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Can I take Hydrochlorothiazide and Lisinopril together?

Guía de interacción de medicamentos

Taking these two medicines together can cause your blood pressure to drop lower than intended, especially when you first start the combination or increase your dose. This might make you feel dizzy, lightheaded, or faint. There is also a risk that your kidney function could be affected or that your potassium levels could rise too high.

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Por qué sucede esto

Both medicines work to lower blood pressure but in different ways. Hydrochlorothiazide is a 'water tablet' (diuretic) that removes salt and water from the body, while lisinopril (an ACE inhibitor) relaxes blood vessels. When used together, their effects add up. Additionally, lisinopril can cause the body to hold onto potassium, while hydrochlorothiazide usually causes you to lose it; however, the combined effect on the kidneys can sometimes lead to an imbalance.

You should take this combination only under your doctor's supervision. To prevent dizziness, try getting up slowly from a sitting or lying position. Your doctor will likely perform regular blood tests to check your kidney function and potassium levels. If you feel very dizzy, faint, or develop a persistent dry cough, contact your GP.

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Embarazo

Do not use if you are pregnant or planning to become pregnant. This medicine can cause serious injury or death to an unborn baby, particularly if taken during the second and third trimesters.

Angioedema (Severe Swelling)

Seek immediate medical help if you experience swelling of the face, lips, tongue, or throat, or difficulty breathing. This is a rare but life-threatening allergic reaction more common with ACE inhibitors like lisinopril.

Skin Cancer Risk

This medicine can make your skin more sensitive to sunlight. Long-term use is linked to an increased risk of non-melanoma skin cancer. You must protect your skin from the sun and check for any new or changing moles or lesions.

Alcohol

Drinking alcohol while taking these medicines can cause your blood pressure to drop too low. This may make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to limit alcohol intake, particularly when you first start these medicines or when your dose is increased.

Sustitutos de la sal (a base de potasio)

Lisinopril can increase the levels of potassium in your blood. Many salt substitutes (such as Lo-Salt) contain potassium instead of sodium. Using these while taking lisinopril can lead to dangerously high potassium levels (hyperkalaemia). Check with your pharmacist before using salt substitutes.

High-potassium foods

Because lisinopril can raise potassium levels, you should avoid eating very large amounts of foods high in potassium (such as bananas, spinach, or sweet potatoes) on a regular basis. Normal dietary amounts are usually fine, but consult your doctor before making significant dietary changes.

Liquorice (Natural/Black)

Eating large amounts of natural black liquorice can cause your body to lose potassium and retain sodium, which can counteract the effects of your blood pressure medication and increase the risk of side effects.

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Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 14 Mar 2026 | Publicado originalmente
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