Can I take Atenolol and Rybelsus (semaglutide) together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking Rybelsus (semaglutide) alongside atenolol may increase the risk of your blood sugar levels dropping too low (hypoglycaemia). Additionally, atenolol can 'mask' or hide the common warning signs of low blood sugar, such as a fast heartbeat or palpitations.
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Why this happens
Rybelsus lowers blood sugar. While atenolol is for blood pressure, it can also lower blood sugar or make it harder for your body to recover from a 'sugar crash'. Crucially, atenolol blocks the 'fight or flight' response (adrenaline) that usually causes your heart to race when your sugar is low, meaning you might not realise you are in danger until the symptoms are severe.
What you should do
Back to contentsYou can take these together, but you must be extra vigilant. Monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise other signs of low blood sugar that atenolol doesn't hide, such as sweating, dizziness, hunger, or confusion. If you feel unwell, treat the low sugar immediately and inform your GP.
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Important precautions
Back to contentsAsthma or COPD
Atenolol can cause severe breathing difficulties or trigger a life-threatening asthma attack by narrowing your airways. Do not take this medicine if you have a history of asthma or wheezing.
History of pancreatitis or severe stomach pain
Rybelsus can cause inflammation of the pancreas (pancreatitis). Seek immediate medical help if you experience severe, persistent stomach pain that may radiate to your back.
Diabetes
Atenolol can mask the warning signs of low blood sugar (hypoglycaemia), such as a fast heartbeat or tremors. You must monitor your blood sugar more closely as you may not feel the usual symptoms of a 'hypo'.
Food and drink warnings
Back to contentsFood, beverages, and other oral medicines
Rybelsus must be taken on an empty stomach with no more than half a glass (120ml) of plain water. You must wait at least 30 minutes before eating, drinking anything else, or taking other oral medicines. If you do not wait, the medicine will not be absorbed properly and will not work.
Alcohol
Alcohol can affect blood sugar levels and may increase the risk of low blood sugar (hypoglycaemia) when taking Rybelsus. For Atenolol, alcohol can enhance the blood-pressure-lowering effect, which may make you feel dizzy or lightheaded.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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