Can I take Codeine and Omeprazole together?

Why this happens

Codeine needs to be converted into morphine by a specific enzyme in the liver (called CYP2D6) to provide pain relief. Omeprazole can slightly interfere with this process, meaning less codeine is turned into the active pain-killing form. Additionally, omeprazole reduces stomach acid, which can sometimes change how quickly codeine tablets dissolve and enter your system.

It is generally safe to take these two medicines together. However, if you feel that your pain relief is not working as well as it should, speak to your doctor or pharmacist. They may suggest a different type of painkiller or a different medicine for your stomach acid.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.