Can I take 100 and Palexia together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking alcohol with Palexia (tapentadol) can lead to dangerous levels of sleepiness, breathing difficulties, and a high risk of accidental overdose. Alcohol can also cause the medicine to be released into your bloodstream too quickly (known as 'dose dumping'), which can be fatal.
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Why this happens
Both alcohol and Palexia are central nervous system depressants. When used together, they 'stack' their effects on the brain, significantly slowing down heart rate and breathing. Alcohol can also interfere with the way the tablet is designed to release the medicine, causing a sudden, dangerous spike in drug levels.
What you should do
Back to contentsDo not drink any alcohol while you are taking Palexia. This includes beer, wine, and spirits. If you have accidentally consumed alcohol while on this medication, seek medical advice immediately. If you experience extreme drowsiness or difficulty breathing, call 999.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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