Procyclidine
Kemadrin
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 24 Feb 2023
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Procyclidine is used to relieve unwanted side-effects caused by antipsychotic medicines. It may also be used in the early stages of Parkinson's disease.
It is usually prescribed as a three times daily dose, but you may be advised to take it more or less often than this. Take it exactly as your doctor tells you to.
The most common side-effects are a dry mouth, constipation, blurred vision and difficulties passing urine.
De un vistazo
Procyclidine is a medicine that helps with unwanted movements caused by some medicines and Parkinson's disease.
It can relieve symptoms like uncontrolled body movements, shakiness, and muscle stiffness.
Your doctor will advise you on the correct dosage, which may be increased gradually.
Common side effects include dry mouth, constipation, blurred vision, and dizziness.
Do not stop taking procyclidine suddenly if you have been on it for some time.
About procyclidine
Tipo de medicamento | Un medicamento antimuscarínico |
Usado para | Unwanted 'extrapyramidal side-effects' caused by some medicines, Parkinson's disease and Parkinsonism |
También llamado | Kemadrin® |
Disponible como | Tabletas, líquido oral e inyección |
Procyclidine is used to relieve unwanted side-effects caused by some antipsychotic medicines. Antipsychotic medicines are prescribed for mental health problems such as esquizofrenia. As a side-effect of treatment, antipsychotic medicines can sometimes cause unwanted body movements, some of which may be severe. These movement disorders are often referred to as 'extrapyramidal side-effects' or 'Parkinsonism' and include things like uncontrolled face and body movements, shakiness (tremor), and restlessness. Procyclidine is prescribed to relieve these types of symptoms.
Procyclidine is also used to relieve some of the symptoms of enfermedad de Parkinson, which include movement problems such as stiff muscles, shakiness (tremor) and eye movements, as well as sweating and producing too much saliva.
Before taking procyclidine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking procyclidine it is important that your doctor knows:
Si estás embarazada, intentando tener un bebé o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado o el funcionamiento de tus riñones.
If you have any problems with your heart or blood vessels.
If you have prostate problems, or if you have been experiencing difficulty passing urine.
If you have been constipated for more than a week or if you have been told you have an obstruction in your bowel.
If you have a condition which causes raised pressure in your eyes, such as glaucoma.
Si tienes presión arterial alta (hipertensión).
Si tienes una condición que causa debilidad muscular, llamada miastenia gravis.
If you have ever had a mental health problem called psychosis.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take procyclidine
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about procyclidine and a full list of the side-effects which you may experience from taking it.
Take procyclidine exactly as your doctor tells you to. When starting your treatment your doctor will give you a small dose (usually half a tablet or 5 ml liquid medicine three times daily), and then may gradually increase your dose.
Carefully follow the directions your doctor gives to you. Although procyclidine is usually prescribed as a three times daily dose, you may be advised to take it more or less often than this.
It is not important whether you take procyclidine before or after food, although some people find taking it with meals helps prevent feelings of sickness (nausea).
Try to take your doses of procyclidine at the same times of day, each day. This will help you to remember to take your doses regularly.
If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Intenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
If you buy any medicines, check with a pharmacist that they are safe to take with procyclidine. Some antihistamines and some strong painkillers can interfere with procyclidine and increase the risk of side-effects.
If you are having an operation or any dental treatment, tell the person carrying out the treatment that you are taking procyclidine.
If you have been taking procyclidine for some time, do not stop taking it without speaking with your doctor first. Stopping suddenly can cause problems so your doctor will want to reduce your dose gradually when this is necessary.
Can procyclidine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with procyclidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common procyclidine side-effects - these affect fewer than 1 in 10 people | ¿Qué puedo hacer si experimento esto? |
Boca seca | Intenta masticar chicle sin azúcar o chupar caramelos sin azúcar |
Estreñimiento | Intenta comer una dieta equilibrada y beber varios vasos de agua cada día |
Blurred vision, feeling dizzy | No conduzca ni utilice herramientas o máquinas hasta que se sienta mejor |
Difficulty passing urine | If this becomes troublesome, let your doctor know |
Less common procyclidine side-effects - these affect fewer than 1 in 100 people | ¿Qué puedo hacer si experimento esto? |
Sentirse mal (náuseas) o estar enfermo (vómitos) | Stick to simple foods - avoid rich or spicy meals. Try taking procyclidine after meals if you are not already doing so |
A fast heartbeat, skin rash, mood changes, and feeling anxious, confused or forgetful | Si alguno de estos se vuelve problemático, informe a su médico |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store procyclidine
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can procyclidine affect my ability to drive or operate machinery?
Yes, procyclidine can cause blurred vision and feelings of dizziness. If you experience these side-effects, you should not drive or use tools or machines until these symptoms have passed and you feel better.
What should I do if I forget to take a dose of procyclidine?
If you forget a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to compensate for a forgotten dose.
What should I do if I suspect an overdose of procyclidine?
If you suspect that you or someone else has taken too much procyclidine, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Who should not take procyclidine?
There are several conditions where procyclidine might not be suitable or requires extra care. These include if you are pregnant, breastfeeding, have kidney or liver problems, heart or blood vessel issues, prostate problems or difficulty passing urine, long-term constipation or bowel obstruction, glaucoma, high blood pressure, a muscle weakness condition called myasthenia gravis, or a history of psychosis. Your doctor needs to be aware of all these conditions.
Lecturas adicionales y referencias
- Manufacturer's PIL, Kemadrin® Tablets 5 mg; Aspen Pharma Trading Ltd, The electronic Medicines Compendium. Dated August 2015.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 23 de agosto de 2027
24 Feb 2023 | Última versión

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