Orphenadrine
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 7 Ago 2023
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Orphenadrine is usually prescribed to relieve unwanted side-effects caused by certain other medicines.
When starting your treatment your doctor may give you a low dose and gradually increase it over a few days. This helps your body adjust to the medicine and reduces the risk of side-effects. Take it exactly as your doctor tells you to.
The most common side-effects are a dry mouth, blurred vision, and feeling sick (nausea).
At a glance
Orphenadrine is an antimuscarinic medicine.
It treats movement disorders caused by some other medicines, like antipsychotics.
It can also relieve muscle stiffness in Parkinson's disease.
Take orphenadrine exactly as your doctor tells you, three times a day.
Do not stop taking orphenadrine suddenly without speaking to your doctor.
Common side-effects include dry mouth, sickness, blurred vision, and dizziness.
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About orphenadrine
Tipo de medicamento | Un medicamento antimuscarínico |
Usado para | Unwanted 'extrapyramidal side-effects' caused by some medicines |
Disponible como | Tabletas y medicina líquida oral |
Orphenadrine is an antimuscarinic medicine. It is prescribed for people who have unwanted movement disorders as a side-effect of taking certain other medicines, such as some antipsychotic medicines. These movement disorders are often referred to as 'extrapyramidal side-effects' and include things like uncontrolled face and body movements, tremor, and restlessness.
Orphenadrine can also be given to relieve muscle stiffness in people with enfermedad de Parkinson, although other medicines are generally preferred.
Before taking orphenadrine
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking orphenadrine it is important that your doctor knows:
Si estás embarazada o amamantando.
If you have any problems with the way your liver works, or the way your kidneys work.
If you have any problems with your heart or blood vessels.
If you have prostate problems, or if you have been experiencing difficulty passing urine.
If you have been constipated for more than a week.
If you have a condition which causes raised pressure in your eyes, such as glaucoma.
Si tienes presión arterial alta.
Si tienes una condición que causa debilidad muscular, llamada miastenia gravis.
If you have ever had a mental health problem called psychosis.
Si tienes un trastorno sanguíneo hereditario raro llamado porfiria.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to take orphenadrine
Volver al contenidoBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about orphenadrine and will provide you with a full list of the side-effects which you may experience from taking it.
Take orphenadrine exactly as your doctor tells you to. When starting this treatment your doctor may give you a low dose and gradually increase it every 2-3 days until your symptoms improve. Carefully follow the directions your doctor gives to you. Once you are on a full dose, it is likely that you will be taking three doses of orphenadrine a day, although it may be more or less often than this.
You can take orphenadrine before or after your meals. Try to take your doses at the same times of day each day, as this will help you to remember to take your doses regularly.
If you forget to take a dose, take it as soon as you remember unless your next dose is due. If it is nearly time for your next dose then take the next dose when it is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIntenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
If you buy any medicines, check with a pharmacist that they are safe to take with orphenadrine. Some antihistamines and some strong painkillers can interfere with orphenadrine and increase the risk of side-effects.
If you are having an operation or any dental treatment, tell the person carrying out the treatment that you are taking orphenadrine.
If you have been taking orphenadrine for some time, do not stop taking it without speaking with your doctor first. Stopping suddenly can cause problems so your doctor will want to reduce your dose gradually if this becomes necessary.
Ask your doctor for advice before drinking alcohol while you are on orphenadrine. Your doctor may recommend that you do not drink alcohol because it increases the possibility of side-effects such as feeling sleepy.
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Can orphenadrine cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with orphenadrine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Común orphenadrine side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Boca seca | Try chewing sugar-free gum or sucking sugar-free sweets. If this becomes troublesome, speak with your doctor |
Sentirse mal (náuseas) o estar enfermo (vómitos) | Mantente en alimentos simples - evita comidas ricas o picantes |
Blurred vision, feeling dizzy or restless | Si esto sucede, no conduzcas y no uses herramientas ni máquinas |
Si experimenta otros síntomas que cree que pueden deberse al medicamento, hable con su médico o farmacéutico para obtener más consejos.
How to store orphenadrine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What kind of symptoms are 'extrapyramidal side-effects' that orphenadrine helps with?
Extrapyramidal side-effects are movement disorders that can be caused by certain medicines, like some antipsychotics. They include things like involuntary movements of the face and body, shaking (tremor), and feeling restless.
Can orphenadrine be used for Parkinson's disease?
Yes, orphenadrine can be used to help relieve muscle stiffness in people with Parkinson's disease. However, the article notes that other medicines are generally preferred for this condition.
Are there certain medical conditions that might prevent me from taking orphenadrine?
Yes, there are several conditions your doctor needs to be aware of before you start taking orphenadrine. These include problems with your liver or kidneys, heart or blood vessel issues, prostate problems, difficulty passing urine, long-term constipation, certain types of glaucoma, high blood pressure, myasthenia gravis (muscle weakness), a history of psychosis, or a rare blood disorder called porphyria. Your doctor will assess if the medicine is suitable for you.
I'm on other medications. Do I need to tell my doctor before starting orphenadrine?
Yes, it is very important to tell your doctor about all other medicines you are taking. This includes any you've bought without a prescription, as well as herbal and complementary medicines, as some can interfere with orphenadrine.
How should I store orphenadrine at home?
You should keep all orphenadrine medicine out of reach and sight of children. Store it in a cool, dry place, away from direct heat and light.
What should I do if I accidentally take too much orphenadrine?
If you suspect that you or someone else might have taken an overdose of orphenadrine, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Can I share my orphenadrine with someone else if they have similar symptoms?
No, you should never give your orphenadrine to other people, even if their condition seems to be the same as yours. This medicine is prescribed specifically for you.
Lecturas adicionales y referencias
- Manufacturer's PIL, Orphenadrine Hydrochloride 50 mg/5 ml Oral Solution; Rosemont Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 6 de agosto de 2026
7 Ago 2023 | Última versión

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