Can I take Oxypro and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can significantly increase the risk of serious side effects. You may feel extremely drowsy, dizzy, or confused. Most importantly, this combination can slow down or stop your breathing (respiratory depression), which can be life-threatening. It can also lead to a deep sleep from which you cannot be woken (coma).
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Why this happens
Both Oxypro (oxycodone) and pregabalin act as depressants on the central nervous system. When taken together, their effects 'stack' or add up. Oxycodone is an opioid painkiller that slows down the brain's control of breathing, and pregabalin enhances this effect, making it much more dangerous than taking either medicine alone.
What you should do
You must only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. Your doctor should start you on the lowest possible doses and monitor you closely.
Seek emergency medical help immediately if you or someone taking these medicines experiences:
Very slow or shallow breathing
Extreme sleepiness or inability to stay awake
Limp muscles or cold, clammy skin
Pinpoint pupils
A slow heartbeat or fainting
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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