Amantadine
Trilasym
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 14 Sept 2024
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For relief of Parkinson's disease symptoms, amantadine is usually taken once or twice daily.
Short courses of amantadine can be used to prevent the rash and pain caused by shingles infection (herpes zoster).
The most common side-effects are swollen ankles and red skin blotches. It can also cause drowsiness and blurred vision, so please take care when using tools or machines.
About amantadine
Tipo de medicamento | A dopamine agonist |
Usado para | Parkinson's disease; Prevention of shingles rash and nerve pain |
También llamado | Trilasym® |
Disponible como | Capsules and oral liquid medicine |
Amantadine can be prescribed to relieve the symptoms of enfermedad de Parkinson, although other treatments are often preferred.
Parkinson's disease affects the way your brain co-ordinates the movements of your muscles. Nerve messages to the muscles become slowed and abnormal. This leads to symptoms such as shaking (tremor), muscle stiffness, and slow movement. Amantadine helps to ease these symptoms. It is usually prescribed alongside other medicines used for the treatment of Parkinson's disease.
Amantadine can also be prescribed to help lessen or prevent the rash and nerve pain that is often caused by shingles (herpes zoster). The medicine is given to people at risk of a severe or painful rash.
If you have been prescribed amantadine for any other reason, speak to your doctor or a pharmacist if you have any questions.
Before taking amantadine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking amantadine it is important that your doctor knows:
Si estás embarazada o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
Si tienes una afección cardíaca.
If you have fits, or epilepsy.
If you have increased pressure in your eyes (glaucoma).
Si alguna vez has tenido una úlcera estomacal.
If you feel confused, or if you see or hear things that are not real (hallucinations).
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
How to take amantadine
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack and any additional information your doctor has given to you. These will give you more information about amantadine and will provide you with a full list of the side-effects which you may experience from taking it.
Take amantadine exactly as your doctor tells you to.
If you have been prescribed amantadine for Parkinson's disease symptoms it is usual to take 100 mg daily (one capsule or two 5 ml spoonfuls) for the first week, and then for the dose to increase to twice a day. Some people may require doses of up to 400 mg daily.
If you have been prescribed amantadine to prevent a shingles rash and nerve pain (neuralgia posherpética) the dose is 100 mg twice a day for 14 days. If you are still in pain after 14 days a further course of treatment may be prescribed.
Your doctor or pharmacist will tell you what dose to take each day, and the directions will also be printed on the label of the pack to remind you about what the doctor said to you.
Try to take your doses of amantadine at the same time(s) each day, as this will help you remember to take it regularly.
If you forget to take a dose, take it as soon as you remember. Try to take the correct number of doses each day but do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Sometimes people taking medicines like amantadine can fall asleep suddenly with little or no warning of being tired beforehand. Until you know how you react, take extra care if you operate machinery or drive. If you do find yourself falling asleep suddenly, you should see your doctor as soon as possible for advice, and avoid driving or using tools and machines in the meantime.
For people with Parkinson's disease
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. During the first few weeks of treatment in particular, your dose may require adjusting.
Stay as active as possible and exercise regularly as much as you are able. You may walk more slowly than before but a daily walk is good exercise and may help to loosen up stiff muscles.
If you are a driver you should tell the DVLA and your insurance company that you have Parkinson's disease. Depending on the severity of symptoms and the medicines that you are taking, you may still be allowed to drive following a medical assessment.
Treatment with medicines for Parkinson's disease can sometimes cause problems with impulsive types of behaviour. If you notice any changes in your behaviour, such as an increased desire to gamble, binge eat, or spend excessively, or an increased sex drive, you must let your doctor know as soon as possible.
Continue to take amantadine regularly. Stopping treatment suddenly can cause serious problems. Your doctor will probably want you to reduce your dose gradually if this becomes necessary.
Can amantadine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the common ones associated with amantadine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common amantadine side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Swollen ankles, red skin blotches | Si es problemático, hable con su médico |
Common amantadine side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Loss of appetite, feeling sick (nausea), constipation | Come una dieta equilibrada y bebe mucha agua |
Blurred vision; feeling dizzy, light-headed or tired | No conduzca ni utilice herramientas o máquinas mientras esté afectado. No consuma alcohol |
Boca seca | Intenta masticar chicle sin azúcar o chupar caramelos sin azúcar |
Headache, muscle pain | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Feeling anxious or confused, changes in your mood, difficulties sleeping, lack of concentration, slurred speech, a fast heartbeat, increased sweating, hearing or seeing things that are not real (hallucinations) | Si alguno de estos se vuelve problemático, hable con su médico |
If you experience any other symptoms which you think may be due to amantadine, speak with your doctor or pharmacist for further advice.
How to store amantadine
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
The oral liquid medicine will keep for one month after first opening. Do not use any remaining medicine after this time. It is a good idea to write the date you opened the bottle on the label.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Si vas a someterte a una operación o a un tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
Si compras algún medicamento, siempre consulta con un farmacéutico que sea seguro tomarlos junto con tus otros medicamentos.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, donde se encargarán de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.
Preguntas frecuentes
Can amantadine cure Parkinson's disease or shingles?
No, amantadine is used to relieve the symptoms of Parkinson's disease and to help lessen or prevent the rash and nerve pain associated with shingles. It does not cure either condition.
How long will I need to take amantadine for Parkinson's disease?
The article states that for Parkinson's disease, you should continue to take amantadine regularly and that stopping treatment suddenly can cause serious problems. Your doctor will likely want you to gradually reduce your dose if it becomes necessary to stop. This implies it's a long-term treatment, but the exact duration should be discussed with your doctor.
What should I do if I forget to take my amantadine dose?
If you forget to take a dose, you should take it as soon as you remember. However, it's important to try and take the correct number of doses each day and not to take two doses together to make up for a missed dose.
Are there any specific lifestyle changes I should make while taking amantadine for Parkinson's disease?
Yes, it's recommended to stay as active as possible and exercise regularly as much as you are able. Even a daily walk can be beneficial for loosening up stiff muscles. If you are a driver, you should inform the DVLA and your insurance company about your Parkinson's disease.
Why do I need to tell my doctor about other medicines I'm taking, even non-prescription ones?
It's important to tell your doctor about all other medicines you are taking, including non-prescription, herbal, and complementary medicines, because some medicines are not suitable to be taken with amantadine or may require extra care. This helps your doctor ensure the treatment is safe and effective for you.
Lecturas adicionales y referencias
- Manufacturer's PIL, Amantadine hydrochloride 100 mg capsules; Alliance Pharmaceuticals, The electronic Medicines Compendium. Dated April 2024.
- Manufacturer's PIL, Amantadine hydrochloride 50 mg/5 ml oral solution; Northumbria Pharma Ltd, The electronic Medicines Compendium. Dated May 2023.
- Medicamentos Completo BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
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