Can I take Esomeprazole and Trazodone together?
Drug interaction guide
Originally published 25 Jan 2026
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Esomeprazole may reduce the amount of trazodone that your body absorbs. This could potentially make trazodone less effective at treating your symptoms (such as depression or sleep issues). Additionally, both medications can rarely affect the electrical activity of your heart, though this risk is generally low.
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Why this happens
Esomeprazole reduces stomach acid. Trazodone needs an acidic environment to dissolve properly so it can be absorbed into the bloodstream. Lower acid levels mean less medicine gets into your system. There is also a theoretical risk of 'QT prolongation' (a change in heart rhythm) when these types of drugs are used together.
What you should do
You can generally take these together, but monitor your mood or sleep patterns closely. If you feel your trazodone is not working as well as it used to, or if you experience any unusual heart palpitations or dizziness, speak with your doctor. They may need to adjust your dose or the timing of when you take your tablets.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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