Mucormycosis

Synonyms include zygomycosis and phycomycosis

Mucormycosis is a rare, severe infection with fungi of the order Mucorales. Rhizopus are the most common species, with Rhizomucor, Cunninghamella, Saksenaea, and Apophysomyces species occurring less often.

These fungi are common environmental organisms that only cause disease when immunity is impaired. The spores grow, and fungal hyphae invade blood vessels and produce tissue infarction. The result can be invasive, life-threatening disease. Severe infection of the facial sinuses may extend into the brain. Less common manifestations are pulmonary, cutaneous and gastrointestinal (GI) infections.

Epidemiología

The condition is very rare but often unrecognised. Invasive fungal infections have always been a problem in the immunocompromised, typically aspergillosis and candidiasis, but mucormycosis has also increased in incidence over the last decade.¹ An estimate of annual incidence in the USA was 1.7 infections per million population.²

Factores de riesgo

Impaired immunity from various causes:³

• Poorly controlled diabetes mellitus, especially diabetic ketoacidosis.⁴

• Steroid use.⁵

• Neutropenia, especially with haematological malignancy.⁶

• AIDS.

• Renal insufficiency.⁷

• Organ or stem cell transplantation.⁷

• Iron overload.¹

• Burns.⁵

• Broad-spectrum antibiotics.¹

• Malnutrición.

• Extremes of age.

• Intravenous drug abuse.

• Use of voriconazole for prophylaxis or treatment of aspergillosis.

Extremely rarely, trauma and the use of contaminated medical supplies over wounds are associated with cutaneous mucormycosis in non-immunosuppressed individuals, but not the disseminated form of disease.

Presentación⁸

Historia

• There is usually a fulminant course with considerable tissue necrosis.

• Pyrexia is usual.

• In rhinocerebral disease there is unilateral, retro-orbital headache and nasal stuffiness progressing to a black discharge.

• Late symptoms from invasion of the orbital nerves and vessels include diplopia and visual field loss.

• These are late symptoms with a poor prognosis and usually are followed by reduced consciousness.

• Pulmonary mucormycosis presents nonspecifically with fever, dyspneoa, and cough.

• Cutaneous mucormycosis produces cellulitis that progresses to dermal necrosis and black eschar formation.

• Gastrointestinal (GI) mucormycosis occurs with severe malnutrition and may occur throughout the GI tract. Presentation is nonspecific, with abdominal pain, abdominal distension, nausea, and vomiting.

Examen

Only the signs of rhinocerebral mucormycosis are characteristic:

• Cellulitis of the orbit and face progress with discharge of black pus from the palate and nose.

• Retro-orbital extension produces proptosis, chemosis, ophthalmoplegias and blindness.

• As the brain is involved, there are decreasing levels of consciousness.

Pulmonary and GI symptoms are nonspecific but black, necrotic lesions of the skin indicate cutaneous disease.

Diagnóstico diferencial

May include, dependent on presentation:

• Ántrax

• Bacterial cellulitis

• Cavernous sinus thrombosis

• Aspergilosis

• Rapidly growing orbital tumour

• Embolia pulmonar

• Bowel obstruction

Investigaciones

• FBC

• Renal function (high doses of amphotericin B will be required and it is nephrotoxic).

• Diabetic control (blood glucose, bicarbonate, and electrolytes, blood gases, HbA1c).

• Ferritin and studies of iron status.

• Imaging - both CT and MRI scans are useful to assess the skull, sinuses and brain (in general, CT is better for viewing bone and MRI gives better pictures of brain and soft tissues).

• CXR and chest CT (if chest disease is suspected).

• Abdominal CT (may show a mass by the gut).

• Tissue biopsy and microbiology (hyphae must be demonstrated to start treatment swiftly; culture is also required to determine the species but will take longer).⁹

Gestión

General principles of treatment:²

• Early diagnosis and initiation of treatment - need to consider diagnosis early and for rapid diagnostic tests. Rapid polymerase chain reaction (PCR) based assays are being developed. Prompt initiation of polyene therapy improves prognosis.

• Reversal of underlying disease - eg rectify any poor control of diabetes, reduce immunosuppressant agents (where possible), stop deferoximine.

• Surgical management - debridement of necrotic areas improves antifungal penetration. The optimum timing of surgical debridement is not well defined. For rhinocerebral disease, surgery includes drainage of the sinuses and may require excision of the eye, other orbital contents, and involved brain. Surgery may be quite destructive and may need to be repeated. Pulmonary lesions can be excised if confined to a single lobe

• Primary antifungal therapy - usually high-dose liposomal amphotericin B for at least 4-6 weeks. A new oral antifungal is posaconazole: it appears to be useful for step-down or salvage therapy after initial amphotericin B treatment but it is unclear as yet if it is effective primary therapy.¹⁰ The use of combination regimes is being explored.

• Adjunctive therapy - agents such as hyperbaric oxygen, interferon-γ, granulocyte-macrophage colony stimulating factor and iron chelation with deferasirox¹¹ may be beneficial but their use remains experimental.¹²

Complicaciones

There is massive invasion and infarction of local tissues.

Pronóstico⁸

Mucormycosis has a very high mortality rate of at least 50%. Mortality from pulmonary and gastrointestinal (GI) disease is even higher due to late diagnosis. In patients who survive rhinocerebral disease, treatment requires extensive and often disfiguring facial surgery. In an Italian study 65% of diagnoses were made postmortem¹³ although, in many, empirical antifungal treatment has already been given. Mortality in transplant patients can be 80%.