Can I take Amitriptyline and Aspirin together?
Drug interaction guide
Originally published 25 Jan 2026
Satisface las necesidades del paciente directrices editoriales
- DescargarDescargar
- Compartir
- Idioma
- Debate
Taking amitriptyline and aspirin together can increase your risk of bleeding, particularly in the stomach or gut. You may also find that you bruise more easily.
En este artículo:
Seguir leyendo
Why this happens
Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. Aspirin is a blood-thinner that also stops platelets from sticking together. When used together, their combined effect makes it harder for your blood to clot, increasing the risk of internal bleeding.
What you should do
Back to contentsUse this combination with caution. If you need to take them together, watch for signs of bleeding such as dark, tarry stools, coughing up blood, or severe stomach pain. If you notice these symptoms, contact your doctor immediately. Your doctor may suggest a different painkiller or a medicine to protect your stomach.
Seguir leyendo
Important precautions
Back to contentsAsma
Do not take aspirin if you have asthma, as it can trigger a severe or life-threatening asthma attack.
Pregnancy (third trimester)
Do not take aspirin if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.
Pensamientos suicidas
Amitriptyline can increase thoughts of self-harm or suicide, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel distressed.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.
Seguir leyendo
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Tratamiento y medicación
Can I take Ashwagandha and Vitamin D together?
There are no known negative interactions between ashwagandha and vitamin D. In fact, they are often taken together as part of a wellness routine.
Tratamiento y medicación
Can I take Aspirin and Doxazosin together?
Taking aspirin and doxazosin together may slightly reduce the blood-pressure-lowering effect of doxazosin. Additionally, both medications can increase the risk of stomach irritation or bleeding, especially if taken in high doses or over a long period.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
Pregunte, comparta, conecte.
Explore debates, formule preguntas y comparta experiencias sobre cientos de temas de salud.
¿Se encuentra mal?
Evalúe sus síntomas en línea de forma gratuita
Suscríbase al boletín informativo para pacientes.
Tu dosis semanal de consejos de salud claros y fiables, redactados para ayudarte a sentirte informado, seguro y en control.
Al suscribirte, aceptas nuestra Política de privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.