Doxepin capsules
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización: 7 de agosto de 2023
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Doxepin may make you feel sleepy. If this happens, do not drive and do not use tools or machines. Do not drink alcohol.
Informe a su médico si experimenta algún efecto secundario molesto.
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About doxepin
Tipo de medicamento | Un antidepresivo tricíclico |
Utilizado para | The treatment of depression in adults aged 18 and over |
Disponible como | Cápsulas |
Doxepin belongs to a group of medicines called tricyclic antidepressants. It is prescribed for the treatment of depression. The exact cause of depression is not known. It can develop for no apparent reason or it may be triggered by a life event such as a relationship problem, bereavement, or illness. With depression you have a consistently low mood and other symptoms severe enough to interfere with your normal day-to-day activities.
Doxepin can help ease the symptoms of depression. It is particularly helpful if you also have difficulty sleeping. It is thought to work by interfering with brain chemicals (called neurotransmitters) which may be involved in causing the symptoms.
Before taking doxepin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking doxepin it is important that your doctor knows:
Si está embarazada o en periodo de lactancia.
Si tiene una glándula tiroides hiperactiva.
Si tiene algún problema con el funcionamiento del hígado o de los riñones.
Si padece epilepsia o diabetes (diabetes mellitus).
If you have had problems with constipation over a long time.
Si tiene dificultades para orinar o si ha tenido problemas de próstata.
Si padece un trastorno cardíaco o una enfermedad vascular.
If you have had a mental health problem - in particular, bipolar disorder or psychosis.
If you have increased pressure in your eyes (glaucoma).
If you have been told you have phaeochromocytoma - a tumour on your adrenal gland.
If you have porphyria - a rare inherited blood disorder.
Si está tomando otros medicamentos, incluidos los que se pueden comprar sin receta, así como hierbas medicinales y medicamentos complementarios. Esto es especialmente importante si ha tomado recientemente un medicamento para la depresión, conocido como inhibidor de la monoaminooxidasa (IMAO).
Si alguna vez ha tenido una reacción alérgica a un medicamento.
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How to take doxepin capsules
Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about doxepin and will provide you with a full list of the side-effects which you may experience from taking it.
Doxepin can make you feel sleepy so your doctor may advise you to take a small dose when you first start taking it, and then to increase your dose gradually as your body gets used to it.
Doxepin is often prescribed once a day at bedtime, although it can also be taken two or three times a day. Your doctor will tell you which is right for you and the directions will be printed on the label of the pack to remind you what the doctor has said. If you have any questions about how to take the capsules, ask your pharmacist for advice.
You can take doxepin before or after meals. Many people find if helps to swallow the capsule with a drink of water.
If you forget to take a dose, take it as soon as you remember unless your next dose is due. If it is nearly time for your next dose, then take the next dose when it is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
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You may feel that doxepin is not working for you straightaway. It can take a week or two for the effect to build up, and 4-6 weeks before you feel the full benefit. It is important that you do not stop taking it thinking that it is not helping.
While you feel depressed, you may have distressing thoughts and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway.
If you drink alcohol, ask your doctor for advice. Your doctor is likely to recommend that you do not drink alcohol while you are on doxepin as it increases the risk of side-effects, such as feeling sleepy.
There are several types of antidepressants - each type works in a slightly different way and can have different side-effects. If you find that doxepin does not suit you then let your doctor know, as another antidepressant may be found that does.
Some people who take doxepin find that their skin becomes more sensitive to sunlight than usual. Do not use sunbeds and try to avoid strong sunlight until you know how your skin reacts. Use a sun cream with a high sun protection factor.
Your doctor may ask you to carry on taking doxepin even after you feel better. This is to help stop your symptoms from returning.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because a number of medicines can increase the risk of side-effects from doxepin, including some painkillers, flu remedies and antihistamines which can be bought from pharmacies.
If you have diabetes you may need to check your blood sugar (glucose) more frequently. This is because doxepin can alter the levels of sugar in your blood. Your doctor will advise you about this.
If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking a tricyclic antidepressant, as they can interfere with some anaesthetics.
Continue to take doxepin unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor may want you to reduce your dose gradually if this becomes necessary.
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Can doxepin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with doxepin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common doxepin side-effects | ¿Qué puedo hacer si me ocurre esto? |
Blurred vision, feeling sleepy or tired | Si esto ocurre, no conduzca ni utilice herramientas o máquinas. No bebas alcohol |
Boca seca | Prueba a mascar chicle sin azúcar o chupar caramelos sin azúcar |
Estreñimiento | Try to eat a well-balanced diet containing plenty of fibre and drink plenty of water |
Feeling faint or light-headed, especially when getting up from a sitting or lying position | Levantarse más despacio puede ayudar. Si empieza a sentirse débil, siéntese hasta que se le pase la sensación. |
Dolor de cabeza | Pida a su farmacéutico que le recomiende un analgésico adecuado |
Sentirse mal (náuseas) o estar enfermo (vómitos), diarrea | Limítese a comidas sencillas: evite los alimentos ricos o picantes. Beba mucha agua para reponer los líquidos perdidos. |
Sweating, flushing, difficulty in passing urine, increased appetite, feeling confused or anxious, disturbed sleep, lack of concentration, feeling shaky, itchy skin rash, weight changes, changes in sexual function, breast tenderness, changes in the way things taste, ringing in your ears, fast heartbeat | Si alguno de estos síntomas le resulta molesto, consulte a su médico. |
Important: On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:
Rigidez muscular o movimientos bruscos.
Latidos del corazón inusualmente rápidos.
Temperatura alta (fiebre), sensación de malestar (náuseas) o estar enfermo (vómitos), diarrea.
Delirios o visiones (alucinaciones).
Si experimenta cualquier otro síntoma que considere que puede deberse al medicamento, consulte a su médico o farmacéutico.
How to store doxepin capsules
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda inmediatamente al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.
Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.
No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.
Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.
Informar de los efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.
Lecturas complementarias y referencias
- Manufacturer's PIL, Doxepin 25 mg and 50 mg Capsules; Marlborough Pharmaceuticals Ltd, The electronic Medicines Compendium. Dated May 2021.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Fecha de la próxima revisión: 6 de agosto de 2026
7 ago 2023 | Última versión

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