Enzalutamida para el cáncer de próstata
Xtandi
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 18 May 2024
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Take four tablets together, once a day.
Swallow the tablets whole with a drink of water.
At a glance
Enzalutamide is an anti-androgen medicine used to treat advanced prostate cancer.
It works by blocking male hormones like testosterone that prostate cancer cells need to grow.
Take 4 tablets once daily, at the same time each day, with water.
You can take enzalutamide with or without food.
Common side-effects include feeling tired, hot flushes, and high blood pressure.
Tell your doctor if you have had seizures, heart problems, or kidney/liver issues before taking.
Enzalutamide can harm an unborn child, so use effective birth control if having sex with a woman who could become pregnant.
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About enzalutamide
Tipo de medicamento | An anti-androgen medicine |
Usado para | Advanced prostate cancer |
También llamado | Xtandi® |
Disponible como | Comprimidos |
In some men with prostate cancer, the cancer cells spread to parts of the body other than the prostate gland. When this happens, it is referred to as late, advanced or metastatic prostate cancer. Treatment options for this type of cancer typically include hormone treatment, surgery, radiotherapy and chemotherapy.
Enzalutamide is a hormone treatment - it belongs to a group of medicines known as anti-androgens. It works by blocking the action of male hormones called androgens. Testosterone is an androgen. Prostate cancer cells need the male hormone testosterone to grow and multiply well. By blocking the action of androgens such as testosterone, enzalutamide slows the growth of the cancer cells.
Before taking enzalutamide
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking enzalutamide it is important that your doctor knows:
If you have ever had a fit (seizure) or if you have been told you may be at risk of having a seizure.
If you have heart or blood vessel problems.
If you have any problems with the way your kidneys work or any problems with the way your liver works.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to take enzalutamide
Volver al contenidoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about enzalutamide and will provide you with a full list of the side-effects which you may experience from taking it.
Take enzalutamide exactly as your doctor tells you to. The usual dose is four 40 mg tablets taken together, once a day. Your dose will be printed on the label of the pack to remind you about what the doctor said to you.
Take the tablets with a drink of water. Swallow the tablets whole - do not break or chew the tablets.
You can take your doses either before or after food, but try to take enzalutamide at the same time of day each day. This will help you to remember to take your doses regularly.
If you do forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the forgotten dose. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIntenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable for you to take with your other medicines.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking enzalutamide.
Enzalutamide may harm an unborn child. This means that if you are having sex with a woman who could become pregnant, you must use a condom along with another effective birth control method. If you are having sex with a woman who is already pregnant, you must use a condom to protect the unborn child.
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Can enzalutamide cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with enzalutamide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if you experience any symptoms which you think may be due to enzalutamide.
Very common enzalutamide side-effects (these affect more than 1 in 10 men) | ¿Qué puedo hacer si experimento esto? |
Feeling tired or weak | Take a rest when needed. Do not use tools or machines while affected. Take care moving about as this medicine can put you at risk of falls. |
Feeling hot and flushed | Try to keep as cool as possible by wearing light and airy clothes |
Presión arterial alta | Your doctor will be monitoring your progress and will check for this |
Common enzalutamide side-effects (these affect fewer than 1 in 10 men) | ¿Qué puedo hacer si experimento esto? |
Feeling anxious, memory problems, itching, dry skin, falls, breast enlargement, an urge to move your legs, an altered sense of taste | Speak with your doctor for advice |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico para obtener más consejos.
How to store enzalutamide
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What specifically is advanced prostate cancer and how does enzalutamide fit into its treatment?
Advanced prostate cancer means that the cancer cells have spread from the prostate gland to other parts of the body. Enzalutamide is a hormone treatment, specifically an anti-androgen, used for this type of cancer. It works by blocking male hormones like testosterone that prostate cancer cells need to grow, thereby slowing the cancer's progression.
Are there any specific medical conditions that might prevent me from taking enzalutamide?
Yes, there are some conditions your doctor needs to know about. These include if you have ever had a seizure or are at risk of one, if you have heart or blood vessel problems, or any issues with your kidneys or liver function. It's also important to tell your doctor about any allergies you have.
What should I do if I accidentally miss a dose of enzalutamide?
If you forget to take a dose, you should take it as soon as you remember. However, if you don't remember until the following day, you should skip the forgotten dose. It's important not to take two doses together to try and make up for a missed one.
What precautions should I take regarding contraception while on enzalutamide, even if my partner is pregnant?
Enzalutamide can harm an unborn child. If you are having sex with a woman who could become pregnant, you must use a condom along with another effective birth control method. If you are having sex with a woman who is already pregnant, you must still use a condom to protect the unborn child.
What are the common side effects of enzalutamide, and what should I do about them?
Very common side effects include feeling tired or weak, feeling hot and flushed, and high blood pressure. For tiredness, rest when needed and be careful moving around as it can increase the risk of falls. For hot flushes, try to stay cool by wearing light clothing. Your doctor will monitor your blood pressure. Less common side effects include anxiety, memory problems, itching, dry skin, breast enlargement, an urge to move your legs, an altered sense of taste, and headaches. For these, speak with your doctor for advice or, for headaches, drink water and ask your pharmacist about a painkiller.
How should I store enzalutamide tablets to ensure they remain effective and safe?
You should keep the tablets out of the reach and sight of children. Store them in a cool, dry place, away from direct heat and light.
What should I do if I think I've taken too much enzalutamide, or if I have old medication?
Never take more than your prescribed dose. If you suspect an overdose, you should go to the accident and emergency department of your local hospital immediately and take the medicine container with you. You should also not keep out-of-date or unwanted medicines; take them to your local pharmacy for safe disposal.
Lecturas adicionales y referencias
- Manufacturer's PIL, Xtandi® 40 mg and 80 mg film-coated tablets; Astellas Pharma Ltd, The electronic Medicines Compendium. Dated April 2024.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 24 Abr 2027
18 May 2024 | Última versión

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