Tabletas de Clorambucilo
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 19 Dic 2022
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Chlorambucil is used to treat a number of different cancers of the blood or lymphatic system.
Mantén tus citas regulares con tu médico o hospital. Necesitarás realizarte análisis de sangre y chequeos frecuentes.
The most common side-effects are feeling sick (nausea), diarrhoea and mouth ulcers.
About chlorambucil
Tipo de medicamento | Un medicamento de quimioterapia alquilante |
Usado para | Treatment of cancer |
Disponible como | Tablet |
Chlorambucil is used to treat some cánceres, particularly cancer of white blood cells and cancers of the lymphatic system. It can be prescribed both for adults and for children.
In cancer, certain cells in the body grow and multiply too fast. Anti-cancer medicines (chemotherapy) like chlorambucil work by preventing the growth and division of cells, and this reduces the number of cancer cells your body makes. Chlorambucil can be used as a treatment on its own, or alongside other medicines to help treat your condition.
Before taking chlorambucil
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or, if appropriate, your child) start taking chlorambucil it is important that your doctor or pharmacist knows:
Si estás embarazada o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado.
If you have a kidney problem called nephrotic syndrome.
If you have ever had a fit (seizure) or if you have epilepsy.
Si tienes una infección o te sientes mal.
Si tienes un trastorno sanguíneo hereditario raro llamado porfiria.
Si está tomando o usando cualquier otro medicamento. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take chlorambucil
Before you start this treatment, read any printed information you have been given by your doctor and the leaflet from inside your pack of tablets. The leaflet will give you more information about chlorambucil and a full list of side-effects which you may experience from taking it.
Chlorambucil will be given to you by a specialist doctor who is experienced in treating your condition. Your doctor will calculate what dose is right for you and will tell you how many tablets to take each day - it is important that you take chlorambucil exactly as you have been told. Your dose will also be printed on the label of your pack. If you are unsure about what to do, or if you have any other concerns, you should contact your doctor or hospital clinic for advice.
You should take the tablets when your stomach is empty, which means taking them one hour before eating food, or waiting until three hours afterwards. This is because food prevents chlorambucil from being absorbed by your body, which means the medicine is much less effective for you.
Swallow the tablets with a drink of water. Do not break, crush or chew them.
Try to take chlorambucil at the same time each day, as this will help you to remember to take your doses.
If you are sick shortly after taking a dose, or if you forget a dose, contact your doctor or clinic for advice on what to do. You will be told whether to take the dose again, or to wait until the next dose is due.
Obteniendo el máximo de tu tratamiento
Debe intentar mantener sus citas regulares con su médico o hospital. Esto es para que su médico pueda verificar su progreso. Necesitará hacerse análisis de sangre y chequeos regulares durante su tratamiento.
Chlorambucil lowers the number of white cells in your blood, increasing the chance of you getting an infection. You should take certain precautions to reduce the risk of infection - if possible, avoid people with infections and let your doctor know if you think you are getting a sore throat or if you have a high temperature (fever).
It is important that you do not get pregnant or father a child while you are taking chlorambucil. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.
If you intend to have children in the future, you should ask your doctor for advice about family planning before you begin taking chlorambucil. There is a risk of reduced fertility after treatment with chlorambucil.
This medicine lowers your natural protection against infections. It is important to protect yourself from serious illness by having any vaccinations your doctor offers you. If you live with other people they can also help protect you by having their vaccinations when invited.
Algunas vacunas pueden no ser adecuadas para personas con sistemas inmunológicos debilitados. Siempre informe a la persona que le está vacunando que está tomando este medicamento.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Can chlorambucil cause problems?
Along with their useful effects, most medicines can cause side-effects although not everyone experiences them. Before you start treatment with chlorambucil, your doctor will discuss with you the possibility of unwanted side-effects occurring. The table below contains some of the most common ones associated with chlorambucil. You will find a full list of side-effects in the manufacturer's information leaflet supplied with your tablets.
Común chlorambucil side-effects - these affect fewer than 1 in 10 people who take this medicine | ¿Qué puedo hacer si experimento esto? |
Sentirse mal (náuseas) o estar enfermo (vómitos) | Consuma alimentos simples. Informe a su médico sobre esto, ya que un medicamento contra las náuseas puede ayudar |
Diarrea | Bebe mucha agua para reponer los líquidos perdidos. Si esto continúa, consulta a tu médico |
Úlceras bucales | Cepillarse los dientes 2-3 veces al día con un cepillo de dientes suave y usar enjuague bucal regularmente puede ayudar a prevenir esto. Si las úlceras bucales se convierten en un problema, consulte a su médico |
Less common but more serious chlorambucil side-effects | ¿Qué puedo hacer si experimento esto? |
Unexpected bruising or bleeding, a high temperature (fever), or symptoms of an infection | Informa a tu médico sobre esto de inmediato |
Erupción cutánea | Let your doctor know about this as soon as possible. Some skin rashes can be a sign of an allergic-type reaction |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store chlorambucil
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Store the tablets in a refrigerator.
Return any unused or unwanted tablets to your pharmacy to destroy. These will need special disposal.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, donde se encargarán de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.
Preguntas frecuentes
What should I do if I accidentally miss a dose of chlorambucil?
If you miss a dose of chlorambucil, or if you are sick shortly after taking a dose, you should contact your doctor or clinic for advice. They will tell you whether to take the dose again or to wait for your next scheduled dose.
How do I care for my mouth if I develop mouth ulcers while taking chlorambucil?
If you experience mouth ulcers, brushing your teeth 2-3 times a day with a soft toothbrush and using a mouth rinse regularly can help. If the mouth ulcers become bothersome or do not improve, you should speak with your doctor for further advice.
Are there any specific foods or drinks I should avoid while on chlorambucil treatment?
The article states that food prevents chlorambucil from being absorbed properly, making the medicine less effective. Therefore, you should take the tablets on an empty stomach: one hour before eating or three hours after eating. There are no other specific food or drink restrictions mentioned beyond this advice for absorption.
Can I receive vaccinations while I am being treated with chlorambucil?
You should discuss any vaccinations with your doctor, as some may not be suitable for people with lowered immune systems due to chlorambucil. It is important to inform the person giving the vaccination that you are taking this medicine.
What is the proper way to dispose of any leftover or expired chlorambucil tablets?
Any unused or unwanted chlorambucil tablets should be returned to your local pharmacy for proper disposal. This is important as they require special handling.
Lecturas adicionales y referencias
- Manufacturer's PIL, Chlorambucil 2 mg tablets; Aspen Pharma Trading Ltd, The electronic Medicines Compendium. Dated January 2017.
- Medicamentos Completo BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
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