Can I take Atorvastatin and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between atorvastatin and Rybelsus (semaglutide). Both medications are often prescribed together to manage cardiovascular risk and blood sugar levels in patients with type 2 diabetes.
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Why this happens
Atorvastatin is a statin used to lower cholesterol, primarily processed by the liver (CYP3A4 enzyme). Rybelsus is a GLP-1 receptor agonist used for blood sugar control. While Rybelsus slows down how quickly the stomach empties, it has not been shown to significantly change how the body absorbs or processes atorvastatin.
What you should do
You can safely take these medications together as prescribed by your doctor. However, because Rybelsus can cause nausea or vomiting when you first start it, monitor yourself for any unusual muscle pain or weakness (a rare side effect of atorvastatin), as dehydration from vomiting can sometimes increase the risk of muscle issues. Always follow the specific dosing instructions for Rybelsus, which must be taken on an empty stomach with a small sip of plain water.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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