Adefovir para la hepatitis B
Hepsera
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 27 Oct 2022
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Adefovir is an antiviral medicine. You have been prescribed it for chronic hepatitis B infection.
The usual dose is one 10 mg tablet daily. You can take your doses either with or without food.
It is important to take adefovir regularly every day, preferably at the same time each day.
De un vistazo
Adefovir is an antiviral medicine used to treat chronic hepatitis B infection in adults.
It works by stopping the hepatitis B virus from multiplying in the body.
You usually take one tablet daily, with or without food.
Treatment typically continues for several years, or it can be lifelong.
Adefovir does not stop you from passing the infection to others.
Let your doctor know immediately if you develop symptoms of lactic acidosis like feeling sick or dizzy.
About adefovir
Tipo de medicamento | Un medicamento antiviral |
Usado para | Chronic hepatitis B infection in adults |
También llamado | Adefovir dipivoxil; Hepsera® |
Disponible como | Comprimidos |
Hepatitis means inflammation of the liver. Some viruses can cause hepatitis. Hepatitis B is a virus which is carried in your bloodstream to your liver, where it can affect and damage your liver. Following infection with hepatitis B, a few people develop a persistent infection called chronic hepatitis B.
People with chronic hepatitis B usually need treatment to stop or to reduce the activity of the virus. This limits damage to the liver, which is a complication of the infection. One of the types of treatment currently given is an antiviral medicine. Antiviral medicines like adefovir work by stopping the hepatitis B virus from multiplying (replicating); this reduces the amount of the virus in your body.
A doctor who is a liver specialist will usually start the treatment for you. Treatment for chronic hepatitis B usually continues for several years, but can be lifelong. It can include more than one antiviral medicine.
Before taking adefovir
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking adefovir it is important that your doctor knows:
Si estás embarazada, intentando concebir o amamantando.
Si tienes un problema con el funcionamiento de tus riñones.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take adefovir
Before you start the treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about adefovir, and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take adefovir exactly as your doctor tells you to. The usual dose is one 10 mg tablet daily. You can take the tablet either with or without food.
Try to take your doses at the same time of day each day, as this will help you to remember to take adefovir regularly.
If you are ever sick within one hour of taking a tablet, you should take a second tablet. This is because your body will not have absorbed a sufficient amount of the medicine. If, however, you are sick and it is more than one hour after taking a tablet, you do not need to take a second dose, as your body will have already absorbed the full dose.
If you forget to take a dose at your usual time, take it as soon as you remember. However, if you do not remember until the following day, leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Keep your regular appointments with your doctor. This is so that your progress can be monitored. You will need to have some blood tests from time to time.
It is important that you continue to take adefovir regularly. Treatment for hepatitis B can be long-term. Continue to take the tablets, even if you feel well. This is to keep your liver healthy.
Treatment with adefovir does not stop you from passing the infection on to others through sexual contact, sharing needles to inject drugs, or from mother to baby. A vaccine is available which protects against hepatitis B and can be offered to your sexual and household contacts who are at risk of being infected. Do not have sex with anyone (especially any sex without using a condom) until they have been fully immunised and have had their blood checked to see that the immunisation has worked.
Most people with chronic hepatitis B will be advised to eat a normal healthy balanced diet. However, it is likely you will be advised not to drink alcohol. Alcohol will increase the risk and speed of you developing liver damage.
Medicines similar to adefovir have been associated with a serious side-effect in a few people. This is known as lactic acidosis. It is a problem where there is too much lactic acid in the blood. The symptoms associated with it are listed in the next section 'Can adefovir cause problems?'. Although this has occurred in only a very few people, you must let your doctor know de inmediato if you develop the symptoms listed below.
You must avoid getting pregnant while you are taking adefovir. Make sure you have discussed with your doctor which types of contraception are suitable for you.
If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with adefovir and your other medicines.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Can adefovir cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with adefovir. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common adefovir side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling tired or weak | Do not drive and do not use tools or machines while affected. If this continues, speak with your doctor |
Cambios en algunos análisis de sangre | Su médico verificará estos |
Common adefovir side-effects (estos afectan a menos de 1 de cada 10 personas) | ¿Qué puedo hacer si experimento esto? |
Feeling sick (nausea) or being sick (vomiting), indigestion, wind, tummy (abdominal) pain | Mantente con comidas simples - evita alimentos grasos o picantes. Si persiste, consulta a tu médico |
Diarrea | Bebe mucha agua para reponer los líquidos perdidos |
Dolor de cabeza | Bebe mucha agua y pide a un farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Erupción cutánea con picazón | Si es problemático, hable con su médico |
Your doctor will discuss with you the possibility of this medicine causing a problem called acidosis láctica. Let your doctor know straightaway if you develop the following symptoms:
Feeling sick (nausea) or being sick (vomiting), tummy pain, loss of appetite, loss of weight, feeling weak or dizzy, and fast or gasping breathing.
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, hable con su médico o farmacéutico para obtener más consejos.
How to store adefovir
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can I take adefovir if I am already taking other medications for other health conditions?
It is important that your doctor knows about all other medicines you are taking, including any available without a prescription, as well as herbal and complementary medicines. This allows your doctor to assess if they are suitable to take with adefovir.
What should I do if I accidentally miss a dose of adefovir?
If you forget to take a dose, take it as soon as you remember. However, if you don't remember until the following day, you should skip the missed dose. Do not take two doses at once to make up for a forgotten dose.
What is lactic acidosis, and how can I recognise its symptoms?
Lactic acidosis is a serious condition where there is too much lactic acid in your blood. Symptoms to watch out for include feeling sick (nausea) or being sick (vomiting), tummy pain, loss of appetite, weight loss, feeling weak or dizzy, and fast or gasping breathing. You must contact your doctor straight away if you develop any of these symptoms.
Does adefovir cure chronic hepatitis B?
Adefovir works by stopping the hepatitis B virus from multiplying, which reduces the amount of the virus in your body and limits damage to the liver. Treatment for chronic hepatitis B usually continues for several years, and can be lifelong, to keep your liver healthy.
Can I stop taking adefovir if I start feeling better?
It is important to continue taking adefovir regularly, even if you feel well. Treatment for hepatitis B can be long-term, and continuing your medication as prescribed is crucial for maintaining your liver health.
Lecturas adicionales y referencias
- Manufacturer's PIL, Hepsera® 10 mg tablets; Gilead Sciences Ltd, Medicines.ie. Irish Pharmaceutical Healthcare Association. Dated April 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Helen Allen, MPharm
Farmacéutico, Autor Médico
MPharm
Helen Allen se graduó como farmacéutica en 1979 y pasó 3 años como autora de los folletos de información sobre medicamentos para EMIS.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 25 Mar 2027
27 Oct 2022 | Última versión
29 May 2013 | Publicado originalmente
Escrito por:
Helen Allen, MPharm

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