Rimegepant for migraine headache
Vydura
Revisado por pares por Dr Krishna Vakharia, MRCGPAuthored by Michael Stewart, MRPharmSPublicado originalmente 19 Dic 2022
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This medicine can treat an active migraine attack and prevent future attacks from happening.
For treatment of a migraine attack once it has started, the recommended dose is one 75 mg tablet as needed and no more than once daily.
To prevent migraines the dose is one tablet every other day.
The maximum dose is one 75 mg tablet every day.
The most common side-effect is feeling sick (nausea), if this happens try taking your dose with a meal or snack.
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About rimegepant for migraine headache
Tipo de medicamento | CGRP-receptor blocker |
Usado para | Treating and preventing migraine headaches in adults aged 18 years or older |
También llamado | Vydura® |
Disponible como | 'Melt-in-the-mouth' orodispersible tablets |
Rimegepant can be used to treat an active dolor de cabeza por migraña or to prevent migraine attacks from happening. Although it is not known exactly how rimegepant works, it is known to block the action of a substance called calcitonin gene-related peptide (CGRP) by attaching to its receptor sites in the brain. People with migraine may have raised levels of CGRP. By blocking the effects of CGRP, rimegepant can stop an active migraine attack and also reduce the number of attacks over time.
In people with migraine, it is thought that some chemicals in the brain increase in activity. As a result, parts of the brain then send out confused signals which result in the symptoms of headache and sickness (náuseas y vómitos). Why people with migraine should develop these chemical changes is not clear, but for some people there may be things which trigger an attack, like certain foods or drinks.
Before taking rimegepant
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking rimegepant it is important that your doctor knows:
Si estás embarazada, intentando concebir o amamantando.
If you have any problems with the way your kidneys work or the way your liver works.
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
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How to take rimegepant tablets
Volver al contenidoBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer’s leaflet will give you more information about rimegepant and a full list of side-effects which you may experience from taking it.
Take rimegepant exactly as your doctor tells you to. If you are taking rimegepant to prevent migraine attacks then the usual dose is one 75 mg tablet every other day.
If you are taking rimegepant to treat a current migraine headache then you can take one tablet every day if required. The maximum dose is one 75 mg tablet per day.
The tablet is orodispersible which means it will dissolve in the mouth without the need to drink water.
Take care to handle the tablet as little as possible and make sure your hands are dry. Peel back the foil on the blister, do not try to push the tablet through the foil. Place the tablet on, or under, your tongue and allow it to dissolve.
It is not important whether you take your dose before or after food.
If you forget to take a dose, take it as soon as you remember unless your next dose is nearly due, in which case, leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed one.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIntenta mantener todas tus citas regulares con tu médico. Esto es para que tu médico pueda revisar tu progreso.
If you find that rimegepant does not relieve or prevent your migraines, make an appointment to discuss this with your doctor, as an alternative medicine may be more effective for you.
It may help to keep a migraine diary. Note down when and where each migraine attack started, what you were doing, and what you had eaten that day. A pattern may emerge and it may be possible for you to avoid some of the things that trigger your migraine attacks.
Some people may benefit from taking a non-steroidal anti-inflammatory painkiller (such as ibuprofen) in addition to rimegepant. Your doctor will advise you about this if it is recommended for you.
Some medicines can affect how well rimegepant works. Your doctor or pharmacist will advise you on this, and you will find a full list in the manufacturer's information supplied with your pack.
If you buy any medicines, check with your doctor or a pharmacist that they are suitable for you to take with rimegepant. You should not take the herbal medicine St John's wort while you are being treated with rimegepant..
Some people who get frequent migraine attacks are in fact getting medication-induced headache. Dolor de cabeza inducido por medicación (also called medication-overuse headache) is caused by taking painkillers too often. If you use painkillers on more than two days a week on a regular basis, you may be at risk of this. You should talk with your doctor if you suspect it.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking rimegepant.
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Can rimegepant cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rimegepant. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common rimegepant side-effects (affecting fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Sentirse mal (náuseas) | Stick to simple foods, avoid rich or spicy foods. Try taking your dose with a meal |
Stop using rimegepant and seek medical attention if you develop any signs of a severe reacción alérgica, such as shortness of breath, facial swelling or a severe skin rash.
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store rimegepant tablets
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Once the foil blister is opened do not store the tablet for later use.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

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Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
- Manufacturer's PIL, VYDURA® 75 mg oral lyophilisate; Pfizer Limited, The electronic Medicines Compendium. Dated September 2022.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 18 Jun 2027
19 Dic 2022 | Publicado originalmente
Escrito por:
Michael Stewart, MRPharmSRevisado por pares por
Dr Krishna Vakharia, MRCGP

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