Agomelatine tablets
Valdoxan
Revisado por pares por Dr Colin Tidy, MRCGPÚltima actualización por Michael Stewart, MRPharmSLast updated 14 Abr 2025
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Take agomelatine once a day, at bedtime.
It can take a week or two after starting the tablets before the effect builds up and you start to feel the benefit. If you do not feel you have improved after this time, go back and talk with your doctor.
The most common side effects of agomelatine are feeling dizzy or sick (nausea) - these are usually mild and soon pass.
Rarely, agomelatine can affect the way your liver works. If you develop dark urine, pale stools, any yellowing of your skin or the whites of your eyes, pain in your tummy (abdomen), or feel unusually tired, you must let your doctor know about this straightaway.
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Video picks for Medicamentos para el sistema nervioso
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About agomelatine
Tipo de medicamento | A melatonin agonist |
Usado para | Depresión |
También llamado | Valdoxan® |
Disponible como | Comprimidos |
What is agomelatine used for?
Volver al contenidoAgomelatine is an atypical antidepressant used to treat depresión.
Depression is common and symptoms can affect day-to-day life and can become very distressing. Treatments include talking (psychological) treatments and antidepressant medicines.
Our bodies follow a daily cycle, called circadian rhythms, which control sleep and other functions. When these rhythms are disrupted, it can lead to depression. Agomelatine helps depression by restoring this natural balance.
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Side effects of agomelatine
Volver al contenidoThe most common side effects of agomelatine are:
Náuseas.
Diarrea.
Feeling dizzy, tired or sleepy.
Dolor de cabeza
Estreñimiento.
Dolor estomacal.
Difficulty sleeping.
Feeling anxious.
Increased sweating.
Back pain.
Encontrará una lista completa en el prospecto del fabricante que se suministra con su medicamento. Los efectos no deseados a menudo mejoran a medida que su cuerpo se adapta al nuevo medicamento, pero hable con su médico o farmacéutico si alguno de los siguientes persiste o se vuelve problemático.
How to manage agomelatine side effects
Volver al contenidoCommon agomelatine side effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling sick, diarrhoea | Stick to simple foods (avoid fatty or spicy meals) and drink plenty of water |
Sintiéndose mareado, cansado o somnoliento | Do not drive and do not use tools or machines. Do not drink alcohol |
Dolor de cabeza | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor |
Constipation, tummy pain | Try to eat a well-balanced diet containing fresh fruit and vegetables. Drink plenty of water |
Difficulty sleeping, feeling anxious, increased sweating, back pain | These effects are usually mild and soon pass but if any become troublesome, speak with your doctor |
Importante: if you notice any of the following you should contact your doctor straightaway as it could be a sign of a problem with your liver:
Dark urine or light-coloured stools.
Estar enfermo (vómitos)
Pain in your tummy (abdomen).
Any yellowing of your skin or the whites of your eyes (jaundice).
Itchy skin or unexplained bruising.
Pérdida de apetito.
Any unexplained flu-like symptoms.
Feeling unusually tired or generally unwell.
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, hable con su médico o farmacéutico para obtener más consejos.
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Who should not take agomelatine?
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking agomelatine it is important that your doctor knows:
If you are under 18 or over 75 years of age.
Si estás embarazada o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado, o si tienes algún problema con el funcionamiento de tus riñones.
If you have ever had abnormally 'high' moods or dementia.
If you regularly drink large amounts of alcohol.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que se pueda comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take agomelatine
Volver al contenidoRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about agomelatine, and will also provide you with a full list of the side effects which you could experience from taking it.
Take agomelatine exactly as your doctor tells you to. The usual dose is one tablet daily. This may be increased in some people to two tablets daily (taken together) after a couple of weeks.
You should take the tablets at bedtime. The tablets can be taken either with or without food.
If you forget to take a dose, do not worry, just take the next dose when it is due.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIt can take a week or two after starting the tablets before the effect begins to build up, and maybe a few weeks longer before you feel the full benefit from the treatment. Do not stop taking agomelatine after a few days, thinking it is not helping.
Try to keep your regular appointments with your doctor. This is because your doctor will want you to have a blood test every few weeks to check that your liver is staying healthy.
Your doctor will also give you a booklet to read which explains about what symptoms to look out for as signs that the medicine could be harming your liver. There is a list of these symptoms in the section below on the problems which can be caused by agomelatine.
While you feel depressed or are taking agomelatine, you may have thoughts about harming yourself or ending your life. It is very important that you tell your doctor about this straightaway if it happens to you.
Taking agomelatine and alcohol is not recommended, so do not drink alcohol during your treatment with this medicine.
Smoking can affect the amount of agomelatine in your body. Let your doctor know if you either start or stop smoking while you are taking agomelatine.
Your doctor will ask you to carry on taking agomelatine for a while after you feel better. This is to stop your symptoms from returning.
There are several types of antidepressants and they differ in their possible side effects. If you find that agomelatine does not suit you then let your doctor know, as another could be found that will suit you.
How to store agomelatine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
If you buy any medicines, check with a pharmacist that they are safe to take with your prescribed medicines.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.
Preguntas frecuentes
Volver al contenidoIs agomelatine a strong antidepressant?
Agomelatine is not considered a “strong” antidepressant in the traditional sense, but it can be effective for some people. It works differently to many other antidepressants, helping regulate sleep as well as mood.
Does agomelatine cause weight gain?
Agomelatine is less likely to cause weight gain than many other antidepressants. While changes in weight can happen for some people, they are not usually common side effects.
What class of drug is agomelatine?
Agomelatine belongs to a class of antidepressants known as melatonergic antidepressants. It works differently from SSRIs and SNRIs by acting on melatonin and serotonin receptors, which may help improve sleep patterns as well as mood.

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Lecturas adicionales y referencias
- Manufacturer's PIL, Valdoxan® 25 mg tablets; Servier Laboratories Limited, The electronic Medicines Compendium. Dated August 2023.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 14 Abr 2028
14 Abr 2025 | Última versión

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