Can I take Atorvastatin and Reisha together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking Reishi mushroom alongside atorvastatin may increase the risk of side effects, particularly those affecting the liver or muscles. Reishi may also have a mild blood-thinning effect, which could theoretically increase the risk of bruising or bleeding when combined with certain medications, though the primary concern here is the potential strain on the liver.
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Why this happens
Both atorvastatin and Reishi mushroom are processed by the liver. Reishi contains compounds that may interfere with the liver enzymes (specifically CYP450 enzymes) responsible for breaking down atorvastatin. If the liver cannot clear the medication effectively, levels of atorvastatin in the blood may rise, increasing the risk of toxicity. Additionally, both substances can individually affect liver function, potentially leading to an additive effect on liver enzymes.
What you should do
You should consult your doctor or pharmacist before combining Reishi mushroom with atorvastatin. If you decide to take both, be alert for signs of liver issues (such as yellowing of the eyes or skin, dark urine, or upper stomach pain) or unexplained muscle pain, tenderness, or weakness. Your doctor may wish to monitor your liver function more closely through routine blood tests.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
24 Enero 2026 | Publicado originalmente

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