Methadone oral solution
Metharose, Physeptone
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 14 Sept 2024
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Este medicamento es un analgésico opioide. Existe un riesgo serio de adicción al tomar este medicamento, especialmente si se usa a largo plazo. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued nuevas pautas para personas a las que se les ha recetado un analgésico opioide. Si tiene alguna pregunta o inquietud sobre el uso seguro de opioides, por favor hable con su médico o farmacéutico.
Methadone oral solution is a substitute for street drugs like heroin which cause dependence and addiction.
It is important for you to continue to take methadone regularly, every day.
You are more likely to succeed in staying off heroin if you have support. Please ask about what counselling and help are available in your area.
De un vistazo
Methadone is a medicine used to treat opioid dependence and addiction.
It helps prevent withdrawal symptoms and is usually taken once daily as an oral liquid.
You will be supervised when you first start taking methadone to ensure correct dosage.
Do not drink alcohol or take street drugs with methadone due to increased overdose risk.
Do not stop taking methadone without discussing it with your doctor.
If you suspect an overdose, seek immediate medical help.
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About methadone
Tipo de medicamento | An opioid substitution therapy |
Usado para | To help manage opioid dependence and addiction in adults (such as heroin addiction) |
También llamado | Metharose®, Physeptone® |
Disponible como | Oral solution, tablets |
Methadone is prescribed to help you keep off drogas callejeras such as heroin. It can help to prevent the unpleasant withdrawal symptoms which can occur when you stop using drugs like these. It is taken by mouth as an oral liquid and it works as a substitution treatment. Many people choose to stay on methadone long-term, although some people gradually reduce their dose and come off it.
The effects of methadone last longer than heroin so it is usually prescribed as a once-daily dose. To begin with, you will usually be asked to take it under the supervision of the person who dispenses the methadone to you. This means there can be no doubt about how much methadone you take at each dose. This supervision may be relaxed after a few months of you taking a regular maintenance dose.
Methadone also acts as a painkiller. It is occasionally used to treat severe pain if other strong painkillers are unsuitable. If you have been prescribed methadone for this reason then you should speak with your doctor or home-care team if you have any questions about your treatment. This document gives information about methadone when it is used to manage drug addiction only.
Before taking methadone
Volver al contenidoTo make sure that this is the right treatment for you, before you start taking methadone it is important that your doctor or pharmacist knows:
Si estás embarazada o amamantando.
Si tienes problemas de próstata o alguna dificultad para orinar.
Si tienes algún problema respiratorio, como asma o enfermedad pulmonar obstructiva crónica (EPOC).
If you have been told you have low blood pressure or an unusual heart rhythm.
Si tienes algún problema con tu tiroides o glándulas suprarrenales.
If you have fits or epilepsy.
If you have a problem with the way your liver works or a problem with the way your kidneys work.
Si tienes un problema con tu conducto biliar.
Si has estado estreñido por más de una semana o tienes un problema inflamatorio intestinal.
Si tienes una condición que causa debilidad muscular, llamada miastenia gravis.
Si recientemente has tenido una lesión grave en la cabeza.
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
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How to take methadone
Volver al contenidoCarefully follow the advice your doctor has given to you and read any printed information you have been given. The manufacturer's printed information leaflet (which will be supplied with the medicine) will give you more information about methadone and will provide you with a full list of the side-effects which you could experience from taking it.
Take methadone exactly as your doctor tells you to. Do not take more, or less, than the dose you have been prescribed. It is usually prescribed as a once-daily dose
Try to take your dose at the same time of day, each day. Initially you will be asked to take methadone where you can be supervised. This is to help you stick with your treatment and make sure you do not miss any doses.
At first your doctor will prescribe a low-ish dose and then see you frequently to adjust this to a regular maintenance dose. This early stage is very important because too high a dose can cause you serious harm, so please be patient. It may take a few weeks until the correct dose is found and you may have some minor withdrawal symptoms during this time. The correct dose varies from person to person, depending on how much heroin you were using and how your body deals with (metabolises) methadone.
If you miss a dose, wait until it is time for your next dose and take this next dose when it is due. Do reportado take two doses together to make up for a missed dose. It is important that you tell your doctor you have missed a dose. If you miss more than three days of methadone, your dose will need to be changed.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIt is important that you keep your regular appointments with your doctor/clinic so that your progress can be reviewed. You will be asked to give a urine sample from time to time.
You are more likely to succeed in staying off heroin if you have support and counselling. Local drug community teams, self-help groups and other agencies can be of help. It is much harder to 'do it alone', so go for counselling and help if it is available in your area.
Methadone causes drowsiness and will affect your ability to drive. It is against the law to drive if your driving ability is impaired by this medicine. Even if your driving is not impaired, you will be guilty of an offence unless the methadone has been prescribed for a medical reason y it has been taken according to the instructions given by the prescriber.
Do not take more than the dose your doctor has prescribed for you. Signs of overdose can include pinpoint pupils, shallow breathing and, eventually, unconsciousness. If you suspect that you or someone else might have had an overdose of methadone, contact a doctor or go to the accident and emergency department of a local hospital straightaway. Take the container with you, even if it is empty.
You should not take any street drugs or drink alcohol while you are on methadone. This is because other street drugs and/or alcohol can increase the risk of overdose and side-effects.
Methadone (even in small amounts) is a special hazard to children and other people if it is swallowed by accident. If you suspect that someone else has swallowed some methadone, please get medical help straightaway.
Do not stop taking methadone without discussing this with your doctor or drug-team worker first. It is important that methadone should be taken regularly to reduce the risk of withdrawal symptoms from occurring. Withdrawal symptoms from methadone are similar to those from heroin (they are less severe but last longer). When you are ready to consider becoming drug-free, your doctor or drug-team worker will be able to help you decide on the best way to do this in order to keep withdrawal effects to a minimum.
If you buy any medicines, please check with a pharmacist that they are safe to take with methadone.
If you are having an operation or dental treatment, please tell the person carrying out the treatment that you are taking methadone. It could interfere with an anaesthetic, if needed.
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Can methadone cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with methadone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common methadone side-effects | ¿Qué puedo hacer si experimento esto? |
Feeling sick (nausea) or being sick (vomiting), tummy (abdominal) pain | Mantente con comidas simples - evita alimentos ricos o picantes |
Estreñimiento | Come una dieta equilibrada y bebe mucha agua cada día |
Feeling dizzy, faint or sleepy | Do not drive and do not use tools or machines. Do not drink alcohol |
Boca seca | Intenta masticar chicle sin azúcar o chupar caramelos sin azúcar |
Other effects include: difficulty passing urine, mood changes, flushing, hypothermia, slow heartbeat, dry eyes and feeling restless | If any of these become particularly troublesome, speak with your doctor |
Importante: people taking opioid painkillers, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy. Signs you have taken too much medicine include:
Sintiéndose muy somnoliento o mareado.
Sentirse mal (náuseas) o estar enfermo (vómitos).
Dificultades para respirar.
Pérdida de conciencia.
If you have taken more medication than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.
If you experience any other symptoms which you think may be due to methadone, please speak with your doctor, clinic or pharmacist for further advice.
How to store methadone
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
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Preguntas frecuentes
How does methadone help stop heroin withdrawal symptoms?
Methadone is prescribed to help manage opioid dependence and addiction by preventing the unpleasant withdrawal symptoms that can occur when you stop using drugs like heroin. It works as a substitution treatment and its effects last longer than heroin, so it is usually taken once daily.
Why is methadone supervision necessary, and will it always be required?
Initially, you will usually be asked to take methadone under supervision, meaning someone will dispense it to you. This is to ensure the correct dose is taken and to help you stick with your treatment. This supervision may be relaxed after a few months once you are on a regular maintenance dose.
What should I do if I miss a dose of methadone?
If you miss a dose, you should wait until it's time for your next scheduled dose and take that dose as usual. Do not take two doses together to compensate for the missed one. It's important to tell your doctor if you miss a dose. If you miss more than three days of methadone, your dose will need to be adjusted by your doctor.
Can I drive while taking methadone?
Methadone can cause drowsiness and will affect your ability to drive. It is against the law to drive if this medicine impairs your driving ability. Even if your driving is not impaired, you could be committing an offence unless the methadone has been prescribed for a medical reason and you have taken it according to your prescriber's instructions.
What are the risks of taking other street drugs or alcohol with methadone?
You should not take any street drugs or drink alcohol while on methadone. Doing so can increase the risk of overdose and worsen side-effects. Always avoid mixing methadone with other substances.
What should I do if someone accidentally swallows my methadone?
Methadone, even in small amounts, poses a significant hazard if swallowed by children or other people. If you suspect that someone else has swallowed methadone, you must get medical help straightaway.
What if I experience side-effects like feeling sick, constipation, or dizziness?
Many common side-effects improve as your body adjusts to methadone. If you feel sick or are being sick, try to stick to simple meals and avoid rich or spicy foods. For constipation, eat a well-balanced diet and drink plenty of water. If you feel dizzy, faint, or sleepy, do not drive or operate machinery, and avoid alcohol. If any side-effects continue or become troublesome, speak with your doctor or pharmacist.
How long will it take to find the correct dose of methadone for me?
Initially, your doctor will prescribe a low dose and will see you frequently to adjust it to a regular maintenance dose. This early stage is crucial because too high a dose can be dangerous. It may take a few weeks until the correct dose is found, and you might experience some minor withdrawal symptoms during this period. The correct dose is unique to each person, depending on their previous heroin use and how their body processes methadone.
What should I do if I need an operation or dental treatment while on methadone?
If you are having an operation or dental treatment, it is very important to tell the person carrying out the treatment that you are taking methadone. This is because methadone could interfere with an anaesthetic if one is needed.
Lecturas adicionales y referencias
- Manufacturer's PIL, Methadone 1 mg/ml Oral Solution BP - Sugar Free; Martindale Pharma Ltd, The electronic Medicines Compendium. Dated May 2023.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 12 de septiembre de 2027
14 Sept 2024 | Última versión

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