Can I take Oestrogel pump-pack /actuation and Vitamin c together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking high doses of Vitamin C (ascorbic acid) alongside Oestrogel can increase the levels of oestrogen in your bloodstream. This might increase the risk of oestrogen-related side effects, such as breast tenderness, bloating, or nausea. Conversely, if you suddenly stop taking Vitamin C after your body has adjusted to the combination, your oestrogen levels could drop, potentially causing a return of menopause symptoms.
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Why this happens
Both Vitamin C and oestrogen (estradiol) compete for the same 'breakdown' process in the body (specifically a process called sulfation). Because the Vitamin C keeps the breakdown enzymes busy, less oestrogen is cleared from your system, leading to higher levels in the blood.
What you should do
You do not need to avoid Vitamin C, but you should avoid taking very high doses (over 1,000mg per day) of Vitamin C supplements. If you are already taking a Vitamin C supplement, try to be consistent with your daily dose rather than starting and stopping it abruptly. If you notice increased breast pain or other side effects, speak to your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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