Can I take Loratadine and Ibuprofen together?
Drug interaction guide
Originally published 24 Jan 2026
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There are no known significant interactions between loratadine and ibuprofen. It is generally considered safe to take these two medicines together.
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Why this happens
Loratadine is an antihistamine used for allergies, and ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation. They work in different ways in the body and are processed by different pathways in the liver and kidneys, meaning they do not interfere with each other's effectiveness or safety.
What you should do
You can take these medicines together if needed. Always follow the dosage instructions on the packaging for each product. If you have underlying health conditions, such as stomach ulcers, kidney problems, or asthma, check with a pharmacist before taking ibuprofen.
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Important precautions
Asma
Do not take this medicine if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a severe, life-threatening asthma attack.
Stomach ulcers or bleeding
Avoid this medicine if you have a history of stomach ulcers, perforation, or bleeding, as it significantly increases the risk of serious gastrointestinal damage.
Pregnancy (third trimester)
Do not take ibuprofen if you are more than 28 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.
Food and drink warnings
Alcohol
Drinking alcohol while taking ibuprofen can increase the risk of stomach irritation and serious side effects like stomach bleeding or ulcers. It is best to limit or avoid alcohol while taking this medicine.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
24 Enero 2026 | Publicado originalmente

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