Selegilina para la enfermedad de Parkinson
Eldepryl
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 7 Ago 2023
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The usual dose is one tablet daily.
Keep your regular appointments with your doctor so your progress can be monitored.
As your symptoms improve and your body movements become easier, be careful not to overdo physical activities.
Do not stop taking this medicine without speaking with your doctor first - stopping suddenly can cause problems.
De un vistazo
Selegiline is a medicine used to treat Parkinson's disease.
It works by increasing the effect of dopamine in the brain, helping to ease symptoms like tremor and stiffness.
You can take one tablet a day, usually in the morning, with or without food.
Do not stop taking selegiline suddenly without discussing it with your doctor.
Common side-effects include feeling sick, headaches, and feeling light-headed.
Always check with your doctor or pharmacist before taking other medicines with selegiline.
About selegiline
Tipo de medicamento | A monoamine-oxidase-B inhibitor |
Usado para | enfermedad de Parkinson |
También llamado | Eldepryl® |
Disponible como | Comprimidos |
The symptoms of enfermedad de Parkinson - tremor, stiffness and slow movement - are due to there being less of a chemical called dopamine in your brain. Selegiline works by increasing the effect of dopamine in the brain, and this helps to ease these typical symptoms.
You may be prescribed selegiline as a treatment on its own, or alongside other medicines for Parkinson's disease which contain a medicine called levodopa. When it is prescribed with other medicines, selegiline helps to prevent some of the problems which can occur with these other treatments. These problems may be referred to as 'end-of-dose' fluctuations, or 'on-off' symptoms.
Before taking selegiline
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking selegiline it is important that your doctor or pharmacist knows:
Si estás embarazada o amamantando.
If you have a stomach or duodenal ulcer.
If you have high blood pressure, an irregular heartbeat, or angina pain.
If you have had a mental health problem (in particular, psychosis).
If you have a problem with the way your liver works, or with the way your kidneys work.
Si tienes un trastorno sanguíneo hereditario raro llamado porfiria.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take selegiline
Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about selegiline and will provide you with a full list of the side-effects which you may experience from taking it.
Take selegiline exactly as your doctor tells you to. The usual dose is one tablet a day, in the morning. When you first start taking it your doctor is likely to suggest you start on the lower-strength (5 mg) tablet. You may then be prescribed the higher-strength (10 mg) tablet after a couple of weeks. You can take selegiline 5 mg and 10 mg tablets before or after food.
Si olvida tomar una dosis, tómela tan pronto como lo recuerde. Si no lo recuerda hasta el día siguiente, omita la dosis olvidada. No tome dos dosis juntas para compensar una dosis olvidada.
Obteniendo el máximo de tu tratamiento
Intenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
As your condition improves and your body movements become easier, be careful not to overdo physical activities. You should increase your activity gradually to allow your body to adjust to any changes in balance, circulation and co-ordination.
If you drink alcohol, ask your doctor for advice. Your doctor may recommend that you do not drink alcohol while you are on this medicine.
If you buy any medicines, check with a pharmacist that they are safe to take alongside this medicine. Selegiline should not be taken with strong painkillers and medicines containing sympathomimetics (present in some remedies for coughs and colds, and in decongestant nasal sprays and tablets).
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking selegiline.
Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary. Do not stop taking the medicine without speaking with your doctor first.
Can selegiline cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with selegiline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Muy común selegiline side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Boca dolorida | Informe a su médico sobre esto |
Común selegiline side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Sensación de malestar (náuseas), malestar estomacal | Stick to simple foods - avoid rich or spicy meals. Drink plenty of water |
Dolor de cabeza, otros dolores y molestias | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores continúan, informa a tu médico |
Feeling light-headed when getting up from a sitting or lying position | Getting up and moving more slowly should help. If this continues, speak with your doctor |
Feeling tired, shaky or dizzy | No conduzca ni utilice herramientas o máquinas hasta que se sienta mejor |
Uncontrolled muscle movements | Informe a su médico sobre esto |
Sleeping problems, feeling confused or depressed, hallucinations, blocked nose, sore throat, sweating | Si alguno de estos se vuelve problemático, hable con su médico |
Importante: On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:
Músculos rígidos o movimientos 'bruscos'.
Latidos del corazón inusualmente rápidos.
High temperature (fever), feeling sick (nausea) or being sick (vomiting), diarrhoea.
Sentirse delirante o ver visiones (alucinar).
Si experimenta otros síntomas que cree que pueden deberse al medicamento, hable con su médico o farmacéutico para obtener más consejos.
How to store selegiline
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can I take selegiline if I have an ulcer or heart condition?
It's important to inform your doctor or pharmacist if you have a stomach or duodenal ulcer, high blood pressure, an irregular heartbeat, or angina pain before starting selegiline. They will need to know about these conditions to ensure the medicine is suitable for you.
What should I do if I forget to take my selegiline tablet?
If you miss a dose, take it as soon as you remember. However, if you don't remember until the next day, you should skip the missed dose. Do not take two doses together to try and catch up for a forgotten dose.
Are there any specific activities I should be careful about when starting selegiline?
As your condition improves and your body movements become easier, be cautious not to overdo physical activities. It's recommended to increase your activity gradually to allow your body to adjust to any changes in balance, circulation, and coordination.
Can I take other medicines with selegiline, especially over-the-counter ones?
If you are buying any medicines, including those available without a prescription, or herbal remedies, always check with a pharmacist to make sure they are safe to take with selegiline. Selegiline should specifically not be taken with strong painkillers or medicines containing sympathomimetics, which are found in some cough and cold remedies, and decongestant nasal sprays and tablets.
What should I do if I need to stop taking selegiline?
Stopping this treatment suddenly can cause problems. If it becomes necessary to stop, your doctor will likely want you to reduce your dose gradually. Always speak with your doctor before you stop taking the medicine.
What are the common side effects of selegiline and what should I do about them?
Some common side effects include a sore mouth, feeling sick, stomach upset, headache, other aches and pains, feeling light-headed when standing up, feeling tired, shaky, or dizzy, and uncontrolled muscle movements. Many unwanted effects often improve as your body adjusts. For specific issues like feeling sick or headache, sticking to simple foods, drinking plenty of water, or asking your pharmacist for a suitable painkiller can help. If any side effects continue or become troublesome, or for more serious ones like uncontrolled muscle movements, feeling confused, sleeping problems, or hallucinations, you should speak with your doctor or pharmacist.
Lecturas adicionales y referencias
- Manufacturer's PIL, Eldepryl® Tablets, Orion Pharma (UK) Limited, The electronic Medicines Compendium. Dated March 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 6 de agosto de 2026
7 Ago 2023 | Última versión

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