Meperidine for pain relief
Demerol
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 27 de febrero de 2023
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This medicine is a strong opioid painkiller (narcotic analgesic). There is a serious risk of addiction when taking this medicine, especially if used long-term. If you have any questions or concerns about taking opioids safely please speak with your physician or a pharmacist.
Meperidine is used to relieve pain, particularly during childbirth.
Por lo general, se administra mediante inyección y proporciona alivio del dolor durante hasta cuatro horas.
The most common side-effects are feeling dizzy or sleepy, sweating and nausea.
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Video picks for Analgésicos y medicamentos para el dolor
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About meperidine
Tipo de medicamento | A strong opioid painkiller (narcotic analgesic) |
Usado para | Alivio del dolor |
También llamado | Demerol® |
Disponible como | Tabletas, medicina líquida oral e inyección |
Strong opioids (narcotic analgesics) are medicines used to treat severe pain. Although there are a number of narcotic analgesics, meperidine (also known as pethidine) is the one that has been traditionally used during el parto, as its effects are shorter-lasting than some of the others. It works on your nervous system and brain to reduce the amount of pain you feel. Meperidine can be taken by mouth as a tablet or liquid medicine, but during childbirth it is more usually given as an injection.
Before having meperidine
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking meperidine it is important that your physician knows:
If you are pregnant (other than during labor) or breastfeeding.
Si tienes problemas de hígado o riñón.
Si tienes problemas de próstata o alguna dificultad para orinar.
Si tienes algún problema respiratorio, como asma o enfermedad pulmonar obstructiva crónica (EPOC).
If you have been told you have low blood pressure (hypotension).
Si tienes algún problema con tu tiroides o glándulas suprarrenales.
Si tienes epilepsia.
Si tienes un problema con tu conducto biliar.
Si has estado estreñido por más de una semana o tienes un problema inflamatorio intestinal.
Si tienes una condición que causa debilidad muscular, llamada miastenia gravis.
Si recientemente has tenido una lesión grave en la cabeza.
Si alguna vez has sido dependiente de las drogas o el alcohol.
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
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How meperidine is given
Volver al contenidoBefore you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about meperidine and will provide you with a full list of the side-effects which you may experience from having it.
If you have been prescribed meperidine injection, this will be given to you by your physician or nurse. It will be injected under your skin or into a muscle. The injections can be repeated every few hours during labor, if needed. If you are being given meperidine for other types of pain (such as after surgery), the injection can be repeated every three to four hours.
If you have been prescribed meperidine tablets, take the tablets exactly as your physician has told you to. The usual dose of meperidine is between one and three 50 mg tablets.
If you have been prescribed meperidine oral liquid medicine, take the liquid exactly as your physician tells you to. Use a measuring cup or oral syringe to measure the correct amount of liquid. The measured dose should be mixed in half a glass of water before swallowing. This is because swallowing undiluted meperidine liquid can numb the mouth.
When taking meperidine by mouth, the dose should not be repeated more frequently than every three to four hours.
If you forget to take a dose, take it as soon as you remember and then continue taking your doses every three to four hours from that point. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoAsk your physician for advice before drinking alcohol. Your physician may recommend that you do not drink alcohol for a while after you have had meperidine because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that meperidine is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, you are advised to carry with you some evidence that the medicine has been prescribed for you - a prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are planning a trip abroad and need to take meperidine with you, you are advised to carry a letter with you from your physician to explain why you have been prescribed it. This is because meperidine is classed as a 'controlled drug' and is subject to certain restrictions.
You will not be given meperidine tablets or liquid for longer than is necessary. This is because repeatedly using meperidine over a period of time can lead to your body becoming dependent on it. When you then stop taking it, it will cause withdrawal symptoms such as restlessness and irritability. If you are concerned about this, discuss it with your physician or pharmacist. This will not become a problem if you are receiving a dose or two of meperidine during labor.
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Can meperidine cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with meperidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common meperidine side-effects | ¿Qué puedo hacer si experimento esto? |
Náuseas o vómitos | Opta por alimentos sencillos. Bebe mucha agua para reponer los líquidos perdidos |
Sentirse mareado, somnoliento o con sueño | Si esto ocurre, no conduzca y no utilice herramientas o máquinas. No consuma alcohol |
Other common side-effects include headache, dry mouth, constipation, feeling flushed, itchy skin rash, sweating, feeling confused, difficulties passing urine, shallow breathing | If any of these occur, speak with your physician |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store meperidine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the Emergency Room of your local hospital. Take the container with you, even if it is empty.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
If you are having surgery or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Si compras algún medicamento, consulta con un farmacéutico que sean adecuados para tomar con tus otros medicamentos.
No conserve medicamentos caducados o no deseados. Pregunte a su farmacéutico sobre las formas de desechar los medicamentos de manera segura en su área local.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- FDA Drug Label, Demerol® 50 mg and 100 mg Tablets; Validus Pharmaceuticals LLC, DailyMed, National Institutes of Health, US National Library of Medicine. Dated March 2021.
- FDA Drug Label, Meperidine 50 mg/5 ml Oral Solution (50 mg and 100 mg Tablets); Boehringer Ingelheim, DailyMed, National Institutes of Health, US National Library of Medicine. Dated May 2006.
- FDA Drug Label, Meperidine 25 mg/ml, 50 mg/ml, 100 mg/ml Injection; Hikma Pharmaceuticals USA Inc., DailyMed, National Institutes of Health, US National Library of Medicine. Dated April 2022.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Siguiente revisión prevista: 26 de agosto de 2027
27 de febrero de 2023 | Última versión
1 Mar 2017 | Publicado originalmente
Escrito por:
Michael Stewart, MRPharmS

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