Mesalazina

About mesalazine

Ulcerative colitis causes inflammation of the intestine which leads to problems such as ulceration and bleeding. This causes symptoms such as abdominal pain and diarrhoea. Crohn's disease is a condition which causes inflammation of any part of the gastrointestinal system. When the inflammation is in the area where the small intestine joins the large intestine, then it is called Crohn's ileo-colitis. Aminosalicylates are a group of medicines commonly used to treat inflammatory bowel diseases such as these. Mesalazine is one of the most commonly used aminosalicylates.

Although it is not clear exactly how mesalazine works, it is thought to act on cells lining the intestine to change the way these cells make and release certain chemicals. These chemicals are thought to be a factor in causing the symptoms of ulcerative colitis. Mesalazine allows the damaged intestine to recover and helps to prevent symptoms from flaring up again.

There are a number of different mesalazine preparations and brands. The way the manufacturers make each of these brands differs slightly; this allows the different brands to release mesalazine in specific areas of the intestine. You will be prescribed the brand that allows mesalazine to be released in the part of your intestine which requires it most.

Mesalazine can be taken by mouth as granules or tablets, or it can be given into the back passage as a suppository, rectal foam or enema.

Before taking mesalazine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking mesalazine it is important that your doctor knows:

• If you are pregnant or breastfeeding. (Although mesalazine is unlikely to be harmful to babies, it is still important that you tell your doctor if you are expecting or breastfeeding a baby.)

• Si tiene algún problema con el funcionamiento de su hígado, o si tiene algún problema con el funcionamiento de sus riñones.

• Si tiene problemas para respirar.

• If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have had an unusual reaction to aspirin or a salicylate.

• Si toma o utiliza otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.
  

How to take mesalazine

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about mesalazine, and it will also provide you with a full list of the side-effects which you could experience.

• Your dose will depend upon which brand of mesalazine has been prescribed for you. Your doctor will tell you how much to take and when to take it, and these directions will also be printed on the label of the pack to remind you about what the doctor said to you. Take mesalazine exactly as your doctor tells you to.

• Some mesalazine tablets and granules are specially coated to pass through your stomach before they are absorbed. These must be swallowed whole and not broken, chewed or crushed. Check the label on your pack carefully and follow any advice it gives. Also, do not take any indigestion remedies within two hours of taking your doses (either before or after), as this will interfere with the special coating.

• If you have been given the Mezavant® XL brand of tablets, you should take these after a meal. If you have been given any other brand of tablet, it is unimportant whether you take them before or after a meal.

• If you have been given granules, place the correct amount on to your tongue and wash them down with a drink of water. Do not chew the granules. You can take them either before or after meals. Alternatively the entire contents of the sachet can be poured onto a yoghurt and eaten straightaway.

• Si olvida tomar una dosis, tómela en cuanto se acuerde (a menos que sea casi la hora de la siguiente dosis, en cuyo caso omita la dosis olvidada y tome la siguiente dosis normalmente). No tome dos dosis juntas para compensar la dosis olvidada.

How to use mesalazine enema

1. Shake the enema and release the seal on the nozzle.

2. Lie down on one side and draw your top knee up towards your chest. Insert the enema nozzle into your back passage.

3. Squeeze the bottle gently to completely empty the contents. This will take around 30-40 seconds. Remove the nozzle from your back passage. Remain where you are for about 5-10 minutes until the urge to pass the enema has eased.

4. Throw away the empty enema bottle in a plastic bag (these are provided with some brands of enema).

5. Lávate las manos.

How to use mesalazine foam enema

1. Shake the can well to mix the contents.

2. Before you use the can for the first time, remove the plastic safety lock.

3. Push the plastic applicator on to the nozzle of the can.

4. Stand up and place one foot on a firm surface, such as a chair.

5. Hold the canister upside down (with the dome facing down) in the palm of your hand.

6. Insert the applicator into your back passage as far as is comfortable.

7. Push the dome once and release it. This will release one dose of the foam. Repeat if you need two doses.

8. Remove the applicator and place it in one of the plastic bags provided and dispose of it in a bin.

9. Lávate las manos.

How to use mesalazine suppositories

1. Remove the suppository from the packaging.

2. Using your finger, gently push the suppository into your back passage (rectum). Some people find it helps to squat, or to lie down on one side and draw their knees up towards their chest to do this.

3. Push the suppository in as far as is comfortable. You may have the urge to pass the suppository out again but this should ease after a few minutes.

4. Lávate las manos.

Aproveche al máximo su tratamiento

• Each time you collect a new supply from your pharmacy, check to see if it is the same brand as before. If it is different, discuss this with your pharmacist who will advise you.

• Try to keep your regular appointments with your doctor and clinic. This is so your doctor can check on your progress. Your doctor will want you to have regular blood tests during the treatment.

• Treatment with mesalazine may be long-term to prevent symptom flare-ups. Continue to take/use it unless you are advised otherwise.

• Your doctor may advise you make some changes to your diet as part of your treatment. This can include a special diet or a nutritional supplement.

• It is important to stay hydrated whilst being treated with mesalazine, ensure you drink the recommended amount of fluids each day.

• You may notice a red-brown discolouration of urine when in contact with certain bleaches used to clean toilets. This is not harmful.

Can mesalazine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with mesalazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Si experimenta cualquier otro síntoma que considere que puede deberse al medicamento, consulte a su médico o farmacéutico.

How to store mesalazine

• Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.

• Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos