Duloxetine for mood and nerve disorders
Cymbalta, Depalta, Duciltia
Revisado por pares por Dr Colin Tidy, MRCGPÚltima actualización por Michael Stewart, MRPharmSLast updated 17 Ago 2024
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Duloxetine (Cymbalta®, Depalta® and Duciltia®) is prescribed to treat mood and nerve disorders. You may also be prescribed generic duloxetine capsules.
30 mg and 60 mg dosages are usually given for the treatment of depression, anxiety, and nerve pain.
Each time you collect a prescription from the pharmacy make sure the strength of your medicine (30 mg or 60 mg) is the same as before. Ask your pharmacist if you have any questions or concerns.
Common side effects of duloxetine include feeling sick (nausea), dry mouth, headache, constipation, and diarrhoea. Duloxetine can also make you feel dizzy or sleepy. If this happens, do not drive and do not use tools or machines.
Please tell your doctor if you feel that you are getting worse, or if you experience any troublesome side effects.
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About duloxetine
Tipo de medicamento | A serotonin and noradrenaline reuptake inhibitor |
Usado para | Depression; anxiety disorder; pain caused by nerve damage in people with diabetes |
También llamado | Cymbalta®; Depalta®; Duciltia® |
Disponible como | Cápsulas |
What is duloxetine used for?
Volver al contenidoDuloxetine is a type of antidepressant called a serotonin and noradrenaline reuptake inhibitor (SNRI). It is used to treat depresión, trastornos de ansiedad, and pain caused by nerve damage in people with diabetes, called neuropatía diabética.
Duloxetine is thought to work by regulating the levels of certain chemicals in your brain, called serotonin and noradrenaline/norepinephrine, helping to improve symptoms of depression, anxiety, and nerve pain.
Otros usos
Duloxetine is also prescribed for treating urinary symptoms, although a different brand and strength of capsule are used. There is a separate medicine leaflet called Duloxetina para síntomas urinarios, giving more information about duloxetine when used for this condition.
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Side effects of duloxetine
Volver al contenidoThe most common side effects of duloxetine are:
Náuseas.
Boca seca.
Estreñimiento.
Diarrea.
Feeling dizzy, tired or sleepy.
Dolor de cabeza.
Sudoración.
Feeling anxious or shaky.
Problemas para dormir.
Disminución del deseo sexual (libido).
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
Los efectos no deseados a menudo mejoran a medida que su cuerpo se adapta al nuevo medicamento, pero hable con su médico o farmacéutico si alguno de los siguientes persiste o se vuelve problemático.
How to manage duloxetine side effects
Volver al contenidoVery common duloxetine side effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling sick | Come comidas sencillas - evita alimentos ricos o picantes |
Boca seca | Intenta masticar chicle sin azúcar o chupar caramelos sin azúcar |
Estreñimiento | Intenta comer una dieta equilibrada y beber varios vasos de agua cada día |
Common duloxetine side effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Blurred vision; feeling tired, dizzy or sleepy | Do not drive and do not use tools or machines while affected. Avoid alcohol |
Diarrea | Bebe mucha agua para reponer los líquidos perdidos |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Lack of appetite, indigestion, stomach pain, facial flushing, increased blood pressure, difficulty sleeping, feeling anxious, skin tingling, feeling shaky, reduced interest in sex, increased sweating | Consulte a su médico si alguno de estos le causa molestias |
Importante: if you develop any depressing or distressing thoughts or ideas, you should let your doctor know about this as soon as possible. When this medicine is prescribed for people with depression or anxiety, it can increase the risk of suicidal thoughts, particularly when the treatment is first started.
En raras ocasiones, los medicamentos que afectan el nivel de serotonina en el cerebro pueden hacer que este suba demasiado y cause problemas. El riesgo es mayor si está tomando otro medicamento con este efecto (como un antidepresivo). Busque atención médica si desarrolla alguna combinación de los siguientes síntomas:
Músculos rígidos o movimientos 'bruscos'.
Latidos del corazón inusualmente rápidos.
Alta temperatura (fiebre).
Sentirse mal (náuseas) o estar enfermo (vómitos), diarrea.
Sentirse delirante o ver visiones (alucinar).
If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice
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Who should not take duloxetine?
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking duloxetine it is important that your doctor knows:
Si estás embarazada, intentando tener un bebé o amamantando.
If you have problems with the way your liver works, or with the way your kidneys work.
Si tienes una afección cardíaca.
If you have increased eye pressure (called glaucoma).
Si tienes presión arterial alta.
If you have ever had 'high' moods, such as mania in bipolar disorder.
If you have ever had a fit (seizure).
If you have a blood disorder that increases your risk of bleeding.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take duloxetine
Volver al contenidoRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about duloxetine and will provide you with a full list of the side effects which you may experience from taking it.
Take duloxetine exactly as your doctor tells you to. The usual dose is one capsule of either 30 mg or 60 mg daily.
When starting duloxetine, your doctor may give you the lower strength of capsules to begin with, and then increase the strength as you go on.
Try to take your doses at the same time of day each day, as this will help you to remember to take your doses regularly.
You can take duloxetine either before or after meals. Swallow the capsule whole with a drink of water to help you to swallow it.
If you forget to take a dose at your usual time, take it when you remember. If you do not remember until the following day then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIntenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso y revisar tu tratamiento.
You may feel that duloxetine is not helping you straightaway. If you are taking duloxetine for depression or anxiety, it can take a week or two before the effect builds up and 2-4 weeks before you feel the full benefit.
If you are taking duloxetine for nerve pain damage, it can take several weeks before you feel better. Do not stop taking the capsules after a week or so, even if you think they are not working.
If you are taking duloxetine for depression, you should expect that a normal course of treatment will last for around six months after your symptoms have eased.
There are several types of antidepressants and they differ in their possible side effects - if you find that duloxetine does not suit you then let your doctor know, as another may be found that will.
If you drink alcohol, ask your doctor for advice about drinking while you are on duloxetine. Drinking alcohol can increase the risk of unwanted effects from duloxetine, such as dizziness and blurred vision.
If you buy any medicines, check with a pharmacist that they are suitable to take with duloxetine. This is because some herbal medicines (such as St John's wort) can increase the risk that you will experience unwanted effects.
If you are having an operation or dental treatment, please tell the person carrying out the treatment that you are taking duloxetine.
Keep taking duloxetine until your doctor tells you otherwise. Your treatment is likely to last for a number of months.
Stopping suddenly can cause symptoms such as headache, sickness, anxiety, dizziness, shakiness and sleeping problems. Your doctor will reduce your dose gradually over a week or two to reduce the risk of these sorts of problems.
How to store duloxetine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.
Preguntas frecuentes
Volver al contenidoDoes duloxetine cause weight gain?
Duloxetine is not strongly linked with weight gain, however some people may notice changes in their weight. It's important to speak to your doctor if you're concerned.
What is the most common side effect of duloxetine?
The most common side effect of duloxetine is feeling sick (nausea), although other issues like dry mouth or sleep changes can also occur. These side effects often go away over time.
How long can you take duloxetine for nerve pain?
How long you can take duloxetine for nerve pain depends on your individual needs and how well the medicine works for you. Some people may only need it for a few months, while others stay on it longer to keep their symptoms under control.
Is duloxetine addictive?
Duloxetine is not considered addictive. However, stopping it suddenly can cause withdrawal symptoms such as dizziness, headaches, or irritability. For this reason, your doctor will usually advise reducing the dose gradually if you decide to stop.

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Lecturas adicionales y referencias
- Manufacturer's PIL, Cymbalta® 30 mg hard gastro-resistant capsules, Cymbalta® 60 mg hard gastro-resistant capsules; Eli Lilly and Company Ltd, The electronic Medicines Compendium. Dated June 2024.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Next review due: 24 Aug 2027
17 Ago 2024 | Última versión

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