Can I take Aspirin 300 and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking aspirin and sertraline together increases your risk of bleeding, particularly in the stomach or gut. You may bruise more easily or notice that small cuts take longer to stop bleeding. In more serious cases, it can lead to internal bleeding, which might show up as very dark or 'tar-like' stools, or vomiting blood.
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Why this happens
Sertraline belongs to a group of antidepressants (SSRIs) that can lower the amount of serotonin in your blood platelets, which are the cells responsible for clotting. Aspirin also thins the blood by preventing these platelets from sticking together. When used together, their effects combine, making it much harder for your blood to clot if a blood vessel is damaged.
What you should do
You should only take these two medicines together if your doctor has specifically told you to. If you must take both, watch out for signs of bleeding such as unusual bruising, nosebleeds, or dark stools. If you experience severe stomach pain or vomit blood (which may look like coffee grounds), seek medical help immediately. Your doctor may suggest taking a 'stomach protector' medicine (like omeprazole) to reduce the risk of ulcers.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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