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Inyección de paliperidona de acción prolongada

Xeplion, Trevicta, Byannli

Paliperidone long-acting injection will be given to you by your doctor or nurse every four weeks to begin with.

If you miss an appointment for an injection, please make another appointment as soon as possible.

The most common side-effects are headache and difficulties sleeping.

De un vistazo

  • Paliperidone is an antipsychotic medicine given as a long-acting injection.

  • It is used for adults with schizophrenia to help regulate brain chemicals and control symptoms.

  • Injections are given regularly, typically once a month, with 3-monthly and 6-monthly options available.

  • Benefits include not having to remember to take daily tablets.

  • Keep all regular appointments for your injections and monitoring.

  • Tell your doctor if you are pregnant, have a heart condition, or other specified health issues.

  • Do not drink alcohol while on paliperidone as it increases the risk of side-effects.

About paliperidone long-acting injection

Tipo de medicamento

Un medicamento antipsicótico

Usado para

Schizophrenia in adults

También llamado

Xeplion®; Trevicta®; Byannli®

Disponible como

Long-acting intramuscular depot injection

Esquizofrenia is a mental health condition that causes disordered ideas, beliefs and experiences. You will have been prescribed paliperidone to relieve the symptoms of schizophrenia. Such symptoms include hearing, seeing, or sensing things that are not real, having mistaken beliefs and feeling unusually suspicious. Paliperidone works on the balance of chemical substances in your brain to help control these types of symptoms.

Long-acting or 'depot' injections are used for maintenance once your symptoms have been eased by taking tablets. The injection slowly releases paliperidone into your body. You will need to receive the injection regularly, once every month. A three-monthly injection (Trevicta®) is available for people who are stable on once-monthly injections. There is also a six-monthly injection (Byannli®). The main advantage of a depot injection is that you do not have to remember to take tablets every day.

Before having paliperidone injection

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having paliperidone injections, it is important that your doctor knows:

  • Si estás embarazada o amamantando.

  • Si tienes una afección cardíaca o enfermedad de los vasos sanguíneos.

  • Si tienes problemas de hígado, riñón o próstata.

  • Si tienes algún problema con tu respiración.

  • If you have any of the following: epilepsy, depresión, enfermedad de Parkinson, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called miastenia gravis.

  • If you have ever had yellowing of your skin or the whites of your eyes (ictericia) o un trastorno sanguíneo.

  • If you are scheduled to have eye cataract surgery.

  • If you have a tumour on your adrenal gland (a condition called phaeochromocytoma), or if you have been told you have 'a prolactin-dependent tumour'.

  • Si ha tenido una reacción alérgica a un medicamento.

  • Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.

How paliperidone long-acting injection is given

  • Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about paliperidone and it will also provide you with a full list of the side-effects which you may experience from having it.

  • Paliperidone injection will be given to you by your doctor or nurse. The first two doses will be injected into a muscle in your upper arm. After this, the injections can either be given into a muscle in your arm, or if preferred, the buttocks.

  • If you haven't received paliperidone injection before, you will initially be given a dose of 150 mg and then a dose of 100 mg a week later. From then on, you will need to have one injection each month. Your doctor will adjust the amount of paliperidone given to suit what is right for you.

  • When your dose of once-monthly injection is stabilised, a three-monthly injection is available and may be suitable for you.

Obteniendo el máximo de tu tratamiento

  • Your treatment will require careful monitoring to make sure that you get the best possible benefit from paliperidone. Keep your regular doctor's appointments so that you get your injections on time and your progress can be checked. If you miss an appointment for an injection, contact your doctor to arrange for another appointment as soon as possible. This is so that you can be given the injection without any further delay.

  • If you are due to have any dental treatment or an operation, please tell the person carrying out the treatment that you have had a paliperidone injection. This is important because it may interfere with any anaesthetic you receive. If you are having cataract surgery, it is particularly important that you tell your surgeon that you are on paliperidone. This is because an eye problem known as 'floppy iris syndrome' has developed in some people and your doctor will want to advise you about the risks of this.

  • If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with paliperidone.

  • If you have diabetes you may need to check your blood glucose more frequently, as paliperidone may affect the levels of sugar in your blood. Your doctor will advise you about this.

  • If you drink alcohol, please ask your doctor for advice. Alcohol increases the risk of side-effects from paliperidone, so it is best avoided.

Can paliperidone cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with paliperidone long-acting injection. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common paliperidone injection side-effects (these affect more than 1 in 10 people)

¿Qué puedo hacer si experimento esto?

Difficulties sleeping

Discuss this with your doctor if it becomes troublesome

Dolor de cabeza

Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico

Common paliperidone injection side-effects (these affect fewer than 1 in 10 people)

¿Qué puedo hacer si experimento esto?

Pain at the site of the injection

This should quickly pass. If the area becomes red, swollen or 'lumpy', let your doctor know

Sintiéndose mareado, cansado o somnoliento

Do not drive and do not use tools or machines. Do not drink alcohol

Feeling shaky or restless, unusual or uncontrollable movements

Speak with your doctor

Feeling sick (nausea) or being sick (vomiting), indigestion, tummy (abdominal) discomfort

Mantente en comidas simples - evita alimentos ricos o picantes

Diarrea

Bebe mucha agua para reponer los líquidos perdidos

Estreñimiento

Drink plenty of water and eat a well-balanced diet

Increased infections, weight increase or loss, mood changes, high blood pressure, toothache, rash, aches and pains

Consulte a su médico si alguno de estos le causa molestias

Changes to the results of some medical tests

Su médico verificará estos

Importante: si experimenta síntomas como rigidez muscular, una temperatura muy alta (fiebre), confusión, un ritmo cardíaco rápido y sudoración, debe contactar a su médico de inmediato. Estos pueden ser signos de una condición rara pero grave conocida como síndrome neuroléptico maligno.

Sf you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice.

How to store paliperidone

  • Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

If you suspect that you have had an overdose of this medicine, contact your doctor or go to the accident and emergency department of your local hospital.

Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.

Informar efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

verificador de síntomas

¿Inseguro sobre mezclar medicamentos?

Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.

Preguntas frecuentes

What should I do if I miss an appointment for my paliperidone injection?

It is important to contact your doctor as soon as possible to reschedule your appointment if you miss one. This ensures you receive your injection without further delay, which is crucial for the effectiveness of the treatment.

Are there any specific concerns if I have diabetes and am taking paliperidone?

Yes, if you have diabetes, you might need to check your blood glucose levels more often. Paliperidone can affect your blood sugar, so your doctor will provide specific advice on how to manage this while on the medication.

Can I take other medications, including over-the-counter or herbal remedies, while on paliperidone?

Before taking any other medicines, including those available without a prescription, or any herbal and complementary medicines, you should check with a pharmacist to ensure they are suitable to take with paliperidone. Some medications can interact negatively.

What is 'floppy iris syndrome' and why is it important to tell my surgeon about paliperidone before cataract surgery?

'Floppy iris syndrome' is an eye problem that has been observed in some people taking paliperidone. If you are having cataract surgery, it is particularly important to inform your surgeon about your medication so they can advise you on the potential risks and take necessary precautions during the procedure.

What should I do if I think I'm experiencing Neuroleptic Malignant Syndrome?

If you experience symptoms like muscle stiffness, a very high temperature (fever), confusion, a fast heartbeat, and sweating, you should contact your doctor immediately. These could be signs of a rare but serious condition called neuroleptic malignant syndrome.

Lecturas adicionales y referencias

Sobre el autorVer biografía completa

Imagen del autor

Michael Stewart, MRPharmS

Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico

BPharm (Hons), MRPharmS

Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.

Acerca del revisor

Imagen del autor

Sid Dajani

Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.

Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • Next review due: 24 Aug 2027
  • 17 Ago 2024 | Última versión

    Última actualización por

    Michael Stewart, MRPharmS

    Revisado por pares por

    Sid Dajani
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