Olsalazina para la colitis ulcerosa
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 18 Mar 2023
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Take olsalazine tablets or capsules with a meal or after a snack.
It is important that you keep your regular appointments with your doctor so that your progress can be checked. You will need to have regular blood tests.
Common side-effects tend to be minor, but on occasions, olsalazine can cause more serious problems. You should tell your doctor immediately if you have any unexplained bleeding, bruising, red or purple discolorations of your skin, a sore throat, a high temperature (fever) or you feel generally unwell.
De un vistazo
Olsalazine is a medicine used to treat ulcerative colitis in adults and children over 12.
It helps to reduce inflammation in the large intestine and prevent flare-ups of symptoms.
Take olsalazine with or after food to help minimise side-effects like diarrhoea.
You will need regular blood tests during your treatment with olsalazine.
Seek medical help immediately if you have breathing difficulties, swelling, or unexplained bleeding.
About olsalazine
Tipo de medicamento | Aminosalicylate |
Usado para | Ulcerative colitis in adults and in children aged over 12 years |
Disponible como | Capsules and tablets |
Colitis ulcerosa causes inflammation of the large intestine. This can lead to damage to the lining of your intestine (ulceration) and bleeding, and causes symptoms of tummy (abdominal) pain and diarrhoea.
Although it is not clear exactly how olsalazine works, it is thought to act on the cells which line your intestine to change the way they make and release certain chemicals. These chemicals are thought to be a factor in causing the symptoms of ulcerative colitis. Olsalazine allows the damaged areas of your intestine to recover, and then helps to prevent your symptoms from flaring up again.
Before taking olsalazine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking olsalazine it is important that your doctor or pharmacist knows:
Si estás embarazada, intentando tener un bebé o amamantando.
Si tienes algún problema con el funcionamiento de tus riñones.
If you have asthma and/or experience severe allergies.
If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have had an unusual reaction to aspirin or to any other salicylate medicine.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
How to take olsalazine
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about olsalazine and a full list of side-effects which you may experience from taking it.
Take olsalazine exactly as your doctor tells you to. He or she will tell you how many tablets/capsules to take for each dose, and when to take them.
Your dose may be increased over the first few weeks to make sure that you are taking a dose that best controls your symptoms.
Your dose may be reduced again once your symptoms have improved.
It is likely that you will be asked to take olsalazine twice each day, usually morning and evening. Some people may be asked to take it three times each day for a short while. The directions will be printed on the label of your pack to remind you.
Take olsalazine tablets or capsules with a drink of water during a meal, or straightaway after a meal. Taking olsalazine with or after food will help to keep side-effects, like diarrhoea, to a minimum.
If you forget to take a dose, take it as soon as you remember unless your next dose is due. If when you remember it is nearly time for your next dose, then leave out the forgotten dose but remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Try to keep your regular appointments with your doctor and clinic. This is so your doctor can check on your progress. Your doctor will want you to have regular blood tests during this treatment.
Treatment with olsalazine may be long-term in order to prevent your symptoms from flaring up from time to time. Continue to take it unless you are advised otherwise by your doctor.
Your doctor may advise you make some changes to your diet as part of your treatment. This may include a special diet or a nutritional supplement.
If you have an allergic condition, such as asthma, you should let your doctor know straightaway if you find your allergic symptoms get worse. If this happens, your doctor may want to review your treatment or will arrange to see you more often to keep an eye on your progress.
Can olsalazine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with olsalazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common olsalazine side-effects - these affect fewer than 1 in 10 people who take this medicine | ¿Qué puedo hacer si experimento esto? |
Diarrea | Drink plenty of water to replace lost fluids. Make sure you take olsalazine after meals |
Sentirse enfermo (náuseas) o estar enfermo (vómitos), indigestión, dolor de estómago (abdominal) | Mantente en alimentos simples - evita comidas ricas o picantes |
Headache, joint or muscle pain | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the pain continues, speak with your doctor |
Importante: olsalazine can sometimes cause allergic reactions or problems with your blood cells. You should contact your doctor immediately if:
You have any difficulty in breathing, or any swelling of your face or tongue.
You have any unexplained bleeding, bruising, red or purple discolorations on your skin, a sore throat, a high temperature (fever), or if you feel generally unwell during this treatment.
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store olsalazine
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Si compras algún medicamento, consulta con un farmacéutico que sea seguro tomarlo junto con tus otros medicamentos.
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What is ulcerative colitis?
Ulcerative colitis is a condition that causes inflammation in the large intestine. This inflammation can damage the lining of the intestine, leading to ulcers and bleeding, and causing symptoms such as abdominal pain and diarrhoea.
How does olsalazine help with ulcerative colitis?
While the exact mechanism isn't fully understood, olsalazine is believed to work by affecting the cells lining your intestine. It changes how these cells produce and release certain chemicals thought to contribute to ulcerative colitis symptoms. By doing this, it helps damaged areas of the intestine to heal and prevents future flare-ups of symptoms.
Are there any specific allergies to be concerned about before taking olsalazine?
Yes, it is particularly important to inform your doctor if you have ever had an unusual reaction to aspirin or any other salicylate medicine, as olsalazine is an aminosalicylate. You should also tell your doctor if you have other severe allergies or asthma.
What should I do if I forget to take a dose of olsalazine?
If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, then skip the one you missed and just take your next dose when it's due. Do not take two doses together to try and make up for a forgotten dose.
What kind of blood tests will my doctor order while I'm on olsalazine?
Your doctor will want you to have regular blood tests during your treatment with olsalazine. These tests are important for monitoring your progress and ensuring the treatment is suitable for you.
Can I stop taking olsalazine if my symptoms improve?
Treatment with olsalazine is often long-term, designed to prevent your symptoms from recurring. You should continue to take it regularly unless your doctor specifically advises you to stop.
Will I need to change my diet while taking olsalazine?
Your doctor might recommend specific dietary changes as part of your overall treatment plan for ulcerative colitis. This could involve a special diet or a nutritional supplement. You should discuss this with your doctor.
Lecturas adicionales y referencias
- Manufacturer's PIL, Olsalazine sodium 250 mg Capsules; Atnahs Pharma UK Ltd, The electronic Medicines Compendium. Dated May 2021.
- Manufacturer's PIL, Olsalazine sodium 500 mg tablets; Atnahs Pharma UK Ltd, The electronic Medicines Compendium. Dated May 2021.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Next review due: 17 Sept 2027
18 Mar 2023 | Última versión

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