Can I take Pyridostigmine and Ramipril together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together may increase the risk of a rare but serious allergic-type reaction called angioedema (swelling under the skin). It may also cause your blood pressure to drop lower than intended, potentially making you feel dizzy or faint.
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Why this happens
Both drugs can affect a system in the body that regulates swelling and blood pressure. Ramipril (an ACE inhibitor) prevents the breakdown of a substance called bradykinin. Pyridostigmine can also influence this pathway, and when combined, the levels of bradykinin may rise too high, leading to swelling. Additionally, both drugs can lower blood pressure through different pathways, leading to an additive effect.
What you should do
You can usually take these together, but you must be aware of the signs of an allergic reaction. Seek immediate medical help if you experience swelling of the face, lips, tongue, or throat, or if you have difficulty breathing. If you feel very dizzy when standing up, speak to your doctor as your blood pressure may need monitoring.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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