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Agomelatina comprimidos

Valdoxan

Take agomelatine once a day, at bedtime.

It can take a week or two after starting the tablets before the effect builds up and you start to feel the benefit. If you do not feel you have improved after this time, go back and talk with your doctor.

The most common side-effects are feeling dizzy or sick (nausea) - these are usually mild and soon pass.

Rarely, agomelatine can affect the way your liver works. If you develop dark urine, pale stools, any yellowing of your skin or the whites of your eyes, pain in your tummy (abdomen), or feel unusually tired, you must let your doctor know about this straightaway.

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About agomelatine

Tipo de medicamento

A melatonin agonist

Utilizado para

Depresión

También llamado

Valdoxan®

Disponible como

Tabletas

Depression is common. Symptoms can affect day-to-day life and can become very distressing. Treatments include talking (psychological) treatments and antidepressant medicines.

Our bodies have a number of important physical and behavioural processes which are controlled by the cycling of day and night. These are called circadian rhythms and, if disrupted, can result in depression. Agomelatine relieves depression by helping to restore the balance of these biological rhythms.

Before taking agomelatine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking agomelatine it is important that your doctor knows:

  • If you are under 18 or over 75 years of age.

  • Si está embarazada o en periodo de lactancia.

  • Si tiene algún problema con el funcionamiento de su hígado, o si tiene algún problema con el funcionamiento de sus riñones.

  • If you have ever had abnormally 'high' moods or dementia.

  • If you regularly drink large amounts of alcohol.

  • Si está tomando otros medicamentos. Esto incluye todos los medicamentos que se pueden comprar sin receta, así como las hierbas medicinales y los medicamentos complementarios.

  • Si alguna vez ha tenido una reacción alérgica a un medicamento.

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How to take agomelatine

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about agomelatine, and will also provide you with a full list of the side-effects which you could experience from taking it.

  • Take agomelatine exactly as your doctor tells you to. The usual dose is one tablet daily. This may be increased in some people to two tablets daily (taken together) after a couple of weeks. You should take the tablets at bedtime. The tablets can be taken either with or without food.

  • If you forget to take a dose, do not worry, just take the next dose when it is due.

Aproveche al máximo su tratamiento

  • It can take a week or two after starting the tablets before the effect begins to build up, and maybe a few weeks longer before you feel the full benefit from the treatment. Do not stop taking agomelatine after a few days, thinking it is not helping.

  • Try to keep your regular appointments with your doctor. This is because your doctor will want you to have a blood test every few weeks to check that your liver is staying healthy. Your doctor will also give you a booklet to read which explains about what symptoms to look out for as signs that the medicine could be harming your liver. There is a list of these symptoms in the section below on the problems which can be caused by agomelatine.

  • While you feel depressed or are taking agomelatine, you may have thoughts about harming yourself or ending your life. It is very important that you tell your doctor about this straightaway if it happens to you.

  • Taking agomelatine and alcohol is not recommended, so do not drink alcohol during your treatment with this medicine.

  • Smoking can affect the amount of agomelatine in your body. Let your doctor know if you either start or stop smoking while you are taking agomelatine.

  • Your doctor will ask you to carry on taking agomelatine for a while after you feel better. This is to stop your symptoms from returning.

  • There are several types of antidepressants and they differ in their possible side-effects. If you find that agomelatine does not suit you then let your doctor know, as another could be found that will suit you.

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Can agomelatine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with agomelatine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common agomelatine side-effects (these affect fewer than 1 in 10 people)

¿Qué puedo hacer si me ocurre esto?

Sensación de malestar (náuseas), diarrea

Stick to simple foods (avoid fatty or spicy meals) and drink plenty of water

Sensación de mareo, cansancio o sueño

No conduzca ni utilice herramientas o máquinas. No beba alcohol

Dolor de cabeza

Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor

Constipation, tummy (abdominal) pain

Try to eat a well-balanced diet containing fresh fruit and vegetables. Drink plenty of water

Difficulty sleeping, feeling anxious, increased sweating, back pain

These effects are usually mild and soon pass but if any become troublesome, speak with your doctor

Important: if you notice any of the following you should contact your doctor straightaway as it could be a sign of a problem with your liver:

  • Dark urine or light-coloured stools.

  • Estar enfermo (vómitos)

  • Pain in your tummy (abdomen).

  • Any yellowing of your skin or the whites of your eyes (jaundice).

  • Itchy skin or unexplained bruising.

  • Pérdida de apetito.

  • Any unexplained flu-like symptoms.

  • Feeling unusually tired or generally unwell.

Si experimenta cualquier otro síntoma que crea que puede deberse a los comprimidos, hable con su médico o farmacéutico para que le aconsejen.

How to store agomelatine

  • Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

If you buy any medicines, check with a pharmacist that they are safe to take with your prescribed medicines.

No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda inmediatamente al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.

Si va a someterse a una operación o a un tratamiento dental, comunique a la persona que lleve a cabo el tratamiento qué medicamentos está tomando.

Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.

No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.

Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.

Informar de los efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.

Lecturas complementarias y referencias

Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • Fecha prevista para la próxima revisión: 14 abr 2028
  • 14 Abr 2025 | Última versión

    Última actualización

    Michael Stewart, MRPharmS

    Revisado por expertos

    Sid Dajani
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