Mefloquina para la prevención del paludismo
Lariam
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 18 Ene 2024
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Mefloquine tablets help to protect against malaria when travelling to a country where malaria occurs.
It is important that you start taking the tablets before you travel - the usual recommendation is to start the course of tablets 2-3 weeks before you travel. This allows the level of medicine in your body to become effective, and it also gives time to check for any side-effects before you travel. Continue to take a tablet on the same day of each week during your stay, and for four weeks after you return.
Mefloquine is only one of a number of measures that you need to take to reduce your risk of malaria. Others include wearing suitable clothing, using insect repellents and sleeping in screened rooms or beds.
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About mefloquine
Tipo de medicamento | Un medicamento antipalúdico |
Utilizado para | To prevent malaria (it is also used to treat malaria infection) |
También llamado | Lariam® |
Disponible como | Tabletas |
Mefloquine tablets help to protect you from malaria when you travel to areas where this can be a problem. Malaria is a serious infection. It is common in tropical countries such as parts of Africa, Asia, South and Central America, and the Middle East. Malaria is a disease which is passed on to humans by infected mosquitoes. A parasite called plasmodium lives inside the stomachs of infected female mosquitoes and is passed on to humans by a bite. Mefloquine works by killing the parasites passed into your body from the bites of the infected mosquitoes.
Dado que el patrón del paludismo varía en función de la parte del mundo a la que se viaja, así como de la estación del año y el tipo de actividad que se ha planeado, siempre se deben obtener los últimos consejos sobre la prevención del paludismo de su médico, farmacéutico u organizador de viajes. Un viaje de mochilero puede requerir medidas preventivas contra el paludismo diferentes de las necesarias para un viaje de negocios a una ciudad.
Mefloquine tablets are not available on the NHS, although you will require a prescription from a doctor to obtain them. You will be given a private (non-NHS) prescription to take to your local pharmacy, and you will be asked to pay for the tablets when they are supplied.
Mefloquine can sometimes be given to treat malaria in people who have become infected. This leaflet does not contain information about this, but your doctor can give you more information if you have been prescribed it for this reason.
Before taking mefloquine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking mefloquine it is important that your doctor or pharmacist knows:
Si está embarazada, esperando un bebé o en período de lactancia.
If you have epilepsy or have ever had fits (convulsions).
Si padece una enfermedad cardiaca.
Si alguna vez ha padecido depresión, ansiedad grave o cualquier otro problema de salud mental.
Si tiene algún problema con el funcionamiento del hígado o de los riñones.
If you have had Blackwater fever (a complication of malaria infection).
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.
If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have ever had a bad reaction to a medicine called quinine.
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How to take mefloquine
Before you take mefloquine, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about mefloquine. It will also provide you with a full list of the side-effects which you may experience from taking it and what to do if you experience them.
Take the tablets exactly as your doctor tells you to. The dose to prevent malaria in an adult is one 250 mg tablet once a week. Your dose will be printed on the label of the pack to remind you. (If you have malaria and you are taking mefloquine to treat it, your dose will be different to this.) If you are giving mefloquine to a child, the dose prescribed will depend on the weight of your child. Check the label carefully to make sure you are giving the correct dose.
Start taking the course of tablets 2-3 weeks before you travel and continue to take them for four weeks after you return. Take the tablet on the same day of the week. If you develop any side-effects in the 2-3 weeks before you travel, speak with your doctor for further advice.
Swallow the tablet with a drink of water during a mealtime (or just after a snack). If you prefer, the tablet can be crushed and mixed with a little food, such as jam or honey, to make it easier to swallow.
If you forget to take a dose, take it as soon as you remember and then continue with your next dose on the usual day. Do not take two doses at the same time. You must complete the full course of tablets unless you are told otherwise by a doctor.
Aproveche al máximo su tratamiento
Estas pastillas le ayudarán a prevenir el paludismo, pero también es importante que tome las siguientes precauciones contra las picaduras de mosquitos:
Cubra las zonas descubiertas de brazos y piernas con ropa holgada de manga larga, pantalones largos y calcetines. Esto es especialmente importante si está al aire libre después de la puesta de sol, ya que es cuando se alimentan los mosquitos.
Utiliza un spray repelente de insectos eficaz en la ropa y en cualquier zona de la piel que tengas descubierta. Si también utiliza un protector solar, aplíquese primero el protector solar y después el repelente de insectos.
Rocía la habitación con un insecticida cada noche un par de horas antes de acostarte. Comprueba si hay mosquitos en las zonas donde duermes: presta especial atención a los muebles y a las zonas bajo la cama, donde pueden esconderse los insectos.
Si duerme en una habitación sin mosquitera, utilice una mosquitera impregnada con insecticida.
It is possible that mefloquine may make you feel dizzy and affect your balance. These effects may continue for a while, even after you have stopped mefloquine. Make sure you know how you react before you drive and before you use machines or tools.
Your doctor will discuss with you the possibility of other unwanted side-effects. If you develop any changes in your moods, thoughts or behaviour, you should see your doctor before your next dose is due so that you can be given an alternative antimalarial medicine.
If you have been advised to have an oral vaccine to protect you against typhoid, you should arrange to have this at least three days before you start taking mefloquine. This is because mefloquine can stop the vaccine from working properly.
If you buy any other medicines to take, check with a pharmacist that they are safe to take alongside mefloquine.
Si se encuentra mal o tiene fiebre o síntomas gripales durante el viaje o en el plazo de un año (sobre todo si son tres meses) después de volver a casa, acuda inmediatamente al médico. Esto es importante, incluso si ha tomado correctamente los comprimidos antipalúdicos.
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Can mefloquine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with mefloquine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common mefloquine side-effects | ¿Qué puedo hacer si me ocurre esto? |
Sentirse mal (náuseas) o estar enfermo (vómitos), dolor de estómago | Stick to simple meals - avoid spicy or rich foods |
Diarrea | Beber mucha agua para reponer los líquidos perdidos |
Feeling dizzy, loss of balance, problems with vision | Do not drive and do not use tools or machines. Symptoms may continue for some time even after you have stopped taking mefloquine |
Dolor de cabeza | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know before you travel |
Difficulties sleeping, itchy skin | En caso de molestias, hable con su médico |
Nightmares, feelings of panic, restlessness or anxiety, depression, confusion | Stop taking mefloquine tablets and speak with a doctor to obtain an alternative antimalarial lo antes posible (this must be before your next dose would be due) |
If you experience any other symptoms which you think may be due to the tablets, discuss them with your doctor or pharmacist who will be able to advise you further.
How to store mefloquine
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.
Si va a someterse a una operación o a un tratamiento dental, comunique a la persona que lleve a cabo el tratamiento qué medicamentos está tomando.
Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.
No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.
Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.
MHRA - Notificación de reacciones adversas
Notifique a la Agencia Reguladora de Medicamentos y Productos Sanitarios las sospechas de efectos secundarios de medicamentos, vacunas, cigarrillos electrónicos, incidentes con productos sanitarios o productos defectuosos o falsificados para garantizar un uso seguro y eficaz.
Lecturas complementarias y referencias
- Manufacturer's PIL, Lariam® 250 mg tablets; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated March 2023.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Fecha de la próxima revisión: 17 de enero de 2027
18 Ene 2024 | Última versión

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