Can I take Lions mane and Shiitake together?
Drug interaction guide
Originally published 24 Jan 2026
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There are no known harmful interactions between Lion's Mane (Hericium erinaceus) and Shiitake (Lentinula edodes) mushrooms. Both are commonly consumed together as food or supplements.
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Why this happens
Both mushrooms contain bioactive compounds like beta-glucans that support the immune system. They do not interfere with each other's absorption or breakdown in the body. Instead, they may have a complementary effect on general health.
What you should do
It is generally safe to take these together. However, if you are taking blood-thinning medication (like warfarin) or diabetes medication, speak to your doctor first, as both mushrooms may have mild effects on blood clotting and blood sugar levels.
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Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
24 Enero 2026 | Publicado originalmente
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