Can I take Amlodopine and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking Rybelsus (semaglutide) alongside amlodipine may occasionally lead to a further drop in blood pressure. While Rybelsus is primarily for blood sugar, it can sometimes cause a slight reduction in blood pressure or a small increase in heart rate. When combined with a blood pressure medicine like amlodipine, you might feel slightly more dizzy or lightheaded, especially when standing up quickly.
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Why this happens
Amlodipine works by relaxing blood vessels to lower blood pressure. Rybelsus (a GLP-1 receptor agonist) can have mild effects on the cardiovascular system, including lowering blood pressure and increasing heart rate. Together, these effects can be additive, meaning they might lower your blood pressure more than either drug would on its own.
What you should do
You can take these medicines together, but you should monitor your blood pressure regularly at home. If you feel dizzy, lightheaded, or faint, sit or lie down until the feeling passes. Mention these symptoms to your doctor, as they may wish to adjust your amlodipine dose. Always stay well-hydrated, as Rybelsus can sometimes cause nausea or vomiting which can lead to dehydration and further lower your blood pressure.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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