Can I take Levothyroxine 25 and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking sertraline while on levothyroxine may make your thyroid medication less effective. This could lead to symptoms of an underactive thyroid, such as feeling tired, cold, or gaining weight.
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Why this happens
Sertraline can change how your body processes levothyroxine. It may reduce the amount of thyroid hormone available in your blood, meaning your current dose of levothyroxine might not be enough to keep your thyroid levels stable.
What you should do
You should inform your doctor that you are taking both medications. They may want to perform a blood test to check your thyroid-stimulating hormone (TSH) levels. Do not change your dose of either medicine without medical advice. If you notice symptoms of an underactive thyroid returning, contact your GP.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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