Dolutegravir for HIV

About dolutegravir

Dolutegravir is an antiretroviral medicine. It is used for infección por el virus de la inmunodeficiencia humana (VIH). It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Dolutegravir is known as an integrase inhibitor antiretroviral medicine. It works by stopping an enzyme which is produced by the virus from working. The virus produces the enzyme to help it multiply in the body, so by preventing it from working, dolutegravir reduces the amount of virus in your body. This helps to maintain the health of your immune system.

Dolutegravir will be prescribed for you by a doctor who is a specialist. It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. It is vital to take them exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking dolutegravir it is important that your doctor knows:

• Si estás embarazada, intentando concebir o amamantando.

• Si tienes algún problema con el funcionamiento de tu hígado.

• Si alguna vez has tenido una reacción alérgica a un medicamento.

• Si está tomando otros medicamentos. Esto incluye cualquier medicamento que se pueda comprar sin receta, así como medicamentos herbales y complementarios.
  

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about dolutegravir, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take dolutegravir exactly as your doctor tells you to. The usual dose is one 50 mg tablet, taken either once or twice a day. The right dose for you will depend upon what other medicines you are taking for HIV.

• If you have been prescribed 5 mg dispersible tablets your daily dose in milligrams will be lower but you will need to take more tablets each day. Follow your doctor's directions closely. Do not take a mixture of normal tablets and dispersible tablets; they do not work in the same way.

• Try to take the tablet at the same time(s) of day each day, as this will help you to remember to take dolutegravir regularly. If you forget to take a dose at your usual time, take it as soon as you remember (unless it is within four hours of your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.

• Swallow the tablets whole with a drink of water.

• If you have been prescribed dispersible (soluble) tablets these can be swallowed whole or dissolved in water first. Follow the manufacturer's instructions closely; the amount of water you need will depend on how many tablets you need for each dose. Do not chew, cut or crush the dispersible tablets. Allow the tablets to dissolve for 1-2 minutes and gently swirl the measuring cup to ensure they are fully dissolved before swallowing.

• Dolutegravir can be taken either with or without food, but if you are known to have resistance to some treatments, your doctor will advise you to always take your doses after a meal as it can increase the effectiveness of the tablets.

• Mantén tus citas regulares con tu médico para que se pueda monitorear tu progreso. Necesitarás hacerte análisis de sangre regularmente.

• It is important that you continue to take dolutegravir and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop any infection soon after you start the treatment, let your doctor know. As a result of taking dolutegravir, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Siga cuidadosamente cualquier consejo que le dé su médico sobre hacer cambios en su estilo de vida para reducir cualquier riesgo de daño a su corazón y vasos sanguíneos. Estos pueden incluir dejar de fumar, comer saludablemente y hacer ejercicio regularmente.

• Although treatment with antiretroviral medicines can reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is important that you use condoms.

• Dolutegravir can harm an unborn child so you must avoid getting pregnant while you are taking dolutegravir. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you are a woman and want to have a family, discuss this with your doctor so that you can be given advice from a specialist about alternative treatment before you become pregnant.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression you should speak with your doctor de inmediato.

• Algunas personas que han tomado medicamentos antirretrovirales (particularmente durante un largo período) han desarrollado una condición llamada osteonecrosis. Esta es una enfermedad ósea donde el tejido óseo muere debido a una reducción en el suministro de sangre. Esto lleva a dolores articulares y rigidez, y puede causar dificultades en el movimiento. Si nota alguno de estos síntomas, hable con su médico.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with dolutegravir and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly. Dolutegravir should not be taken with antacid remedies: if you need to take an antacid, you should take it six hours before you take a dose of dolutegravir, or wait until two hours afterwards. Vitamin and mineral supplements must also be taken well separated from dolutegravir.

• Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.

• Treatment for HIV is usually lifelong. Continue to take dolutegravir regularly, even if you feel well. This is to keep your immune system healthy.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with dolutegravir. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Importante: although it is common for people taking dolutegravir to develop a skin rash, a severe rash with blisters may be a sign of a more serious allergic-type reaction. Let your doctor know de inmediato if you develop the following:

• Severe blistering rash with high temperature (fever), muscle and joint aches or pains, feeling generally unwell, mouth ulcers, conjunctivitis, dark urine, stomach pain, yellowing of your skin or the whites of the eyes (jaundice).

If you experience any other symptoms which you think may be due to dolutegravir, speak with your doctor or pharmacist for further advice.

• Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

• Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

• The bottle of 10 mg tablets contains a small 'desiccant' container to protect the tablets from moisture. Do not remove the desiccant container from the bottle, but take care not to swallow it. Keep the bottle tightly closed when not in use.