si estas cosas te desencadenan una migraña, puede ayudarte llevar un diario de migrañas. Anota cuándo y dónde empezó cada crisis de migraña, qué estabas haciendo y qué habías comido ese día. Es posible que aparezca un patrón y que puedas evitar algunas de las cosas que desencadenan un ataque.

  • Try to keep your follow-up appointments with your doctor. Paramax® will only be prescribed for short-term use - it must not be taken for more than five consecutive days, and a course of treatment will last no longer than three months in total. If you find that the tablets/sachets do not relieve your migraine, discuss this with your doctor as an alternative preparation may prove to be more effective for you.

  • It is important that you do not take more than one preparation containing paracetamol at a time. Paracetamol is an ingredient in a number of over-the-counter preparations, including many cold and flu products. Paracetamol may also be contained in painkillers which you may already have been prescribed by your doctor. Before taking any other medicines, check the label to see whether they contain paracetamol.

  • This medicine is used to treat headache pain during a migraine attack, but there are other medicines available that may help to reduce the number of migraine attacks. If you have migraines frequently, discuss this with your doctor.

  • Some people who get frequent migraine attacks are in fact getting medication-induced headache. Medication-induced headache (also called medication-overuse headache) is caused by taking painkillers too often. If you use painkillers on more than two days a week on a regular basis, you may be at risk of this. You should talk to your doctor if you suspect it.

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Can paracetamol and metoclopramide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with Paramax®. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Paramax® side-effects

¿Qué puedo hacer si me ocurre esto?

Sensación de mareo o sueño

Si esto ocurre, no conduzca ni utilice herramientas o máquinas.

Diarrea

Beber mucha agua para reponer los líquidos perdidos

Breast changes, irregular periods, mood changes

Si alguno de ellos le resulta molesto, hable con su médico

Trastornos musculares o del movimiento angustiosos que afectan al cuerpo, la cara o los ojos.

Informe a su médico

directamente

Si experimenta cualquier otro síntoma que crea que puede deberse al medicamento, hable con su médico o farmacéutico.

How to store paracetamol and metoclopramide

  • Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.

Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.

Si va a someterse a una operación o a un tratamiento dental, comunique a la persona que lleve a cabo el tratamiento qué medicamentos está tomando.

No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.

Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.

Informar de los efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.

Lecturas complementarias y referencias

Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • Fecha de la próxima revisión: 29 de agosto de 2026
  • 30 ago 2023 | Última versión

    Última actualización

    Michael Stewart, MRPharmS

    Revisado por expertos

    Sid Dajani
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