Zafirlukast para el asma
Accolate
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 3 Sept 2024
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Clinical author's note
Michael Stewart 12/9/2018: Accolate® tablets were discontinued in the UK in March 2018. At the time of review there are no branded or generic products containing zafirlukast available in the UK. Zafirlukast may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Take zafirlukast twice daily, one tablet in the morning and one in the evening.
Tu médico te recetará un inhalador de alivio para que lo uses en caso de que tengas un ataque de asma. Asegúrate de llevarlo contigo todo el tiempo.
The most common side-effects are high temperature (fever) and frequent sore throats and infections.
De un vistazo
Zafirlukast is a medicine used to treat asthma in adults and children over 12 years old.
It helps control asthma symptoms by blocking chemicals called leukotrienes in the body.
Take one tablet in the morning and one in the evening, on an empty stomach.
Zafirlukast will not provide immediate relief during an asthma attack; use your reliever inhaler for this.
Contact your doctor if your asthma symptoms worsen or if you need your reliever inhaler more often.
Possible side-effects include fever, sore throat, headache, and tummy upset.
Seek medical advice immediately if you experience yellow skin or eyes, or flu-like symptoms with tingling.
About zafirlukast
Tipo de medicamento | Un antagonista del receptor de leucotrienos |
Usado para | Asthma (for adults and for children aged over 12 years) |
También llamado | Accolate® (discontinued in UK) |
Disponible como | Comprimidos |
Asma is a common condition caused by inflammation in the smaller airways of the lungs. The inflammation irritates the muscles around the airways and causes them to constrict. This causes your airways to narrow. It is then more difficult for air to get in and out of your lungs. This causes the typical symptoms of wheeze, chest tightness and shortness of breath. The inflammation also causes the lining of your airways to make extra mucus which causes coughing.
Asthma symptoms can flare up from time to time and there may be no apparent reason why. However, some people find that symptoms are made worse by triggers such as exercise and pollen. These things cause your body to produce chemical substances called leukotrienes, which cause the inflammation. Zafirlukast helps control the symptoms of asthma by blocking the effects of these leukotrienes.
Before taking zafirlukast
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking zafirlukast it is important that your doctor knows:
Si estás embarazada, intentando tener un bebé o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take zafirlukast
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about zafirlukast and will provide you with a full list of the side-effects which you could experience from taking it.
Take zafirlukast exactly as your doctor tells you to. The usual dose is one tablet in the morning and one in the evening.
Swallow the tablet with a drink of water. You should take it 'on an empty stomach', which means that you should take the tablet about an hour before a meal, or wait until two hours afterwards. This is because your body absorbs less zafirlukast after a meal, which means the medicine is less effective.
Take zafirlukast regularly every day, even if your asthma is well controlled. Try not to miss any of your doses but if you do forget, take it as soon as you remember. If when you remember, it is almost time to take your next dose then skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, your doctor may want you to have blood tests from time to time to check on the way your liver is working.
Zafirlukast will not give you immediate relief if you are having an asthma attack. Your doctor will prescribe a reliever inhaler for you to use if this happens. Make sure that you keep it with you all the time in case you need to use it.
Si notas que tus síntomas de asma están empeorando, o que necesitas usar el inhalador de alivio más regularmente de lo habitual, por favor contacta a tu médico o enfermera para obtener asesoramiento de inmediato.
No fume. Fumar causa irritación severa y daño a los pulmones. Empeorará su condición y reducirá los efectos beneficiosos de su medicación.
Si compras algún medicamento, consulta con un farmacéutico para asegurarte de que sea adecuado para ti. Algunos analgésicos antiinflamatorios y la aspirina pueden empeorar los síntomas del asma en algunas personas.
Can zafirlukast cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with zafirlukast. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common zafirlukast side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
High temperature (fever), sore throat and chest infections | Si es problemático, hable con su médico |
Common zafirlukast side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling sick (nausea) or being sick (vomiting), tummy (abdominal) pain | Stick to simple meals and drink plenty of water. Speak with your doctor if this continues |
Headache, muscle aches and pains | Ask your pharmacist to recommend a suitable painkiller if troublesome |
Importante: if you get any of the following symptoms, you should let your doctor know straightaway so that you can have a check-up:
Constantly feeling or being sick, stomach pain, yellowing of your skin or the whites of your eyes (jaundice) and feeling generally unwell. These can be signs of a problem with your liver.
Flu-like symptoms, tingling feelings or numbness in your arms or legs, difficulties with breathing, and skin rash. These can be a sign of a very rare but serious disorder called Churg-Strauss syndrome.
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, por favor hable con su médico o farmacéutico para obtener más consejos.
How to store zafirlukast
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tenido una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Si vas a someterte a una operación o a un tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can I take zafirlukast with other asthma medications?
The article mentions that zafirlukast will not provide immediate relief for asthma attacks and that a reliever inhaler will be prescribed for such situations. It also advises checking with your pharmacist about taking other medicines, including over-the-counter and herbal remedies, to ensure they are suitable with zafirlukast.
Does zafirlukast treat asthma or just its symptoms?
Zafirlukast works by blocking the effects of leukotrienes, which are chemical substances in the body that cause inflammation in the airways. By doing this, it helps to control the symptoms of asthma, such as wheezing, chest tightness, and shortness of breath.
How long will it take for zafirlukast to start working?
The article states that zafirlukast will not give immediate relief if you are having an asthma attack. It implies it is a regular, preventative medication rather than a fast-acting one, but does not specify a timeframe for when its regular symptom control effects will become noticeable.
What should I do if I accidentally take more than the prescribed dose of zafirlukast?
If you suspect that you or someone else might have had an overdose of zafirlukast, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Is zafirlukast safe to use during pregnancy or while breastfeeding?
Before starting zafirlukast treatment, it is important to inform your doctor if you are pregnant, trying for a baby, or breastfeeding. Your doctor will need to consider this information to determine if zafirlukast is suitable for you.
Lecturas adicionales y referencias
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 3 de septiembre de 2027
3 Sept 2024 | Última versión

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