Can I take Fluoxetine and Tramadol together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking these two medicines together can lead to a rare but very serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle stiffness, or diarrhoea. In extreme cases, it can cause seizures. Additionally, fluoxetine can make tramadol less effective at relieving your pain.
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Why this happens
Both fluoxetine and tramadol increase the levels of serotonin in the brain. When used together, these effects add up and can reach dangerous levels. Furthermore, fluoxetine blocks a specific enzyme in the liver (CYP2D6) that is responsible for converting tramadol into its active, pain-killing form. This means the tramadol may not work as well for your pain, while the risk of side effects actually increases.
What you should do
You should speak to your doctor before taking these two medicines together. They may prefer to prescribe an alternative painkiller that does not interact with your antidepressant. If your doctor decides you must take both, they will monitor you closely. Seek urgent medical help if you experience extreme confusion, shivering, very high fever, or muscle twitching.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
24 Enero 2026 | Publicado originalmente
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