Can I take Simvastatin and Venlafaxine krka together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together may slightly increase the level of simvastatin in your blood. This can increase the risk of side effects, particularly muscle pain or weakness.
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Why this happens
Both medicines are processed by the same enzyme in the liver (CYP34A). Because they are 'competing' for the same enzyme, the body may break down simvastatin more slowly than usual.
What you should do
You can usually take these together, but you should be vigilant. Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. Your doctor may choose to monitor your liver function or adjust your dose if you experience side effects.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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