Rifampicina para la infección
Rifadin, Rimactane
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 2 Feb 2025
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Rifampicin is an antibiotic which is prescribed to treat (or prevent) a variety of serious infections.
Take your doses about an hour before a meal, or wait until two hours afterwards.
Rifampicin can interfere with a number of other medicines - please let your doctor know which other medicines you are taking.
De un vistazo
Rifampicin is an antibiotic used to treat serious infections like tuberculosis (TB).
También se puede prescribir para prevenir infecciones si has estado en contacto con alguien infectado.
Tome rifampicina con el estómago vacío, aproximadamente una hora antes de una comida o dos horas después.
La rifampicina puede hacer que la orina y el sudor se vuelvan de color naranja o rojizo, lo cual es inofensivo.
It can reduce the effectiveness of some hormonal contraceptives.
Consulte a su médico si experimenta enfermedad inexplicable, piel/ojos amarillos, pérdida de peso o cansancio extremo.
About rifampicin
Tipo de medicamento | An antibiotic and antituberculosis medicine |
|---|---|
Usado para | The treatment or prevention of serious infections, including tuberculosis |
También llamado | Rifampin (in US); Rifadin®, Rimactane®; |
Disponible como | Capsules, tablets, oral liquid medicine and injection |
Rifampicin is an antibiotic which is prescribed to treat a variety of serious infections. It is frequently prescribed to treat tuberculosis (TB). When prescribed in this way, it is usually prescribed as just one of a number of medicines to treat the infection. Alternatively, rifampicin can be prescribed to protect you from getting a serious infection (including TB, meningitis, or Haemophilus influenzae) because you have been in close contact with someone who has the infection.
TB is a bacterial infection which is mostly found in the lungs but which can affect any part of your body. TB is treatable with a course of medicines which usually need to be taken for six months. As several medicines are given together to treat TB, there are some brands of rifampicin tablets which contain the medicine in combination with one or more other medicines used to treat TB. These combination brands help to reduce the total number of tablets that need to be taken each day, and are listed in the table above.
Before taking rifampicin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking rifampicin it is important that your doctor knows:
Si estás embarazada o amamantando.
If you have any problems with how your liver works, or any problems with the way your kidneys work.
If you have any yellowing of your skin or of the whites of your eyes (jaundice).
Si tienes un trastorno sanguíneo hereditario raro llamado porfiria.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take rifampicin
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rifampicin and will provide you with a full list of the side-effects which you could experience from taking it.
There are several ways rifampicin could be prescribed for you, depending upon the reason why you are taking it. Your doctor will tell you how much to take for each dose. It is very important that you take it exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said to you, but if you are still unsure what to do, ask your pharmacist to explain it to you again. As a guide:
You may be asked to take one dose a day. This is the standard treatment for TB.
You may be asked to take one dose three times a week while you are being supervised. This is called directly observed therapy (DOT) for TB.
You may be asked to take one dose several times a day. This is the treatment for serious infections such as brucellosis and Legionnaires' disease.
You may be asked to take two doses a day, for two days. This is to protect against meningitis.
You may be asked to take one dose every day for four days. This is to protect against Haemophilus influenzae.
You may be asked to take one dose once a month while you are being supervised. This is the standard dose for leprosy.
Try to take your doses at the same time of day each day, as this will help you to remember to take them regularly. You should take rifampicin 'on an empty stomach'. This means that you should take your doses about an hour before a meal, or wait until two hours afterwards. This is because your body absorbs less rifampicin if taken at the same time as food, which means it is less effective.
If you have been given rifampicin liquid medicine to give to your child, please read the directions carefully to make sure that you give the correct amount.
If you forget to take a dose, take one as soon as you remember. Try to take the correct number of doses each day but do not take two doses at the same time to make up for a missed dose.
You must complete the full course of treatment (unless your doctor tells you otherwise), or your infection may come back. If you are taking rifampicin for TB, a course of treatment usually lasts for around six months.
Obteniendo el máximo de tu tratamiento
It is important that you keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have some blood tests from time to time during the treatment to make sure that your blood and liver are working properly.
There are several different brands and strengths of tablets and capsules. Each time you collect a new supply of medicine from your pharmacy, please check to make sure it looks to be the same as you have had before. If you have any questions about what you have been given, ask your pharmacist for further advice.
Rifampicin can cause your urine and sweat to have an orange or reddish colour. This is completely harmless - it is nothing for you to worry about.
If you wear soft contact lenses, please be aware that rifampicin can cause your lenses to become discoloured or stained. You may want to discuss this with your doctor or optician. An alternative type of contact lens may be more suitable for you, or alternatively, you may be advised to wear glasses instead.
Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. The contraceptive effect of 'the pill', 'mini pill', contraceptive patches and vaginal rings is reduced by rifampicin and so these on their own are not suitable types of birth control while you are on rifampicin.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because rifampicin can interfere with a number of other medicines (including some painkillers) and stop them from working properly. Also, some medicines (such as antacids for indigestion) can stop rifampicin from working properly and must not be taken at the same time.
If for any reason you miss any doses, you should let your doctor know about this. If your treatment is interrupted for any length of time, your doctor may want to adjust your dose.
Rifampicin can stop the oral typhoid vaccine from working as it should. If you are due to have any vaccinations, please make sure that the person treating you knows that you are taking this medicine.
If you are due to have an operation or any dental treatment, please tell the person carrying out the treatment that you are taking an antibiotic called rifampicin.
Can rifampicin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rifampicin. You will find a full list in the manufacturer's information leaflet supplied with the medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common rifampicin side-effects | ¿Qué puedo hacer si experimento esto? |
Sentirse mal (náuseas) o estar enfermo (vómitos), malestar en el vientre (abdominal) | Consuma comidas simples o suaves (evite alimentos ricos y picantes) |
Diarrea | Drink plenty of water to replace any lost fluids. If the diarrhoea continues for longer than 24 hours, becomes severe, or contains blood, please let your doctor know de inmediato |
Dolor de cabeza | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor |
Flu-like symptoms (high temperature, chills), feeling short of breath, flushing, skin rashes, or itching, feeling tired or dizzy | Speak with your doctor for advice if you experience any of these |
Importante: a few people have developed problems with their liver whilst taking this medicine. Although your doctor will check for this, you should speak with your doctor as soon as possible if you have any unexplained sickness (nausea or vomiting), yellowing of skin or eyes (jaundice), loss of weight, or feel extremely tired.
Si experimenta cualquier otro síntoma que crea que puede deberse al medicamento, por favor hable con su médico o farmacéutico para obtener más consejos.
How to store rifampicin
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
¿Por qué es importante tomar rifampicina con el estómago vacío?
Tomar rifampicina con el estómago vacío significa que debes tomar tus dosis aproximadamente una hora antes de una comida, o dos horas después. Esto se debe a que los alimentos pueden reducir la cantidad de rifampicina que tu cuerpo absorbe, haciendo que el medicamento sea menos efectivo.
What should I do if I accidentally miss a dose of rifampicin?
Si olvida tomar una dosis, tómela tan pronto como lo recuerde. Intente tomar el número correcto de dosis cada día. Sin embargo, es importante no tomar dos dosis al mismo tiempo para compensar una dosis olvidada. Si omite varias dosis o su tratamiento se interrumpe por cualquier período de tiempo, debe informar a su médico, ya que puede necesitar ajustar su dosis.
¿Puede la rifampicina afectar las vacunas?
Sí, la rifampicina puede impedir que la vacuna oral contra la fiebre tifoidea funcione como debería. Si tiene previsto recibir alguna vacuna, es importante informar a la persona que lo está tratando que está tomando este medicamento.
¿Con qué rapidez suelen mejorar los efectos secundarios de la rifampicina?
Muchos de los efectos secundarios no deseados a menudo mejoran a medida que su cuerpo se adapta al nuevo medicamento. Sin embargo, si algún efecto secundario persiste o se vuelve problemático, debe consultar a su médico o farmacéutico para obtener asesoramiento.
¿Cuáles son los signos comunes de posibles problemas hepáticos que debo vigilar mientras tomo rifampicina?
Aunque su médico lo vigilará por problemas hepáticos, debe contactarlo lo antes posible si nota alguna enfermedad inexplicable (náuseas o vómitos), amarillamiento de su piel o ojos (ictericia), pérdida de peso inesperada, o si se siente extremadamente cansado.
Lecturas adicionales y referencias
- Manufacturer's PIL, Rifadin® 150 mg Capsules; Sanofi, The electronic Medicines Compendium. Dated May 2024.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 2 Feb 2028
2 Feb 2025 | Última versión

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