Can I take Allupurinol and Atenolol together?
Drug interaction guide
Originally published 24 Jan 2026
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There is a potential for these two medicines to interact, which may lead to an increased risk of allergic reactions or a slight change in how your kidneys handle the medication. While most people take this combination without issues, there have been rare reports of serious skin rashes or hypersensitivity reactions when taking allopurinol alongside certain blood pressure medications like atenolol.
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Why this happens
Both allopurinol and atenolol are cleared from the body through the kidneys. It is thought that taking them together might slightly alter how the kidneys process the drugs, or trigger an overactive immune response in sensitive individuals.
What you should do
You can usually take these medicines together, but you should be vigilant. Contact your doctor immediately if you develop a skin rash, hives, or any signs of an allergic reaction (such as swelling of the face or difficulty breathing). Your doctor may want to monitor your kidney function with routine blood tests.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
24 Enero 2026 | Publicado originalmente
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