Can I take Codeine and Ibuprofen together?

Why this happens

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation at the site of injury. Codeine is an opioid that works in the brain and spinal cord to change how your body feels and responds to pain. Because they target pain through different pathways, their effects are additive.

What you should do

It is safe to take these together, provided you do not exceed the recommended dose for either medication. Be aware that many "plus" or "extra" branded painkillers already contain both ingredients (such as Nurofen Plus), so always check the packaging to avoid accidentally taking a double dose. Common side effects when taking both may include constipation or an upset stomach.

Important precautions

Asthma

Do not take codeine or ibuprofen if you have asthma, as they can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Addiction and Dependency

Codeine contains an opioid which can cause addiction if used for more than 3 days. Long-term use can lead to withdrawal symptoms when you stop.

Breastfeeding

Do not take codeine while breastfeeding. It passes into breast milk and can cause life-threatening breathing problems or extreme sleepiness in your baby.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Stomach Ulcers or Bleeding

Avoid ibuprofen if you have ever had a stomach ulcer or gastrointestinal bleeding, as it can cause serious internal bleeding or perforation.

Food and drink warnings

Alcohol

You must avoid drinking alcohol while taking codeine. Both alcohol and codeine are central nervous system depressants. Combining them significantly increases the risk of severe drowsiness, dizziness, and dangerous breathing problems (respiratory depression).

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

Food (General)

You should ideally take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduces the chance of indigestion or stomach upset.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.