Can I take Apixaban and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between apixaban and Rybelsus (semaglutide). These two medicines work in different ways and do not typically interfere with how the other is absorbed, broken down, or removed from the body.
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Why this happens
Apixaban is an anticoagulant (blood thinner) that works by blocking a clotting factor called Factor Xa. Rybelsus is a GLP-1 receptor agonist used for type 2 diabetes that mimics a natural hormone to lower blood sugar. They are processed by different pathways in the liver and kidneys, and they do not share the same targets in the body.
What you should do
You can safely take these two medicines together as prescribed by your doctor. However, because Rybelsus can cause nausea or vomiting when you first start taking it, be mindful that severe vomiting could potentially affect how much apixaban your body absorbs. If you experience persistent vomiting, contact your doctor for advice. Always follow the specific dosing instructions for Rybelsus (taking it on an empty stomach with a small sip of water) to ensure it works correctly.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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