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Linaclotide capsules

Constella

Take one capsule once daily.

Take the capsule at least half an hour before food.

The most common side-effect is diarrhoea. Let your doctor know if this becomes severe or lasts for longer than a week.

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About linaclotide

Tipo de medicamento

Guanylate cyclase-C receptor agonist

Utilizado para

Constipation associated with irritable bowel syndrome in adults

También llamado

Constella®

Disponible como

Cápsulas

Irritable bowel syndrome (IBS) is a common disorder. Symptoms can be quite variable, and can come and go. Typical symptoms include tummy (abdominal) pain, bloating, and bouts of constipation and/or diarrhoea. Linaclotide can be useful for people who have constipation as one of the main symptoms of IBS. It helps to increase bowel secretions and movement, making stools easier to pass, and it also helps to ease pain and discomfort.

Before taking linaclotide

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking linaclotide it is important that your doctor knows:

  • Si está embarazada o en periodo de lactancia.

  • Si está tan estreñido que cree que puede tener una obstrucción.

  • Si alguna vez ha tenido una reacción alérgica a un medicamento.

  • Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.

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How to take linaclotide capsules

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about linaclotide and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take linaclotide exactly as your doctor tells you to. It is taken once daily. You can take your dose at a time of day that suits you, but try to take it at around the same time of day, each day.

  • Swallow the capsule whole with a drink of water. It is best taken on an empty stomach (which means at least 30 minutes before food). This is because taking the capsules with food increases the possibility that diarrhoea will occur.

  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the forgotten dose. Do not take two doses at the same time to make up for a missed dose.

Aproveche al máximo su tratamiento

  • Procure acudir a las citas periódicas con su médico. Así podrá comprobar su evolución.

  • A healthy diet containing fibre (wholegrain breads and cereals, bran, fruit and green leafy vegetables) with several glasses of water each day and daily exercise are important in maintaining healthy bowel function.

  • You can read our leaflet called Fibre and Fibre Supplements for advice on ways to increase the amount of fibre in your diet.

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Can linaclotide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with linaclotide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common linaclotide side-effects

¿Qué puedo hacer si me ocurre esto?

Diarrea

Drink plenty of water, and make sure that you take the capsules at least 30 minutes before food. If the diarrhoea is severe or continues for more than a week, let your doctor know

Wind, tummy (abdominal) discomfort

En caso de molestias, hable con su médico

Sensación de mareo

No conduzca ni utilice herramientas o máquinas mientras se sienta mareado.

If you notice any bleeding from your back passage whilst taking linaclotide, let your doctor know. This could be due to piles (haemorrhoids) caused by your constipation or due to the treatment itself.

Si experimenta cualquier otro síntoma que considere que puede deberse al medicamento, consulte a su médico o farmacéutico.

How to store linaclotide

  • Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.

  • Store in a cool, dry place, away from direct heat and light. The capsules can absorb moisture from the air so it is important to keep them in their original container (which contains a desiccant to keep them dry). Do not keep the capsules for longer than 18 weeks after the container is first opened.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.

Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.

If you are having an operation or dental treatment, tell the person carrying out the treatment what medicines you are taking.

Si compra algún medicamento, compruebe siempre con un farmacéutico que es adecuado para tomarlo con sus otros medicamentos.

No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.

Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.

Informar de los efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.

Lecturas complementarias y referencias

Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • Fecha de la próxima revisión: 18 de septiembre de 2026
  • 19 Sept 2023 | Última versión

    Última actualización

    Michael Stewart, MRPharmS

    Revisado por expertos

    Sid Dajani
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