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Valproato sódico para la epilepsia

Epilim, Episenta

Clinical Author's Note (Michael Stewart) 03/04/2018: valproate medicines must not be taken during pregnancy unless there is no suitable alternative. MHRA and the European Medicines Agency have announced strengthened measures to further reduce the risk of exposure to valproate drugs during pregnancy. Any woman or girl of child-bearing potential who needs a valproate medicine must be enrolled on a pregnancy prevention programme. This will involve counselling on potential risks as well as ongoing pregnancy testing during treatment. Click on the link above for more information and speak with your doctor if you have any concerns.

Read the information leaflet from inside your pack.

Take sodium valproate regularly every day. Do not suddenly stop taking it as this can cause your symptoms to return.

If you develop tummy (abdominal) pain, sickness, yellowing of your skin or of the whites of your eyes (jaundice) or any unexplained bruising or bleeding, tell your doctor straightaway.

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About sodium valproate

Tipo de medicamento

Un medicamento antiepiléptico

Utilizado para

Epilepsia

También llamado

Dyzantil®; Epilim®; Episenta®; Epival®; Convulex® (as valproic acid)

Disponible como

Tablets, crushable tablets, oral liquid medicine, modified-release tablets, modified-release capsules, and sachets

Sodium valproate is prescribed to treat epileptic disease and seizures. It can be taken both by adults and by children.

A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. Sodium valproate works by reducing these abnormal electrical activities.

There is also a medicine with a similar name but which is used to treat a different condition. See the medicine leaflet called Valproate semisodium for bipolar disorder for more information about this.

Before taking sodium valproate

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sodium valproate it is important that your doctor knows:

  • Si está embarazada, esperando un bebé o en período de lactancia.

  • Si usted o un miembro cercano de su familia tiene problemas hepáticos.

  • Si tiene algún problema con el funcionamiento de sus riñones.

  • If you have an inflammatory condition called systemic lupus erythematosus (also called lupus or SLE).

  • Si padece un raro trastorno sanguíneo hereditario llamado porfiria.

  • If you have been told you have a mitochondrial disorder or a urea cycle disorder.

  • Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.

  • Si alguna vez ha tenido una reacción alérgica a un medicamento.

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How to take sodium valproate

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about sodium valproate and it will provide you with a full list of the side-effects which you may experience from taking it.

  • Take sodium valproate exactly as your doctor tells you to. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. Most people take one or two doses daily. Doses for children are tailored to their age and weight.

  • Read the printed information with your supply for more details about how you should take your doses. For example, many brands of sodium valproate must be taken with or just after food. Some brands of tablets are crushable to make them easier to swallow. Others must be swallowed whole without crushing or chewing. The label on the pack and the printed information leaflet from inside will provide this sort of information for you. Alternatively, you can ask your pharmacist to advise you.

  • If you have been prescribed sachets (granules), you can swallow the granules by pouring them into your mouth and swallowing them with a drink of water. If you prefer, you can sprinkle the granules on to some soft food (yoghurt or ice cream, for example) or into a cool drink. Do not chew the granules.

  • Try to get into a habit of taking sodium valproate at the same time(s) each day. This will help you avoid missing doses.

  • Si olvida tomar una dosis, tómela en cuanto se acuerde, a menos que sea casi la hora de la siguiente, en cuyo caso omita la dosis olvidada. No tome dos dosis juntas para compensar la dosis olvidada.

Aproveche al máximo su tratamiento

  • Cuando empiece un nuevo tratamiento para la epilepsia puede haber un cambio en el número o tipo de crisis que experimente. Su médico le informará al respecto.

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have blood tests before you start the medicine and while you are taking it.

  • There are several brands of sodium valproate available and your treatment could be affected by switching between brands made by different manufacturers. Each time you collect a new supply from your pharmacy, check to see if it looks the same as you have had before. If it is different, please discuss this with your pharmacist who will advise you.

  • You need to take sodium valproate every day. Stopping treatment suddenly can cause problems. If it becomes necessary for the treatment to stop, your doctor will want you to reduce your dose over a few days.

  • Sodium valproate can harm an unborn child so you must avoid getting pregnant while you are taking sodium valproate. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you are a woman and want to have a family, discuss this with your doctor so that you can be given advice from a specialist about alternative treatment before you become pregnant.

  • Las personas con epilepsia deben dejar de conducir. Su médico le indicará cuándo puede volver a conducir. Normalmente será después de un año sin crisis.

  • Durante el tratamiento de la epilepsia existe un pequeño riesgo de que se produzcan cambios de humor, pensamientos angustiosos y sentimientos suicidas. Si esto ocurre, debe comunicárselo inmediatamente a su médico.

  • If you buy any medicines, always check with a pharmacist that they are suitable to take with your other medicines. Medicines which contain aspirin (such as some cold or flu remedies and painkillers) can interfere with sodium valproate.

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Can sodium valproate cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with sodium valproate. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Muy común

sodium valproate side-effects (these affect more than 1 in 10 people)

¿Qué puedo hacer si me ocurre esto?

Sensación de malestar (náuseas), dolor de estómago

Coma alimentos sencillos: evite las comidas ricas o picantes.

Sensación de temblor

En caso de molestias, hable con su médico

Común

sodium valproate side-effects (these affect fewer than 1 in 10 people)

¿Qué puedo hacer si me ocurre esto?

Caída del cabello

Suele ser temporal y el pelo vuelve a crecer (aunque puede estar más rizado que antes).

Dolor de cabeza

Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza persisten, informe a su médico.

Diarrea

Beber mucha agua para reponer los líquidos perdidos

Sensación de sueño

No conduzca ni utilice herramientas o máquinas. No beba alcohol

Aumento de peso

Intenta seguir una dieta equilibrada y hacer ejercicio con regularidad.

Uncontrolled muscle movements, lack of concentration, allergic reactions, problems with hearing

Informe a su médico de cualquiera de estos síntomas

Problemas en el hígado, cambios en los resultados de algunos análisis de sangre

Su médico comprobará rutinariamente

Important: sodium valproate has been associated with a number of serious unwanted effects affecting the blood, pancreas and liver. Although these occur less commonly than some of the side-effects listed above, you must let your doctor know straightaway if you notice any of the following:

  • Tos o dolor de garganta inexplicables, o cualquier hemorragia o hematoma inusual.

  • Extreme tiredness, tummy (abdominal) pain, sickness (nausea and vomiting), dark urine or yellowing of your skin or of the whites of your eyes (jaundice).

How to store sodium valproate

  • Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.

Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.

Si va a someterse a una operación o a un tratamiento dental, comunique a la persona que lleve a cabo el tratamiento qué medicamentos está tomando.

No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.

Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.

Informar de los efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.

Lecturas complementarias y referencias

Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • Fecha de la próxima revisión: 4 de octubre de 2026
  • 5 Oct 2023 | Última versión

    Última actualización

    Michael Stewart, MRPharmS

    Revisado por expertos

    Sid Dajani
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