Valproato de sodio para la epilepsia
Epilim, Episenta
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 5 Oct 2023
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Nota del Autor Clínico (Michael Stewart) 03/04/2018: valproate medicines must not be taken during pregnancy unless there is no suitable alternative. MHRA and the European Medicines Agency have announced strengthened measures to further reduce the risk of exposure to valproate drugs during pregnancy. Any woman or girl of child-bearing potential who needs a valproate medicine must be enrolled on a programa de prevención del embarazo. Esto implicará asesoramiento sobre los riesgos potenciales, así como pruebas de embarazo continuas durante el tratamiento. Haga clic en el enlace de arriba para obtener más información y hable con su médico si tiene alguna inquietud.
Read the information leaflet from inside your pack.
Take sodium valproate regularly every day. Do not suddenly stop taking it as this can cause your symptoms to return.
If you develop tummy (abdominal) pain, sickness, yellowing of your skin or of the whites of your eyes (jaundice) or any unexplained bruising or bleeding, tell your doctor straightaway.
About sodium valproate
Tipo de medicamento | Un medicamento antiepiléptico |
Usado para | Epilepsia |
También llamado | Dyzantil®; Epilim®; Episenta®; Epival®; Convulex® (as valproic acid) |
Disponible como | Tablets, crushable tablets, oral liquid medicine, modified-release tablets, modified-release capsules, and sachets |
Sodium valproate is prescribed to treat epileptic disease and seizures. It can be taken both by adults and by children.
A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. Sodium valproate works by reducing these abnormal electrical activities.
There is also a medicine with a similar name but which is used to treat a different condition. See the medicine leaflet called Valproato semisódico para el trastorno bipolar para obtener más información sobre esto.
Before taking sodium valproate
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sodium valproate it is important that your doctor knows:
Si estás embarazada, intentando tener un bebé o amamantando.
Si usted o un miembro cercano de su familia tienen problemas hepáticos.
Si tienes algún problema con el funcionamiento de tus riñones.
If you have an inflammatory condition called systemic lupus erythematosus (also called lupus or SLE).
Si tienes un trastorno sanguíneo hereditario raro llamado porfiria.
If you have been told you have a mitochondrial disorder or a urea cycle disorder.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take sodium valproate
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about sodium valproate and it will provide you with a full list of the side-effects which you may experience from taking it.
Take sodium valproate exactly as your doctor tells you to. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. Most people take one or two doses daily. Doses for children are tailored to their age and weight.
Read the printed information with your supply for more details about how you should take your doses. For example, many brands of sodium valproate must be taken with or just after food. Some brands of tablets are crushable to make them easier to swallow. Others must be swallowed whole without crushing or chewing. The label on the pack and the printed information leaflet from inside will provide this sort of information for you. Alternatively, you can ask your pharmacist to advise you.
If you have been prescribed sachets (granules), you can swallow the granules by pouring them into your mouth and swallowing them with a drink of water. If you prefer, you can sprinkle the granules on to some soft food (yoghurt or ice cream, for example) or into a cool drink. Do not chew the granules.
Try to get into a habit of taking sodium valproate at the same time(s) each day. This will help you avoid missing doses.
If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Cuando comienzas un nuevo tratamiento para la epilepsia, puede haber un cambio en el número o tipo de convulsiones que experimentas. Tu médico te aconsejará al respecto.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have blood tests before you start the medicine and while you are taking it.
There are several brands of sodium valproate available and your treatment could be affected by switching between brands made by different manufacturers. Each time you collect a new supply from your pharmacy, check to see if it looks the same as you have had before. If it is different, please discuss this with your pharmacist who will advise you.
You need to take sodium valproate every day. Stopping treatment suddenly can cause problems. If it becomes necessary for the treatment to stop, your doctor will want you to reduce your dose over a few days.
Sodium valproate can harm an unborn child so you debe avoid getting pregnant while you are taking sodium valproate. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you are a woman and want to have a family, discuss this with your doctor so that you can be given advice from a specialist about alternative treatment antes te quedas embarazada.
Las personas con epilepsia deben dejar de conducir. Su médico le aconsejará sobre cuándo podría ser posible que vuelva a conducir. Esto generalmente será después de un año sin convulsiones.
Mientras estás siendo tratado por epilepsia, existe un pequeño riesgo de que puedas desarrollar cambios de humor, pensamientos angustiantes y sentimientos sobre el suicidio. Si esto ocurre, debes informar a tu médico de inmediato.
If you buy any medicines, always check with a pharmacist that they are suitable to take with your other medicines. Medicines which contain aspirin (such as some cold or flu remedies and painkillers) can interfere with sodium valproate.
Can sodium valproate cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with sodium valproate. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Muy común sodium valproate side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling sick (nausea), stomach pain | Mantente en alimentos simples - evita comidas ricas o picantes |
Sensación de temblor | Si es problemático, hable con su médico |
Común sodium valproate side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Pérdida de cabello | Esto suele ser temporal y el cabello vuelve a crecer (aunque puede ser más rizado que antes) |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Diarrea | Bebe mucha agua para reponer los líquidos perdidos |
Sensación de sueño | No conduzca y no utilice herramientas o máquinas. No consuma alcohol |
Increased weight | Intenta llevar una dieta equilibrada y hacer ejercicio regularmente |
Uncontrolled muscle movements, lack of concentration, allergic reactions, problems with hearing | Informe a su médico sobre cualquiera de estos |
Problemas con su hígado, cambios en algunos resultados de análisis de sangre | Su médico revisará rutinariamente estos |
Importante: sodium valproate has been associated with a number of serious unwanted effects affecting the blood, pancreas and liver. Although these occur less commonly than some of the side-effects listed above, you must let your doctor know de inmediato if you notice any of the following:
Una tos o dolor de garganta inexplicables, o cualquier sangrado o moretón inusual.
Extreme tiredness, tummy (abdominal) pain, sickness (nausea and vomiting), dark urine or yellowing of your skin or of the whites of your eyes (jaundice).
How to store sodium valproate
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, donde se encargarán de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.
Preguntas frecuentes
What is the difference between sodium valproate and Valproate semisodium?
Sodium valproate is prescribed to treat epileptic disease and seizures. Valproate semisodium is a similar-sounding medicine used for a different condition, specifically bipolar disorder.
What should I do if my doctor changes the brand of sodium valproate I am taking?
There are several brands of sodium valproate available. Your treatment could be affected by switching between brands made by different manufacturers. Each time you collect a new supply from your pharmacy, check to see if it looks the same as you have had before. If it is different, discuss this with your pharmacist, who will advise you.
If I am feeling sleepy while taking sodium valproate, can I still drive or use machinery?
No, if you are feeling sleepy as a side-effect of sodium valproate, you should not drive or use tools or machines. You should also avoid drinking alcohol.
What should I do if I experience unusual bleeding, bruising, or severe tiredness while taking sodium valproate?
Sodium valproate has been associated with some serious unwanted effects affecting the blood, pancreas, and liver. If you notice an unexplained cough or sore throat, or any unusual bleeding or bruising, extreme tiredness, tummy pain, sickness, dark urine, or yellowing of your skin or eyes, you must tell your doctor straightaway.
Can I take aspirin-containing medicines for pain relief while on sodium valproate?
No, medicines which contain aspirin, such as some cold or flu remedies and painkillers, can interfere with sodium valproate. Always check with a pharmacist if any over-the-counter medicine is suitable to take with your prescribed medication.
Lecturas adicionales y referencias
- Manufacturer's PIL, Epilim® 200 mg and 500 mg gastro-resistant tablets; Sanofi, El Compendio Electrónico de Medicamentos. Fecha enero de 2022.
- Medicamentos Completo BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
- Manufacturer's PIL, Epilim® Chrono 200 mg, 300 mg, 500 mg CR Tablets; Sanofi, The electronic Medicines Compendium. Dated January 2022
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
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