Can I take Oxypro and Paracetamol together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no harmful interaction between these two medications. In fact, they are frequently prescribed together to provide better pain relief than either drug could achieve on its own. However, you must be extremely careful to check the ingredients of your 'Oxypro' (Oxycodone) tablets, as some brands of oxycodone come already mixed with paracetamol in a single pill.
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Why this happens
Oxypro (oxycodone) is an opioid painkiller that works on the central nervous system, while paracetamol works differently to reduce pain signals and fever. Because they work through different pathways, they can be used at the same time (additive effect) to manage more severe pain.
What you should do
It is safe to take these together as long as you do not exceed the maximum daily dose of paracetamol (usually 4000mg or eight 500mg tablets in 24 hours). Always check your Oxypro packaging; if it is a combination product that already contains paracetamol, do not take extra paracetamol. If you have liver or kidney problems, consult your doctor before combining these medicines.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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