Paliperidone long-acting injection
Xeplion, Trevicta, Byannli
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 17 ago 2024
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Paliperidone long-acting injection will be given to you by your doctor or nurse every four weeks to begin with.
If you miss an appointment for an injection, please make another appointment as soon as possible.
The most common side-effects are headache and difficulties sleeping.
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About paliperidone long-acting injection
Tipo de medicamento | Un medicamento antipsicótico |
Utilizado para | Schizophrenia in adults |
También llamado | Xeplion®; Trevicta®; Byannli® |
Disponible como | Long-acting intramuscular depot injection |
Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. You will have been prescribed paliperidone to relieve the symptoms of schizophrenia. Such symptoms include hearing, seeing, or sensing things that are not real, having mistaken beliefs and feeling unusually suspicious. Paliperidone works on the balance of chemical substances in your brain to help control these types of symptoms.
Long-acting or 'depot' injections are used for maintenance once your symptoms have been eased by taking tablets. The injection slowly releases paliperidone into your body. You will need to receive the injection regularly, once every month. A three-monthly injection (Trevicta®) is available for people who are stable on once-monthly injections. There is also a six-monthly injection (Byannli®). The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Before having paliperidone injection
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having paliperidone injections, it is important that your doctor knows:
Si está embarazada o en periodo de lactancia.
Si padece una cardiopatía o una enfermedad vascular.
Si tiene problemas de hígado, riñón o próstata.
Si tiene problemas para respirar.
If you have any of the following: epilepsy, depression, Parkinson's disease, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called myasthenia gravis.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice) or a blood disorder.
If you are scheduled to have eye cataract surgery.
If you have a tumour on your adrenal gland (a condition called phaeochromocytoma), or if you have been told you have 'a prolactin-dependent tumour'.
Si ha tenido una reacción alérgica a un medicamento.
Si toma o utiliza otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.
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How paliperidone long-acting injection is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about paliperidone and it will also provide you with a full list of the side-effects which you may experience from having it.
Paliperidone injection will be given to you by your doctor or nurse. The first two doses will be injected into a muscle in your upper arm. After this, the injections can either be given into a muscle in your arm, or if preferred, the buttocks.
If you haven't received paliperidone injection before, you will initially be given a dose of 150 mg and then a dose of 100 mg a week later. From then on, you will need to have one injection each month. Your doctor will adjust the amount of paliperidone given to suit what is right for you.
When your dose of once-monthly injection is stabilised, a three-monthly injection is available and may be suitable for you.
Aproveche al máximo su tratamiento
Your treatment will require careful monitoring to make sure that you get the best possible benefit from paliperidone. Keep your regular doctor's appointments so that you get your injections on time and your progress can be checked. If you miss an appointment for an injection, contact your doctor to arrange for another appointment as soon as possible. This is so that you can be given the injection without any further delay.
If you are due to have any dental treatment or an operation, please tell the person carrying out the treatment that you have had a paliperidone injection. This is important because it may interfere with any anaesthetic you receive. If you are having cataract surgery, it is particularly important that you tell your surgeon that you are on paliperidone. This is because an eye problem known as 'floppy iris syndrome' has developed in some people and your doctor will want to advise you about the risks of this.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with paliperidone.
If you have diabetes you may need to check your blood glucose more frequently, as paliperidone may affect the levels of sugar in your blood. Your doctor will advise you about this.
If you drink alcohol, please ask your doctor for advice. Alcohol increases the risk of side-effects from paliperidone, so it is best avoided.
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Can paliperidone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with paliperidone long-acting injection. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common paliperidone injection side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si me ocurre esto? |
Difficulties sleeping | Discuss this with your doctor if it becomes troublesome |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza persisten, informe a su médico. |
Common paliperidone injection side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si me ocurre esto? |
Pain at the site of the injection | This should quickly pass. If the area becomes red, swollen or 'lumpy', let your doctor know |
Sensación de mareo, cansancio o sueño | No conduzca ni utilice herramientas o máquinas. No beba alcohol |
Feeling shaky or restless, unusual or uncontrollable movements | Hable con su médico |
Malestar (náuseas) o náuseas (vómitos), indigestión, molestias abdominales | Stick to simple meals - avoid rich or spicy food |
Diarrea | Beber mucha agua para reponer los líquidos perdidos |
Estreñimiento | Drink plenty of water and eat a well-balanced diet |
Increased infections, weight increase or loss, mood changes, high blood pressure, toothache, rash, aches and pains | Coméntelo con su médico si alguno le resulta molesto |
Changes to the results of some medical tests | Su médico comprobará |
Importante: si experimenta síntomas como rigidez muscular, temperatura muy alta (fiebre), sensación de confusión, taquicardia y sudoración, debe ponerse en contacto con su médico inmediatamente. Pueden ser signos de una enfermedad rara pero grave conocida como síndrome neuroléptico maligno.
Si experimenta cualquier otro síntoma que considere que puede deberse al medicamento, consulte a su médico o farmacéutico.
How to store paliperidone
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
If you suspect that you have had an overdose of this medicine, contact your doctor or go to the accident and emergency department of your local hospital.
Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.
Informar de los efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.
Lecturas complementarias y referencias
- Manufacturer's PIL, Xeplion® prolonged-release suspension for injection; Janssen-Cilag Ltd, The electronic Medicines Compendium. Dated June 2023.
- Manufacturer's PIL, Trevicta® 175 mg prolonged release suspension for injection; Janssen-Cilag Ltd, The electronic Medicines Compendium. Dated June 2023.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Fecha de la próxima revisión: 24 de agosto de 2027
17 ago 2024 | Última versión

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